concept

ENDOSOMAL SORTING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOSOMAL SORTING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

0Hypotheses

0Analyses

32Outgoing

4Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ENDOSOMAL SORTING
Key Genes/Proteins	TAU, MAPT
Related Diseases	FRONTOTEMPORAL DEMENTIA, APOPTOSIS, DEMENTIA, FERROPTOSIS
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ENDOSOMAL_SORTING["ENDOSOMAL SORTING"]
    ENDOSOMAL_SORTING -->|"interacts"| NECROPTOSIS["NECROPTOSIS"]
    ENDOSOMAL_SORTING -->|"interacts"| LYSOSOME["LYSOSOME"]
    ENDOSOMAL_SORTING -->|"activates"| TAU["TAU"]
    ENDOSOMAL_SORTING -->|"activates"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    ENDOSOMAL_SORTING -->|"interacts"| NEURON["NEURON"]
    ENDOSOMAL_SORTING -->|"interacts"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    ENDOSOMAL_SORTING -->|"interacts"| NEURODEGENERATION["NEURODEGENERATION"]
    ENDOSOMAL_SORTING -->|"interacts"| HIPPOCAMPUS["HIPPOCAMPUS"]
    CEREBRAL_CORTEX["CEREBRAL CORTEX"] -->|"interacts"| ENDOSOMAL_SORTING
    AUTOPHAGOSOME["AUTOPHAGOSOME"] -->|"interacts"| ENDOSOMAL_SORTING
    AUTOPHAGY["AUTOPHAGY"] -->|"inhibits"| ENDOSOMAL_SORTING

Outgoing (32)

Target	Relation	Type	Str
FRONTOTEMPORAL DEMENTIA	interacts_with	disease	0.65
APOPTOSIS	regulates	phenotype	0.65
FRONTOTEMPORAL DEMENTIA	implicated_in	disease	0.55
NEURON	implicated_in	cell_type	0.55
CORTEX	implicated_in	brain_region	0.55
CORTEX	depleted_in	brain_region	0.55
APOPTOSIS	implicated_in	phenotype	0.55
TAU	implicated_in	protein	0.55
NECROPTOSIS	interacts_with	process	0.50
DEMENTIA	associated_with	disease	0.45
NEURON	associated_with	cell_type	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
MAPT	associated_with	gene	0.45
FERROPTOSIS	associated_with	phenotype	0.45
NECROPTOSIS	associated_with	phenotype	0.45
PYROPTOSIS	associated_with	phenotype	0.45
AUTOPHAGY	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
TAU	associated_with	protein	0.45
SORL1	associated_with	gene	0.45
TMEM106B	associated_with	gene	0.45
TAU	activates	protein	0.35
FRONTOTEMPORAL DEMENTIA	activates	disease	0.35
NEURON	interacts_with	cell_type	0.35
MULTIPLE SCLEROSIS	interacts_with	disease	0.35
NEURODEGENERATION	interacts_with	process	0.35
HIPPOCAMPUS	interacts_with	brain_region	0.35
MICROGLIA	interacts_with	cell_type	0.35
TRAUMATIC BRAIN INJURY	interacts_with	disease	0.35
FRONTOTEMPORAL DEMENTIA	inhibits	disease	0.35
NEURON	inhibits	cell_type	0.35

Incoming (5)

Source	Relation	Type	Str
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.45
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.45
CEREBRAL CORTEX	interacts_with	brain_region	0.35
AUTOPHAGY	inhibits	process	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ENDOSOMAL SORTING

Understanding Entity Pages

Wiki Pages (20)

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