gene

ESRRG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ESRRG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

0Analyses

22Outgoing

13Incoming

Summary

Estrogen-Related Receptor Gamma - nuclear receptor in mitochondrial function and neurodegeneration

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🧬 Gene Info

Gene Symbol	ESRRG
Full Name	Estrogen-Related Receptor Gamma
Chromosome	1q41
Protein Family	Nuclear receptor family, ERR subfamily
Protein Type	Receptor
Function	is an orphan nuclear receptor that functions as a transcriptional regulator of metabolism, mitochondrial biogenesis, and cellular energy homeostasis.
Primary Expression	tissues with high metabolic demand, including brain, heart, skeletal muscle, and kidney [@schreiber2003]
Exons	13
Gene Type	Protein-coding
UniProt ID	Q9UH77
NCBI Gene ID	2624
Ensembl ID	ENSG00000125520
OMIM	605515
GeneCards	ESRRG
Human Protein Atlas	ESRRG
Associated Diseases	Alzheimer's disease, Huntington
Interactions	DRD1, LYSOSOME, DRD2, SYNUCLEINOPATHY
KG Connections	35 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ESRRG — AlphaFold Q9UH77 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ESRRG["<b>ESRRG</b>"]
    DKK1["DKK1"]
    ESRRG -->|"regulates"| DKK1
    Alzheimer_s_disease["Alzheimer's disease"]
    ESRRG -->|"associated with"| Alzheimer_s_disease
    neurodegenerative_disease["neurodegenerative disease"]
    ESRRG -->|"regulates"| neurodegenerative_disease
    Huntington["Huntington"]
    ESRRG -->|"associated with"| Huntington
    Synucleinopathy["Synucleinopathy"]
    ESRRG -->|"inhibits"| Synucleinopathy
    AUTOPHAGY["AUTOPHAGY"]
    ESRRG -->|"associated with"| AUTOPHAGY
    DRD1["DRD1"]
    ESRRG -->|"inhibits"| DRD1
    Autophagy["Autophagy"]
    ESRRG -->|"associated with"| Autophagy
    Dopaminergic["Dopaminergic"]
    ESRRG -->|"inhibits"| Dopaminergic
    Neuron["Neuron"]
    ESRRG -->|"inhibits"| Neuron
    Protein_Aggregation["Protein Aggregation"]
    ESRRG -->|"associated with"| Protein_Aggregation
    HUNTINGTON["HUNTINGTON"]
    HUNTINGTON -->|"associated with"| ESRRG
    LYSOSOME["LYSOSOME"]
    LYSOSOME -->|"activates"| ESRRG
    GENES["GENES"]
    GENES -->|"expressed in"| ESRRG
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    MITOCHONDRIAL_DYSFUNCTION -->|"associated with"| ESRRG
    SYNUCLEINOPATHY["SYNUCLEINOPATHY"]
    SYNUCLEINOPATHY -->|"inhibits"| ESRRG
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"associated with"| ESRRG
    HUNTINGTON_S_DISEASE["HUNTINGTON'S DISEASE"]
    HUNTINGTON_S_DISEASE -->|"associated with"| ESRRG
    AND["AND"]
    AND -->|"expressed in"| ESRRG
    DRD2["DRD2"]
    DRD2 -->|"inhibits"| ESRRG
    DRD1["DRD1"]
    DRD1 -->|"inhibits"| ESRRG
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    NEURODEGENERATIVE_DISORDERS -->|"associated with"| ESRRG
    Striatum["Striatum"]
    ESRRG -->|"expressed in"| Striatum
    Neuron["Neuron"]
    ESRRG -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    ESRRG -->|"implicated in"| neurodegeneration

Outgoing (22)

Target	Relation	Type	Str
DKK1	regulates	gene	0.70
neurodegenerative disease	regulates	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
Huntington	associated_with	disease	0.65
Synucleinopathy	inhibits	disease	0.65
Huntington	encodes	disease	0.65
DRD1	inhibits	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Dopaminergic	inhibits	cell_type	0.60
Neuron	inhibits	cell_type	0.60
Protein Aggregation	associated_with	pathway	0.60
Ras	associated_with	protein	0.60
Striatum	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
NEURONS	expressed_in	concept	0.50
NEURONS	inhibits	concept	0.50
DOPAMINERGIC	inhibits	concept	0.50
SYNUCLEIN	inhibits	concept	0.50
DOPAMINERGIC NEURONS	inhibits	concept	0.50
STRIATUM	inhibits	concept	0.50
LYSOSOME	activates	gene	0.50

Incoming (13)

Source	Relation	Type	Str
DRD2	inhibits	gene	0.60
DRD1	inhibits	gene	0.60
HUNTINGTON	associated_with	gene	0.60
LYSOSOME	activates	gene	0.60
GENES	expressed_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
SYNUCLEINOPATHY	inhibits	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
HUNTINGTON'S DISEASE	associated_with	gene	0.60
AND	expressed_in	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
HUNTINGTON	encodes	gene	0.60
Autophagy	expressed_in	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found