Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KDM1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | KDM1A |
| Full Name | Lysine Specific Demethylase 1A |
| Aliases | Lysine Specific Demethylase 1A (LSD1 |
| Chromosome | 1p36.22 |
| Protein Family | LSD1 family (Flavin-dependent amine oxidase) |
| Function | is a crucial epigenetic regulator that catalyzes the removal of methyl groups from histone lysine residues. |
| Pathways | Ferroptosis, bone metabolism, epigenetic regulation |
| UniProt ID | O60341 |
| NCBI Gene ID | 23028 |
| Ensembl ID | ENSG00000136867 |
| OMIM | 607042 |
| GeneCards | KDM1A |
| Human Protein Atlas | KDM1A |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Neurodevelopmental Disorders |
| Interactions | SLC7A11, HDAC2, EP300, KDM6A, FERROPTOSIS |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KDM1A["<b>KDM1A</b>"]
Cancer{"Cancer"}
KDM1A -->|"regulates"| Cancer
Tumor{"Tumor"}
KDM1A -->|"inhibits"| Tumor
Aging{"Aging"}
KDM1A -->|"therapeutic target"| Aging
Ms{"Ms"}
KDM1A -->|"therapeutic target"| Ms
CANCER["CANCER"]
KDM1A -->|"regulates"| CANCER
SLC7A11["SLC7A11"]
KDM1A -->|"activates"| SLC7A11
FERROPTOSIS["FERROPTOSIS"]
KDM1A -->|"activates"| FERROPTOSIS
Ferroptosis(["Ferroptosis"])
KDM1A -->|"activates"| Ferroptosis
HDAC2["HDAC2"]
KDM1A -->|"inhibits"| HDAC2
DNMT1["DNMT1"]
KDM1A -->|"therapeutic target"| DNMT1
EHMT2["EHMT2"]
KDM1A -->|"therapeutic target"| EHMT2
EP300["EP300"]
KDM1A -->|"inhibits"| EP300
style KDM1A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| bone metabolism | regulates | process | 0.70 |
| Cancer | regulates | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| SLC7A11 | activates | gene | 0.60 |
| HDAC2 | inhibits | gene | 0.60 |
| DNMT1 | therapeutic_target | gene | 0.60 |
| EHMT2 | therapeutic_target | gene | 0.60 |
| EP300 | inhibits | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| AMPK | therapeutic_target | gene | 0.60 |
| Epigenetic | inhibits | pathway | 0.60 |
| Insulin Signaling | therapeutic_target | pathway | 0.60 |
| Notch | therapeutic_target | pathway | 0.60 |
| KDM6A | activates | gene | 0.55 |
| epigenetic regulation | participates_in | pathway | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||