gene

IL13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

94Connections

0Hypotheses

0Analyses

50Outgoing

31Incoming

Summary

Page for IL13 — Interleukin 13

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🧬 Gene Info

Gene Symbol	IL13
Full Name	Interleukin-13
Chromosome	5q31.1.
Function	is a Th2-associated cytokine encoded by the IL13 gene on chromosome 5q31.
Amino Acids	146 aa
Exons	5
Pathways	PI3K, MAPK, NF-κB
UniProt ID	[P08960](https://www.uniprot.org/uniprot/P08960)
Ensembl ID	ENSG00000169194
OMIM	147683
GeneCards	IL13
Human Protein Atlas	IL13
IL-13v1	Full-length isoform (146 aa)
IL-13v2	Truncated form with altered C-terminus
IL-13ΔE4	Exon 4 deletion variant
Associated Diseases	Atopic Dermatitis, Mitochondrial Dysfunction
Known Drugs/Compounds	Tralokinumab
Interactions	CHRNE, WNT11, GRIN3B, TNFRSF1B, TNFRSF13C, HCRTR1
KG Connections	94 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IL13["IL13"]
    CLDN1["CLDN1"]
    CLDN4["CLDN4"]
    OCLN["OCLN"]
    Als["Als"]
    Atherosclerosis["Atherosclerosis"]
    CHRNE["CHRNE"]
    WNT11["WNT11"]
    GRIN3B["GRIN3B"]
    TNFRSF1B["TNFRSF1B"]
    GABA["GABA"]
    TNFRSF13C["TNFRSF13C"]
    HCRTR1["HCRTR1"]
    CYTOKINES["CYTOKINES"]
    Wnt["Wnt"]
    Microglia["Microglia"]
    Astrocyte["Astrocyte"]
    APOE["APOE"]
    FGF2["FGF2"]
    CASP1["CASP1"]
    RAS["RAS"]
    IL13 -.->|"inhibits"| CLDN1
    IL13 -.->|"inhibits"| CLDN4
    IL13 -.->|"inhibits"| OCLN
    IL13 -->|"activates"| Als
    IL13 -->|"expressed in"| Atherosclerosis
    IL13 -->|"activates"| CHRNE
    IL13 -->|"activates"| WNT11
    IL13 -->|"activates"| GRIN3B
    IL13 -->|"activates"| TNFRSF1B
    IL13 -->|"activates"| GABA
    IL13 -->|"activates"| TNFRSF13C
    IL13 -->|"activates"| HCRTR1
    IL13 -->|"activates"| CYTOKINES
    IL13 -->|"activates"| Wnt
    IL13 -->|"activates"| Microglia
    IL13 -->|"activates"| Astrocyte
    IL13 -.-|"associated"| APOE
    IL13 -.-|"associated"| FGF2
    IL13 -.-|"associated"| CASP1
    IL13 -->|"expressed in"| RAS
    style IL13 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (63)

Target	Relation	Type	Str
Atopic Dermatitis	causes	disease	0.95
Type 2 Inflammation	mediates	process	0.93
Systemic Inflammation	contributes_to	process	0.90
systemic inflammation	upregulates	process	0.85
macrophage	activates	cell_type	0.80
Mitochondrial Dysfunction	causes	phenotype	0.75
CLDN1	inhibits	gene	0.72
OCLN	inhibits	gene	0.72
CLDN4	inhibits	gene	0.72
Als	activates	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
ALS	activates	disease	0.65
CHRNE	activates	gene	0.60
WNT11	activates	gene	0.60
GRIN3B	activates	gene	0.60
TNFRSF1B	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
HCRTR1	activates	gene	0.60
APOE	associated_with	gene	0.60
FGF2	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
MRC1	associated_with	gene	0.60
HIF1A	associated_with	gene	0.60
PPAR	associated_with	gene	0.60
GRM2	activates	gene	0.60
PI3K	expressed_in	gene	0.60
CHRM4	activates	gene	0.60
MYO7A	activates	gene	0.60
ADRA2B	activates	gene	0.60
CRH	activates	gene	0.60
WNT1	activates	gene	0.60
Rb	activates	protein	0.60
ICAM1	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
IL4	regulates	gene	0.60
TRAF6	regulates	gene	0.60
TNF	activates	gene	0.60
IL6	inhibits	gene	0.60
TNF	inhibits	gene	0.60
neuroinflammation	regulates	disease	0.60
GABA	activates	gene	0.60
CYTOKINES	activates	gene	0.60
Wnt	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
RAS	expressed_in	gene	0.60
IRS1	associated_with	gene	0.60
MIRNAS	expressed_in	gene	0.60
T Cell	expressed_in	cell_type	0.60
AND	activates	gene	0.60

Incoming (31)

Source	Relation	Type	Str
Tralokinumab	inhibits	drug	0.99
CHRM4	activates	gene	0.60
MYO7A	activates	gene	0.60
GRM2	activates	gene	0.60
WNT1	activates	gene	0.60
CRH	activates	gene	0.60
ADRA2B	activates	gene	0.60
ICAM1	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
TNFRSF1B	activates	gene	0.60
GRIN3B	activates	gene	0.60
HCRTR1	activates	gene	0.60
WNT11	activates	gene	0.60
PPAR	associated_with	gene	0.60
AKT	expressed_in	gene	0.60
APOE	associated_with	gene	0.60
MRC1	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
FGF2	associated_with	gene	0.60
IL10	regulates	gene	0.60
CCR2	associated_with	gene	0.60
ASTROCYTE	activates	gene	0.60
WNT	activates	gene	0.60
CYTOKINES	activates	gene	0.60
GENES	associated_with	gene	0.60
MIRNAS	expressed_in	gene	0.60
IRS1	associated_with	gene	0.60
AND	expressed_in	gene	0.60
RAS	expressed_in	gene	0.60
HIF1A	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL13

Understanding Entity Pages

Summary

Wiki Pages (7)

IL13 — Interleukin 13

adra2b Gene

WNT11 Gene

WNT1 Gene

OCLN — Occludin