gene

MYO7A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYO7A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

135Connections

0Hypotheses

0Analyses

50Outgoing

46Incoming

Summary

MYO7A is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in, expressed in. Associated with Aging, Cancer, Cardiovascular. Connected to 72 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MYO7A
Full Name	Myosin VIIa
Chromosome	11q13.5
Function	It moves towards the plus (barbed) end of actin, which allows it to transport cargo from the cell body towards the periphery in epithelial cells and neurons 4.
Primary Expression	stereocilia of hair cells where it participates in the transport of proteins essential for stereocilia structure and function [6](https://pubmed
Molecular Weight	221 kDa
Amino Acids	215 aa
Exons	49
Pathways	Autophagy, Invasion, Mitochondrial Function, Mitophagy, Toll-Like Receptor
UniProt ID	[P12883](https://www.uniprot.org/uniprot/P12883)
Ensembl ID	ENSG00000135624
OMIM	120650
GeneCards	MYO7A
Human Protein Atlas	MYO7A
N-terminal motor domain	Contains the ATPase activity and actin-binding sites responsible for force generation
Associated Diseases	Cancer, Lung Cancer, Tumor, USH1B
Interactions	MAP1LC3B, OPTN, PARKIN, PINK1, XBP1, ATF3
KG Connections	135 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MYO7A["MYO7A"]
    MYO7A -->|"causes"| USH1B["USH1B"]
    MYO7A -->|"activates"| Aging["Aging"]
    MYO7A -->|"activates"| Cardiovascular["Cardiovascular"]
    MYO7A -->|"activates"| Retinitis_Pigmentosa["Retinitis Pigmentosa"]
    MYO7A -->|"activates"| Retinal_Degeneration["Retinal Degeneration"]
    MYO7A -->|"expressed in"| PHOTORECEPTOR_CELLS["PHOTORECEPTOR_CELLS"]
    MYO7A -->|"expressed in"| MULLER_GLIAL_CELLS["MULLER_GLIAL_CELLS"]
    MYO7A -->|"activates"| MAP1LC3B["MAP1LC3B"]
    MYO7A -->|"activates"| OPTN["OPTN"]
    MYO7A -->|"activates"| PARKIN["PARKIN"]
    PTEN["PTEN"] -->|"activates"| MYO7A
    USP30["USP30"] -->|"activates"| MYO7A
    FOXO3["FOXO3"] -->|"activates"| MYO7A
    LC3B["LC3B"] -->|"activates"| MYO7A
    OPTN -->|"activates"| MYO7A
    MAP1LC3B -->|"activates"| MYO7A
    NRL["NRL"] -->|"activates"| MYO7A
    GENES["GENES"] -->|"activates"| MYO7A
    ATF3["ATF3"] -->|"activates"| MYO7A
    XBP1["XBP1"] -->|"activates"| MYO7A

Outgoing (89)

Target	Relation	Type	Str
USH1B	causes	disease	0.72
UBIQUITIN	activates	gene	0.70
mitochondrial functions	dysregulates	process	0.70
proteasomal ubiquitin-dependent protein catabolic processes	dysregulates	process	0.70
Autophagy	activates	pathway	0.70
Retinal Degeneration	activates	disease	0.65
Retinitis	activates	disease	0.65
Aging	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Retinitis Pigmentosa	activates	disease	0.65
Tumor	implicated_in	disease	0.65
Cancer	implicated_in	disease	0.65
Lung Cancer	implicated_in	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
PHOTORECEPTOR_CELLS	expressed_in	cell_type	0.64
MULLER_GLIAL_CELLS	expressed_in	cell_type	0.64
MAP1LC3B	activates	gene	0.60
OPTN	activates	gene	0.60
PARKIN	activates	gene	0.60
PINK1	activates	gene	0.60
XBP1	activates	gene	0.60
ATF3	activates	gene	0.60
TOMM20	activates	gene	0.60
PTEN	activates	gene	0.60
USP30	activates	gene	0.60
FOXO3	activates	gene	0.60
HSPD1	activates	gene	0.60
COX4I1	activates	gene	0.60
GRIA2	activates	gene	0.60
PRKN	activates	gene	0.60
HSP60	activates	gene	0.60
OPTINEURIN	activates	gene	0.60
WIF1	implicated_in	gene	0.60
SFN	implicated_in	gene	0.60
TRAF6	activates	gene	0.60
MMP9	implicated_in	gene	0.60
GRM2	activates	gene	0.60
WNT1	activates	gene	0.60
CRH	activates	gene	0.60
ADRA2B	activates	gene	0.60
IL13	activates	gene	0.60
CHRNE	activates	gene	0.60
WNT11	activates	gene	0.60
GRIN3B	activates	gene	0.60
TNFRSF1B	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
HCRTR1	activates	gene	0.60
CHRM4	activates	gene	0.60
Rb	activates	protein	0.60

Incoming (46)

Source	Relation	Type	Str
AUTOPHAGY	activates	gene	0.70
PTEN	activates	gene	0.60
USP30	activates	gene	0.60
FOXO3	activates	gene	0.60
OPTN	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
ATF3	activates	gene	0.60
XBP1	activates	gene	0.60
HSPD1	activates	gene	0.60
PRKN	activates	gene	0.60
OPTINEURIN	activates	gene	0.60
TOMM20	activates	gene	0.60
HSP60	activates	gene	0.60
PINK1	activates	gene	0.60
PARKIN	activates	gene	0.60
GRIA2	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
BECN1	activates	gene	0.60
TNF	activates	gene	0.60
TLR4	activates	gene	0.60
COX4I1	activates	entity	0.60
CHRM4	activates	gene	0.60
WNT1	activates	gene	0.60
TNFRSF1B	activates	gene	0.60
GRIN3B	activates	gene	0.60
CRH	activates	gene	0.60
HCRTR1	activates	gene	0.60
WNT11	activates	gene	0.60
IL13	activates	gene	0.60
CHRNE	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
GRM2	activates	gene	0.60
ADRA2B	activates	gene	0.60
LC3B	activates	gene	0.60
NRL	activates	gene	0.60
GENES	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
CYTOKINES	activates	gene	0.60
WNT	activates	gene	0.60
RNA SPLICING	activates	gene	0.60
RNA	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
GABA	activates	gene	0.60
MAP1LC3B	co_expressed_with	gene	0.50
LC3B	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MYO7A

Understanding Entity Pages

Summary

Wiki Pages (19)

MYO7A — Myosin VIIa

USH1G — USHER Syndrome 1G Protein (SANS)

USH1C Gene

BAFFR Gene (TNFRSF13C)

GPR98 Gene

WNT11 Gene

Usher Syndrome

WNT1 Gene

Retinitis Pigmentosa

Cochlear Hair Cells in Aging

WHRN Gene

TNFRSF1B Gene

Inner Hair Cells

Outer Hair Cells

USH1G Protein

Cochlear Hair Cells in Auditory Neuropathy Spectrum Disorder

Retinal Organoid Photoreceptors