concept

CIRCADIAN CLOCK GENES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CIRCADIAN CLOCK GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

163Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CIRCADIAN CLOCK GENES
Related Diseases	Insomnia, Hepatitis, Diabetes, Als, Tumor

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CIRCADIAN_CLOCK_GENES["CIRCADIAN CLOCK GENES"]
    style CIRCADIAN_CLOCK_GENES fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    CIRCADIAN_CLOCK_GENES -->|"causes"| Insomnia["Insomnia"]
    CIRCADIAN_CLOCK_GENES -->|"regulates"| Sleep_Wake_Cycle["Sleep-Wake Cycle"]
    CIRCADIAN_CLOCK_GENES -->|"regulates"| Melatonin["Melatonin"]
    CIRCADIAN_CLOCK_GENES -->|"regulates"| Serotonin["Serotonin"]
    CIRCADIAN_CLOCK_GENES -->|"regulates"| GABA["GABA"]
    CIRCADIAN_CLOCK_GENES -->|"regulates"| Dopamine["Dopamine"]
    CIRCADIAN_CLOCK_GENES -->|"regulates"| Hepatitis["Hepatitis"]
    CIRCADIAN_CLOCK_GENES -->|"regulates"| Diabetes["Diabetes"]
    CIRCADIAN_CLOCK_GENES -->|"regulates"| Als["Als"]
    Dopamine -->|"modulates"| CIRCADIAN_CLOCK_GENES
    CIRCADIAN_RHYTHM([CIRCADIAN RHYTHM]) -->|"expressed in"| CIRCADIAN_CLOCK_GENES
    ALZHEIMER([ALZHEIMER]) -->|"expressed in"| CIRCADIAN_CLOCK_GENES
    AND([AND]) -->|"expressed in"| CIRCADIAN_CLOCK_GENES
    GFAP([GFAP]) -.->|"inhibits"| CIRCADIAN_CLOCK_GENES
    SLEEP_WAKE_CYCLE([SLEEP-WAKE CYCLE]) -.->|"inhibits"| CIRCADIAN_CLOCK_GENES
    ARNT([ARNT]) -.->|"inhibits"| CIRCADIAN_CLOCK_GENES
    AMYLOID([AMYLOID]) -.->|"inhibits"| CIRCADIAN_CLOCK_GENES
    EXERCISE([EXERCISE]) -.->|"inhibits"| CIRCADIAN_CLOCK_GENES

Outgoing (103)

Target	Relation	Type	Str
Insomnia	causes	disease	0.95
Sleep-Wake Cycle	regulates	process	0.95
Brain Homeostasis	associated_with	process	0.80
Hepatitis	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Als	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Inflammation	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Metabolic Syndrome	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Obesity	activates	disease	0.65
Diabetes	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
ALS	regulates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Cardiovascular	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
OVERVIEW	regulates	gene	0.60
AND	regulates	gene	0.60
CLOCK	regulates	gene	0.60
GENES	regulates	gene	0.60
HIF-1Α	regulates	gene	0.60
HIF	regulates	gene	0.60
CLOCK GENE	regulates	gene	0.60
GENES	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
ALZHEIMER'S DISEASE NEUROPATHOLOGY	expressed_in	gene	0.60
CLOCK	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
APP	expressed_in	gene	0.60
Circadian Rhythm	expressed_in	pathway	0.60
BMAL1	inhibits	gene	0.60
BACE1	inhibits	gene	0.60
GENES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
CLOCK	inhibits	gene	0.60

Incoming (60)

Source	Relation	Type	Str
CIRCADIAN RHYTHM	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
GFAP	inhibits	gene	0.60
CIRCADIAN RHYTHM	inhibits	gene	0.60
SLEEP-WAKE CYCLE	inhibits	gene	0.60
ARNT	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
EXERCISE	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AND	inhibits	gene	0.60
AGING	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
GENES	implicated_in	gene	0.60
SLEEP-WAKE CYCLE	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
CLOCK GENE	implicated_in	gene	0.60
GENES	regulates	gene	0.60
ARNTL	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
GENES	contributes_to	gene	0.60
SLEEP-WAKE CYCLE	regulates	gene	0.60
ALZHEIMER'S DISEASE NEUROPATHOLOGY	expressed_in	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
CLOCK GENES	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
CLOCK	contributes_to	gene	0.60
CLOCK GENE	contributes_to	gene	0.60
CLOCK GENES	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
APP	expressed_in	gene	0.60
CLOCK GENES	expressed_in	gene	0.60
CRY1	expressed_in	gene	0.60
APP/PS1	expressed_in	gene	0.60
BMAL1	associated_with	protein	0.50
CLOCK	associated_with	gene	0.50
DIABETES	associated_with	disease	0.50
CLOCK	regulates	gene	0.50
CLOCK	activates	gene	0.50
DIABETES	activates	disease	0.50
atherosclerosis	activates	disease	0.50
OBESITY	activates	disease	0.50
INSULIN	activates	concept	0.50
BMAL1	regulates	protein	0.50
CLOCK GENE	regulates	concept	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CIRCADIAN CLOCK GENES

Understanding Entity Pages

Wiki Pages (20)

Clinical Management Guide for CBS/PSP

Sleep and Circadian Dysfunction in Alzheimer's Disease

Circadian Rhythm in Neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

NPAS3 Gene

Transcriptional Regulation in Neurodegeneration

Circadian Rhythm Modulation Therapy

Advanced Glycation End Products in Neurodegeneration

Sleep-Wake Cycle

Sleep Disruption in Alzheimer's Disease

Circadian Rhythm Dysfunction in Alzheimer's Disease

sleep-disruption-neurodegeneration

DCPS - Decapping Enzyme

TGF-beta Signaling Pathway in Neurodegeneration

Circadian Rhythm Dysfunction in Corticobasal Syndrome

Tuberomammillary Nucleus in Alzheimer's Disease

ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Translocator Like (BMAL1)

NFAT3 Gene