Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ELAVL4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ELAVL4 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in, associated with. Associated with Als, Dementia, Ms. Connected to 16 entities in the SciDEX knowledge graph.
| Gene Symbol | ELAVL4 |
| Full Name | ELAV Like Neuron-Specific RNA Binding Protein 4 |
| Chromosome | 1p31.3 |
| Function | ELAVL4 encodes ELAV-like protein 4 (also known as HU antigen D), a neuron-specific RNA-binding protein. |
| Primary Expression | neurons of the central and peripheral nervous systems |
| Molecular Weight | 38 kDa |
| Amino Acids | 326 aa |
| Pathways | Apoptosis, Autophagy, Glutamate Signaling, Stem Cell, glutamate signaling |
| UniProt ID | [P26378](https://www.uniprot.org/uniprot/P26378) |
| Ensembl ID | ENSG00000162374 |
| GeneCards | ELAVL4 |
| Human Protein Atlas | ELAVL4 |
| Associated Diseases | ALS, dementia, frontotemporal, neurodegeneration |
| Interactions | MAPT, TAU, AUTOPHAGY, PIKFYVE, DEMENTIA, RNA |
| KG Connections | 46 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ELAVL4["<b>ELAVL4</b>"]
Dementia{"Dementia"}
ELAVL4 -->|"activates"| Dementia
Neurodegeneration{"Neurodegeneration"}
ELAVL4 -->|"activates"| Neurodegeneration
Als{"Als"}
ELAVL4 -->|"activates"| Als
Ms{"Ms"}
ELAVL4 -->|"activates"| Ms
MAPT["MAPT"]
ELAVL4 -->|"activates"| MAPT
Autophagy(["Autophagy"])
ELAVL4 -->|"activates"| Autophagy
neurodegeneration["neurodegeneration"]
ELAVL4 -->|"implicated in"| neurodegeneration
PIKFYVE["PIKFYVE"]
PIKFYVE -->|"activates"| ELAVL4
style ELAVL4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Dementia | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Frontotemporal Dementia | activates | disease | 0.65 |
| MAPT | activates | gene | 0.60 |
| MAPT | regulates | gene | 0.60 |
| TAU | activates | gene | 0.60 |
| glutamate signaling | participates_in | pathway | 0.60 |
| frontotemporal | associated_with | disease | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| PIKFYVE | activates | gene | 0.60 |
| NEURON | associated_with | gene | 0.60 |
| DEMENTIA | activates | gene | 0.60 |
| Glutamate Signaling | activates | pathway | 0.60 |
| Stem Cell | activates | pathway | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| RNA | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| ALS | associated_with | disease | 0.60 |
| dementia | associated_with | disease | 0.60 |
| Stem Cell | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| MAPT | associated_with | gene | 0.50 |
| MAPT | co_expressed_with | gene | 0.50 |
| GLUTAMATE | associated_with | concept | 0.50 |
| ORGANOIDS | associated_with | concept | 0.50 |
| GLUTAMATE | activates | concept | 0.50 |
| STRESS GRANULES | activates | concept | 0.50 |
| ORGANOIDS | activates | concept | 0.50 |
| MAPT | co_mentioned | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||