concept

NECROPTOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NECROPTOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1690Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

NECROPTOSIS is a concept in neurodegeneration research. Key relationships include: associated with, activates, co discussed. Associated with ALS, ALZHEIMER'S DISEASE, CANCER. Connected to 80 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NECROPTOSIS
Key Genes/Proteins	PARP12, RIPK1, RIPK3, TNF, MMP9, TAU
Related Diseases	AXONAL_DEGENERATION, NETS, CELL SURVIVAL, AGING
Related Pathways	NLRP3 INFLAMMASOME

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    Necroptosis["Necroptosis"]
    Als["Als"]
    Cancer["Cancer"]
    APOPTOSIS(["APOPTOSIS"])
    INFLAMMATION(["INFLAMMATION"])
    PYROPTOSIS(["PYROPTOSIS"])
    FERROPTOSIS(["FERROPTOSIS"])
    CANCER(["CANCER"])
    RIPK3(["RIPK3"])
    MLKL(["MLKL"])
    Tumor["Tumor"]
    Inflammation["Inflammation"]
    AUTOPHAGY(["AUTOPHAGY"])

    Als -->|"activates"| Necroptosis
    Cancer -->|"therapeutic target"| Necroptosis
    Als -->|"therapeutic target"| Necroptosis
    APOPTOSIS -->|"regulates"| Necroptosis
    INFLAMMATION -->|"activates"| Necroptosis
    PYROPTOSIS -->|"regulates"| Necroptosis
    FERROPTOSIS -->|"regulates"| Necroptosis
    APOPTOSIS -->|"activates"| Necroptosis
    CANCER -->|"therapeutic target"| Necroptosis
    RIPK3 -->|"regulates"| Necroptosis
    MLKL -->|"regulates"| Necroptosis
    Cancer -->|"activates"| Necroptosis
    Tumor -->|"activates"| Necroptosis
    Inflammation -->|"activates"| Necroptosis
    AUTOPHAGY -->|"regulates"| Necroptosis

    style Necroptosis fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (321)

Target	Relation	Type	Str
AXONAL_DEGENERATION	causes	phenotype	0.68
TAU	causes	protein	0.65
NEURON	targets	cell_type	0.65
TNF	causes	gene	0.65
NLRP3 INFLAMMASOME	regulates	pathway	0.65
CELL SURVIVAL	stabilizes	phenotype	0.65
ASTROCYTES	activates	cell_type	0.65
NLRP3 INFLAMMASOME	interacts_with	pathway	0.65
AGING	causes	phenotype	0.65
MLKL	activates	gene	0.65
EPILEPSY	protects_against	disease	0.65
RIPK1	phosphorylates	gene	0.65
RIPK1	treats	gene	0.65
CORTEX	activates	brain_region	0.65
CORTEX	regulates	brain_region	0.65
ASTROCYTE	protects_against	cell_type	0.65
ASTROGLIOSIS	inhibits	phenotype	0.65
RIPK1	targets	gene	0.65
MICROGLIA	regulates	cell_type	0.65
AMYLOID	degrades	protein	0.65
NEUROINFLAMMATION	exacerbates	phenotype	0.65
NEUROINFLAMMATION	interacts_with	phenotype	0.65
INFLAMMATION	degrades	phenotype	0.65
DYSMYELINATION	causes	phenotype	0.64
AMYOTROPHIC LATERAL SCLEROSIS	implicated_in	disease	0.55
TNF	implicated_in	gene	0.55
CORTEX	expressed_in	brain_region	0.55
INFLAMMATION	participates_in	phenotype	0.55
STROKE	implicated_in	disease	0.55
AMYLOID	participates_in	protein	0.55
AXONAL DEGENERATION	implicated_in	phenotype	0.55
AXONAL DEGENERATION	participates_in	phenotype	0.55
AMYLOID	implicated_in	protein	0.55
PYROPTOSIS	co_discussed	entity	0.50
RIPK1	co_discussed	entity	0.50
RIPK3	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
RIPK1	associated_with	gene	0.50
PYROPTOSIS	involved_in	process	0.50
PYROPTOSIS	regulates	process	0.50
MITOPHAGY	associated_with	process	0.50
INSULIN RESISTANCE	inhibits	process	0.50
METFORMIN	associated_with	drug	0.45
MELATONIN	associated_with	drug	0.45
INFLAMMATION	activates	process	0.44
FERROPTOSIS	activates	process	0.44
FERROPTOSIS	associated_with	process	0.44
INFLAMMATION	regulates	process	0.44
AUTOPHAGY	associated_with	process	0.44
TRAUMATIC BRAIN INJURY	co_discussed	disease	0.40

