Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Small-conductance calcium-activated potassium channel (SK3) regulating neuronal excitability
| Gene Symbol | KCNN3 |
| Full Name | Potassium Calcium-Activated Channel Subfamily N Member 3 |
| Aliases | Small Conductance Calcium-Activated Potassium Channel 3 |
| Chromosome | 4q22.1 |
| Protein Family | SK/IK calcium-activated potassium channel family |
| Protein Type | Channel |
| Function | is a member of the calcium-activated potassium channel family that plays a critical role in regulating neuronal excitability and synaptic transmission. |
| Molecular Weight | 70 kDa |
| Amino Acids | 731 aa |
| Exons | 10 |
| UniProt ID | [Q9GZP1](https://www.uniprot.org/uniprot/Q9GZP1) |
| Ensembl ID | ENSG00000163631 |
| OMIM | 609923 |
| GeneCards | KCNN3 |
| Human Protein Atlas | KCNN3 |
| Associated Diseases | Alzheimer, Inflammation, Ms, Parkinson |
| Known Drugs/Compounds | Triarylmethane-34 |
| Interactions | MAPT, SNCA |
| KG Connections | 27 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KCNN3["<b>KCNN3</b>"]
Alzheimer{"Alzheimer"}
KCNN3 -->|"associated with"| Alzheimer
Ms{"Ms"}
KCNN3 -->|"associated with"| Ms
Inflammation{"Inflammation"}
KCNN3 -->|"associated with"| Inflammation
Parkinson{"Parkinson"}
KCNN3 -->|"associated with"| Parkinson
GRIN2B["GRIN2B"]
KCNN3 -->|"associated with"| GRIN2B
CAV1["CAV1"]
KCNN3 -->|"associated with"| CAV1
GAIN["GAIN"]
KCNN3 -->|"associated with"| GAIN
CACNA1C["CACNA1C"]
KCNN3 -->|"associated with"| CACNA1C
Calcium_Signaling(["Calcium Signaling"])
KCNN3 -->|"associated with"| Calcium_Signaling
PRKN["PRKN"]
KCNN3 -->|"associated with"| PRKN
MAPT["MAPT"]
KCNN3 -->|"interacts with"| MAPT
neurodegeneration["neurodegeneration"]
KCNN3 -->|"implicated in"| neurodegeneration
CALB1["CALB1"]
CALB1 -->|"associated with"| KCNN3
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"associated with"| KCNN3
ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
ALPHA_SYNUCLEIN -->|"associated with"| KCNN3
GBA1["GBA1"]
GBA1 -->|"associated with"| KCNN3
LRRK2["LRRK2"]
LRRK2 -->|"associated with"| KCNN3
SNCA["SNCA"]
SNCA -->|"interacts with"| KCNN3
style KCNN3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| GRIN2B | associated_with | gene | 0.60 |
| CAV1 | associated_with | gene | 0.60 |
| GAIN | associated_with | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
| MAPT | interacts_with | gene | 0.60 |
| Pyramidal | associated_with | cell_type | 0.60 |
| Nmda Receptor | associated_with | protein | 0.60 |
| Calcium Signaling | associated_with | pathway | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| Tau | associated_with | protein | 0.60 |
| Prefrontal Cortex | expressed_in | brain_region | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Triarylmethane-34 | inhibits | drug | 0.75 |
| CALB1 | associated_with | gene | 0.60 |
| GBA1 | associated_with | gene | 0.60 |
| LRRK2 | associated_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| CACNA1C | associated_with | gene | 0.60 |
| GRIN2B | associated_with | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| ALPHA-SYNUCLEIN | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||