gene

KCNN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections
0Hypotheses
0Analyses
17Outgoing
10Incoming

Summary

Small-conductance calcium-activated potassium channel (SK3) regulating neuronal excitability

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🧬 Gene Info
Gene SymbolKCNN3
Full NamePotassium Calcium-Activated Channel Subfamily N Member 3
AliasesSmall Conductance Calcium-Activated Potassium Channel 3
Chromosome4q22.1
Protein FamilySK/IK calcium-activated potassium channel family
Protein TypeChannel
Functionis a member of the calcium-activated potassium channel family that plays a critical role in regulating neuronal excitability and synaptic transmission.
Molecular Weight70 kDa
Amino Acids731 aa
Exons10
UniProt ID[Q9GZP1](https://www.uniprot.org/uniprot/Q9GZP1)
Ensembl IDENSG00000163631
OMIM609923
GeneCardsKCNN3
Human Protein AtlasKCNN3
Associated DiseasesAlzheimer, Inflammation, Ms, Parkinson
Known Drugs/CompoundsTriarylmethane-34
InteractionsMAPT, SNCA
KG Connections27 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

KCNN3 — Potassium Calcium-Activated Channel Subfamily N Member 3

gene · 1337 words

Ion Channel Dysfunction in Parkinson's Disease

mechanism · 3382 words

CALB1 (Calbindin 1)

gene · 2669 words

sk4-protein

protein · 1994 words

KCNN4 — Potassium Calcium-Activated Channel Subfamily N Member 4

gene · 1374 words

SK3 Protein (KCNN3)

protein · 1129 words

Pathway Diagram

graph TD
    KCNN3["<b>KCNN3</b>"]
    Alzheimer{"Alzheimer"}
    KCNN3 -->|"associated with"| Alzheimer
    Ms{"Ms"}
    KCNN3 -->|"associated with"| Ms
    Inflammation{"Inflammation"}
    KCNN3 -->|"associated with"| Inflammation
    Parkinson{"Parkinson"}
    KCNN3 -->|"associated with"| Parkinson
    GRIN2B["GRIN2B"]
    KCNN3 -->|"associated with"| GRIN2B
    CAV1["CAV1"]
    KCNN3 -->|"associated with"| CAV1
    GAIN["GAIN"]
    KCNN3 -->|"associated with"| GAIN
    CACNA1C["CACNA1C"]
    KCNN3 -->|"associated with"| CACNA1C
    Calcium_Signaling(["Calcium Signaling"])
    KCNN3 -->|"associated with"| Calcium_Signaling
    PRKN["PRKN"]
    KCNN3 -->|"associated with"| PRKN
    MAPT["MAPT"]
    KCNN3 -->|"interacts with"| MAPT
    neurodegeneration["neurodegeneration"]
    KCNN3 -->|"implicated in"| neurodegeneration
    CALB1["CALB1"]
    CALB1 -->|"associated with"| KCNN3
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| KCNN3
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"associated with"| KCNN3
    GBA1["GBA1"]
    GBA1 -->|"associated with"| KCNN3
    LRRK2["LRRK2"]
    LRRK2 -->|"associated with"| KCNN3
    SNCA["SNCA"]
    SNCA -->|"interacts with"| KCNN3
    style KCNN3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

TargetRelationTypeStr
Alzheimerassociated_withdisease0.65
Msassociated_withdisease0.65
Inflammationassociated_withdisease0.65
Parkinsonassociated_withdisease0.65
GRIN2Bassociated_withgene0.60

Incoming (10)

SourceRelationTypeStr
Triarylmethane-34inhibitsdrug0.75
CALB1associated_withgene0.60
GBA1associated_withgene0.60
LRRK2associated_withgene0.60
SNCAinteracts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found