pathway

Glutamate Signaling

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Glutamate Signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

258Connections

0Hypotheses

0Analyses

8Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	Glutamate Signaling
Key Genes/Proteins	FERROPTOSIS, NEURODEGENERATION, GPX4, GENES, INFLAMMATION, STIM1
Related Diseases	Temporal Lobe Epilepsy, Als, Neurodegeneration

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Als["Als"] -->|"activates"| Glutamate_Signaling["Glutamate Signaling"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| Glutamate_Signaling["Glutamate Signaling"]
    style FERROPTOSIS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    NEURODEGENERATION["NEURODEGENERATION"] -->|"therapeutic target"| Glutamate_Signaling["Glutamate Signaling"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    GPX4["GPX4"] -->|"activates"| Glutamate_Signaling["Glutamate Signaling"]
    style GPX4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    GENES["GENES"] -->|"activates"| Glutamate_Signaling["Glutamate Signaling"]
    style GENES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style Glutamate_Signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (30)

Target	Relation	Type	Str
Temporal Lobe Epilepsy	involved_in	disease	0.95
DOPAMINE	regulates	concept	0.50
Neuron	regulates	cell_type	0.50
Stem Cell	activates	cell_type	0.50
Neuron	activates	cell_type	0.50
Neuron	encodes	cell_type	0.50
Interneuron	encodes	cell_type	0.50
Interneuron	regulates	cell_type	0.50

Incoming (228)

Source	Relation	Type	Str
Als	activates	disease	0.80
FERROPTOSIS	activates	gene	0.70
NEURODEGENERATION	therapeutic_target	gene	0.70
Neurodegeneration	therapeutic_target	disease	0.70
NEURODEGENERATION	activates	gene	0.70
Neurodegeneration	activates	disease	0.70
GPX4	activates	gene	0.60
GENES	activates	gene	0.60
INFLAMMATION	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
STIM1	activates	gene	0.60
STING	regulates	gene	0.60
SLC7A11	therapeutic_target	gene	0.60
ROS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.60
Tumor	therapeutic_target	disease	0.60
Glioma	associated_with	disease	0.60
Cancer	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Glioblastoma	therapeutic_target	disease	0.60
TAU	activates	gene	0.60
ELAVL4	activates	gene	0.60
MAPT	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
PIKFYVE	activates	gene	0.60
NEURON	activates	gene	0.60
DEMENTIA	activates	gene	0.60
Dementia	activates	disease	0.60
ERK1	activates	gene	0.60
CYTOKINES	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
HO-1	activates	gene	0.60
BCL-2	activates	gene	0.60
NRF2	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
SYNAPSE	activates	gene	0.60
SYP	activates	gene	0.60
P38	activates	gene	0.60
TNF-Α	activates	gene	0.60
PROINFLAMMATORY CYTOKINES	activates	gene	0.60
GFAP	activates	gene	0.60
ROS	activates	gene	0.60
TNF	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Glutamate Signaling

Understanding Entity Pages

Wiki Pages (20)

Atypical Parkinsonism

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Corticobasal Degeneration (CBD)

nimodipine-als

GRIA3 Gene

Machado-Joseph Disease (Spinocerebellar Ataxia Type 3)

Excitotoxicity in Neurodegeneration

substance-p-nk1-signaling-neurodegeneration

amiloride-als

Kynurenine Pathway Dysregulation in 4R-Tauopathies

Amyotrophic Lateral Sclerosis (ALS)

Excitotoxicity Pathway

Mitochondria in Neurodegeneration

PTBP2 - Polypyrimidine Tract Binding Protein 2

Remyelination in Neurodegeneration

Oligodendrocyte-Neuron Metabolic Support Pathway in Neurodegeneration

ftd-tdp43-pathway

ALS Combination Therapy Matrix