concept

TRAUMATIC BRAIN INJURY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRAUMATIC BRAIN INJURY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1493Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

TRAUMATIC BRAIN INJURY is a concept in neurodegeneration research. Key relationships include: associated with, inhibits, expressed in. Associated with ALS, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE. Connected to 29 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	TRAUMATIC BRAIN INJURY
Key Genes/Proteins	NF-KB, TNF, STING
Related Diseases	ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, ALS, MITOCHONDRIAL DYSFUNCTION, AUTISM
Related Pathways	NLRP3 INFLAMMASOME

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TRAUMATIC_BRAIN_INJURY["TRAUMATIC BRAIN INJURY"]
    TRAUMATIC_BRAIN_INJURY -->|"inhibits"| autophagy["autophagy"]
    TRAUMATIC_BRAIN_INJURY -->|"causes"| neuroinflammation["neuroinflammation"]
    TRAUMATIC_BRAIN_INJURY -->|"activates"| microglia["microglia"]
    TRAUMATIC_BRAIN_INJURY -->|"regulates"| Complement["Complement"]
    TRAUMATIC_BRAIN_INJURY -->|"inhibits"| Apoptosis["Apoptosis"]
    TRAUMATIC_BRAIN_INJURY -.biomarker for.-> Blood_Brain_Barrier["Blood-Brain Barrier"]
    TRAUMATIC_BRAIN_INJURY -->|"target for"| Neurogenesis["Neurogenesis"]
    TRAUMATIC_BRAIN_INJURY -->|"target for"| Oxidative_Stress["Oxidative Stress"]
    miR_124_3p["miR-124-3p"] -.protects against.-> TRAUMATIC_BRAIN_INJURY
    ACT001["ACT001"] -->|"treats"| TRAUMATIC_BRAIN_INJURY
    PTEN["PTEN"] -->|"regulates"| TRAUMATIC_BRAIN_INJURY
    CX3CR1["CX3CR1"] -->|"regulates"| TRAUMATIC_BRAIN_INJURY
    C1Q["C1Q"] -->|"regulates"| TRAUMATIC_BRAIN_INJURY
    CD47["CD47"] -->|"regulates"| TRAUMATIC_BRAIN_INJURY
    OVERVIEW["OVERVIEW"] -->|"target for"| TRAUMATIC_BRAIN_INJURY

Outgoing (352)

Target	Relation	Type	Str
CORTEX	destabilizes	brain_region	0.70
ALZHEIMER'S DISEASE	increases_risk	disease	0.70
WHITE MATTER	contributes_to	brain_region	0.65
ALZHEIMER'S DISEASE	causes	disease	0.65
STING	activates	gene	0.65
NLRP3 INFLAMMASOME	inhibits	pathway	0.65
MITOCHONDRIAL DYSFUNCTION	exacerbates	phenotype	0.65
TBI	interacts_with	disease	0.50
MITOPHAGY	regulates	process	0.50
TBI	associated_with	disease	0.50
TBI	causes	disease	0.50
APOPTOSIS	associated_with	process	0.50
FERROPTOSIS	associated_with	process	0.50
NECROPTOSIS	associated_with	process	0.50
PYROPTOSIS	associated_with	process	0.50
PYROPTOSIS	protects_against	process	0.50
NEUROINFLAMMATION	associated_with	process	0.50
OXIDATIVE STRESS	regulates	process	0.50
TBI	regulates	disease	0.50
NEURODEGENERATION	causes	process	0.50
DEPRESSION	associated_with	disease	0.50
AGING	associated_with	process	0.50
SYNAPTIC PLASTICITY	associated_with	process	0.50
AGING	regulates	process	0.50
SYNAPTIC PLASTICITY	regulates	process	0.50
EPILEPSY	associated_with	disease	0.50
NEURODEGENERATION	associated_with	process	0.50
OXIDATIVE STRESS	associated_with	process	0.50
MITOCHONDRIAL DYSFUNCTION	associated_with	process	0.50
APOPTOSIS	regulates	process	0.50
APOE	associated_with	gene	0.50
LRP1	associated_with	gene	0.50
CDK5	associated_with	gene	0.50
APP	associated_with	gene	0.50
TLR SIGNALING	associated_with	pathway	0.45
PFKFB3	associated_with	gene	0.45
AKT	associated_with	gene	0.45
TH	associated_with	gene	0.45
TLR4	associated_with	gene	0.45
BDNF	associated_with	gene	0.45
CREB	associated_with	gene	0.45
FOXO1	associated_with	gene	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
QUERCETIN	associated_with	drug	0.45
RAPAMYCIN	associated_with	drug	0.45
FINGOLIMOD	associated_with	drug	0.45
HEDGEHOG SIGNALING	associated_with	pathway	0.45
PREFRONTAL CORTEX	associated_with	brain_region	0.45
MICROGLIA	interacts_with	cell_type	0.44
MICROGLIA	inhibits	cell_type	0.44

