concept

ENDOSOMAL SORTING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ENDOSOMAL SORTING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

1Hypotheses

0Analyses

27Outgoing

5Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ENDOSOMAL SORTING
Key Genes/Proteins	MAPT
Related Diseases	AMYOTROPHIC LATERAL SCLEROSIS, APOPTOSIS, AUTOPHAGY, DEMENTIA, FERROPTOSIS

Pathway Diagram

graph TD
    ENDOSOMAL_SORTING["ENDOSOMAL SORTING"]
    ENDOSOMAL_SORTING -->|"interacts"| NECROPTOSIS["NECROPTOSIS"]
    ENDOSOMAL_SORTING -->|"interacts"| LYSOSOME["LYSOSOME"]
    ENDOSOMAL_SORTING -->|"activates"| TAU["TAU"]
    ENDOSOMAL_SORTING -->|"activates"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    ENDOSOMAL_SORTING -->|"interacts"| NEURON["NEURON"]
    ENDOSOMAL_SORTING -->|"interacts"| MULTIPLE_SCLEROSIS["MULTIPLE SCLEROSIS"]
    ENDOSOMAL_SORTING -->|"interacts"| NEURODEGENERATION["NEURODEGENERATION"]
    ENDOSOMAL_SORTING -->|"interacts"| HIPPOCAMPUS["HIPPOCAMPUS"]
    CEREBRAL_CORTEX["CEREBRAL CORTEX"] -->|"interacts"| ENDOSOMAL_SORTING
    AUTOPHAGOSOME["AUTOPHAGOSOME"] -->|"interacts"| ENDOSOMAL_SORTING
    AUTOPHAGY["AUTOPHAGY"] -->|"inhibits"| ENDOSOMAL_SORTING

Outgoing (27)

Target	Relation	Type	Str
FRONTOTEMPORAL DEMENTIA	interacts_with	disease	0.65
APOPTOSIS	regulates	phenotype	0.65
FRONTOTEMPORAL DEMENTIA	implicated_in	disease	0.55
APOPTOSIS	associated_with	phenotype	0.55
TAU	associated_with	protein	0.55
NEURON	associated_with	cell_type	0.55
CORTEX	associated_with	brain_region	0.55
NECROPTOSIS	interacts_with	process	0.50
HIPPOCAMPUS	associated_with	brain_region	0.45
MAPT	associated_with	gene	0.45
DEMENTIA	associated_with	disease	0.45
FERROPTOSIS	associated_with	phenotype	0.45
NECROPTOSIS	associated_with	phenotype	0.45
PYROPTOSIS	associated_with	phenotype	0.45
AUTOPHAGY	associated_with	phenotype	0.45
SORL1	associated_with	gene	0.45
TMEM106B	associated_with	gene	0.45
NEURODEGENERATION	interacts_with	process	0.35
HIPPOCAMPUS	interacts_with	brain_region	0.35
MICROGLIA	interacts_with	cell_type	0.35
NEURON	interacts_with	cell_type	0.35
FRONTOTEMPORAL DEMENTIA	inhibits	disease	0.35
NEURON	inhibits	cell_type	0.35
TRAUMATIC BRAIN INJURY	interacts_with	disease	0.35
MULTIPLE SCLEROSIS	interacts_with	disease	0.35
TAU	activates	protein	0.35
FRONTOTEMPORAL DEMENTIA	activates	disease	0.35

Incoming (5)

Source	Relation	Type	Str
SYNJ1	regulates	gene	0.90
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.45
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.45
CEREBRAL CORTEX	interacts_with	brain_region	0.35
AUTOPHAGY	inhibits	process	0.35

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SNCA Aggregation Hijacks the Endosomal Sorting Complex Requi	0.690	neurodegeneration	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ENDOSOMAL SORTING in their description or question text

No additional research found