Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FOXO SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | FOXO SIGNALING |
Knowledge base pages for this entity
graph TD
FOXO_SIGNALING["FOXO SIGNALING"]
GENES["GENES"] -->|"regulates"| FOXO_SIGNALING
Als["Als"] -->|"activates"| FOXO_SIGNALING
AKT["AKT"] -->|"implicated in"| FOXO_SIGNALING
PI3K["PI3K"] -->|"implicated in"| FOXO_SIGNALING
IL_6["IL-6"] -->|"activates"| FOXO_SIGNALING
LDL["LDL"] -->|"activates"| FOXO_SIGNALING| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| GENES | regulates | gene | 0.70 |
| Als | activates | disease | 0.70 |
| AKT | implicated_in | gene | 0.60 |
| PI3K | implicated_in | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| HDAC1 | treats | gene | 0.60 |
| SIRT1 | activates | gene | 0.60 |
| PRKAA1 | activates | gene | 0.60 |
| ULK1 | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| AKT | therapeutic_target | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| PTEN | therapeutic_target | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| Als | regulates | disease | 0.60 |
| IL-6 | activates | gene | 0.60 |
| LDL | activates | gene | 0.60 |
| JAK | regulates | gene | 0.60 |
| Obesity | activates | disease | 0.60 |
| Nafld | activates | disease | 0.60 |
| OXIDATIVE STRESS | activates | gene | 0.60 |
| ROS | treats | gene | 0.60 |
| CANCER | treats | gene | 0.60 |
| Cancer | treats | disease | 0.60 |
| Gastric Cancer | treats | disease | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| Tumor | therapeutic_target | disease | 0.60 |
| Als | therapeutic_target | disease | 0.60 |
| Psoriasis | therapeutic_target | disease | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||