Incoming (1141)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	disease	1.00
MICROGLIA	associated_with	cell_type	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
ASTROCYTES	associated_with	cell_type	1.00
ALS	associated_with	disease	0.82
NF-KB	associated_with	protein	0.82
TNF	associated_with	gene	0.66
AUTISM	associated_with	disease	0.65
MICROGLIA	causes	cell_type	0.65
NEURON	interacts_with	cell_type	0.65
TBI	interacts_with	disease	0.65
RIPK1	treats	gene	0.65
RIPK3	treats	gene	0.65
MICROGLIA	mediates	cell_type	0.65
TBI	contributes_to	disease	0.65
STROKE	exacerbates	disease	0.65
MULTIPLE SCLEROSIS	impairs	disease	0.65
NFKB	targets	gene	0.65
TBI	causes	disease	0.65
TBI	promotes	disease	0.65
TBI	impairs	disease	0.65
DEPRESSION	targets	disease	0.65
MITOPHAGY	targets	phenotype	0.65
WHITE MATTER	causes	brain_region	0.65
QUERCETIN	causes	drug	0.65
NEURONS	activates	cell_type	0.65
AUTOPHAGY	interacts_with	phenotype	0.65
NRF2	protects_against	gene	0.65
APOE	interacts_with	gene	0.65
AQP4	expression	gene	0.60
GFAP	expression	gene	0.60
CHMP4B	interacts_with	gene	0.60
CHMP4B	associated_with	gene	0.60
MIRO1	expression	gene	0.60
MIRO1	associated_with	gene	0.60
MIRO1	neurotoxic	gene	0.60
MIRO1	transports	gene	0.60
MIRO1	regulates	gene	0.60
NLRP3	neuroprotective	gene	0.60
TLR4	neuroprotective	gene	0.60
TREM2	associated_with	gene	0.60
APOE	regulates	gene	0.60
SNCA	regulates	gene	0.60
BDNF	associated_with	gene	0.60
BDNF	expression	gene	0.60
MICROGLIA	regulates	cell_type	0.58
MICROGLIA	inhibits	cell_type	0.56
MTOR	associated_with	gene	0.56
BAX	associated_with	gene	0.56
ASTROCYTES	participates_in	cell_type	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanisms drive the transition from acute to persistent neuroinf

neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.605

What molecular mechanisms explain how KCNJ2 inhibition mitigates TBI-induced neu

neurodegeneration | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TRAUMATIC BRAIN INJURY

Understanding Entity Pages

Summary

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

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Sulforaphane and Nrf2 Activation for Neuroprotection

Coenzyme Q10 for Neurodegeneration

CSF Neurofilament Light Chain (NfL) in Neurodegeneration

Epigenetic Alterations in Alzheimer's Disease

Alpha-Synuclein Prion-Like Spreading Mechanisms in Parkinson's Disease