Incoming (1369)

Source	Relation	Type	Str
PARP12	regulates	gene	0.80
RIPK1	activates	protein	0.72
RIPK3	activates	protein	0.72
TNF	triggers	protein	0.70
MMP9	activates	protein	0.68
NETS	regulates	phenotype	0.68
NEURON	interacts_with	cell_type	0.65
FOXO1	inhibits	gene	0.65
FOXO1	interacts_with	gene	0.65
RIPK1	degrades	gene	0.65
MMP9	treats	gene	0.65
EXCITOTOXICITY	activates	phenotype	0.65
OXIDATIVE PHOSPHORYLATION	causes	phenotype	0.65
VALPROIC ACID	activates	drug	0.65
VALPROIC ACID	inhibits	drug	0.65
COGNITIVE DECLINE	inhibits	phenotype	0.65
WHITE MATTER	regulates	brain_region	0.65
MLKL	treats	gene	0.65
MICROGLIAL ACTIVATION	regulates	phenotype	0.65
MLKL	causes	gene	0.65
DIMETHYL FUMARATE	inhibits	drug	0.65
ER STRESS	activates	phenotype	0.65
ROS	increases_risk	phenotype	0.65
AXONAL DEGENERATION	regulates	phenotype	0.65
EXCITOTOXICITY	regulates	phenotype	0.65
ENDOPLASMIC RETICULUM STRESS	activates	phenotype	0.65
MLKL	participates_in	protein	0.64
MMP9_IN1	inhibits	drug	0.64
MITOCHONDRIA	participates_in	cell_type	0.64
CELL DEATH	implicated_in	phenotype	0.55
MMP9	implicated_in	gene	0.55
STROKE	expressed_in	disease	0.55
RIPK1	implicated_in	gene	0.55
STING	implicated_in	gene	0.55
APOPTOSIS	co_discussed	entity	0.50
MLKL	co_discussed	entity	0.50
FERROPTOSIS	co_discussed	entity	0.50
BECN1	co_discussed	entity	0.50
MMP9	co_discussed	entity	0.50
AUTOPHAGY	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
ENDOSOMAL SORTING	interacts_with	process	0.50
ALZHEIMER	associated_with	disease	0.50
PARKINSON	associated_with	disease	0.50
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.50
HUNTINGTON'S DISEASE	associated_with	disease	0.50
HUNTINGTON	associated_with	disease	0.50
MULTIPLE SCLEROSIS	associated_with	disease	0.50
STROKE	associated_with	disease	0.50
TRAUMATIC BRAIN INJURY	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NECROPTOSIS

Understanding Entity Pages

Summary

Wiki Pages (21)

necroptosis

cbs-psp-daily-action-plan

Novel Therapy Index

Parthanatos in Neurodegeneration

Alzheimer's Disease Mechanism Index

Therapeutics

deferiprone-neurodegeneration

Ferroptosis in Alzheimer's Disease

Neuronal Ceroid Lipofuscinosis (NCL)

NF-κB Signaling Pathway in Neurodegeneration

Necroptotic Neurons

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

Ferroptosis in Neurodegeneration

Necroptosis Pathway in Neurodegeneration

Cytochrome c Protein

Neurotrophic Factors in Neurodegeneration

MAPK9 Gene

Neuroinflammation Microglia

university-of-rochester