gene

LGMN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LGMN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

34Connections

0Hypotheses

0Analyses

26Outgoing

8Incoming

Summary

Comprehensive page on LGMN (Legumain) in neurodegeneration, protein degradation, and lysosomal function

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🧬 Gene Info

Gene Symbol	LGMN
Full Name	Legumain (Asparagine Endopeptidase)
Aliases	Legumain
Chromosome	14q32.12
Protein Type	Cysteine protease, peptidase family C13
Function	The structure features
Primary Expression	Ubiquitous, high in kidney, brain, immune cells
Subcellular Localization	3:
Molecular Weight	56 kDa (proenzyme), 46 kDa (active enzyme)
Pathways	Autophagy, Chaperone, Ferroptosis
UniProt ID	Q99538
NCBI Gene ID	5648
Ensembl ID	ENSG00000100600
OMIM	607216
GeneCards	LGMN
Human Protein Atlas	LGMN
Associated Diseases	neurodegeneration
Interactions	HK2, STAT3, ALZHEIMER, AND, NEURODEGENERATIVE DISEASES, ALZHEIMER'S DISEASE
KG Connections	34 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: LGMN — AlphaFold Q99538 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LGMN Gene

gene · 1523 words

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Genes

index · 271 words

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Pathway Diagram

graph TD
    LGMN["<b>LGMN</b>"]
    Ms{"Ms"}
    LGMN -->|"interacts with"| Ms
    HK2["HK2"]
    LGMN -->|"interacts with"| HK2
    SQSTM1["SQSTM1"]
    LGMN -->|"associated with"| SQSTM1
    KEAP1["KEAP1"]
    LGMN -->|"associated with"| KEAP1
    CTSD["CTSD"]
    LGMN -->|"associated with"| CTSD
    neurodegeneration["neurodegeneration"]
    LGMN -->|"implicated in"| neurodegeneration
    style LGMN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

Target	Relation	Type	Str
Ms	interacts_with	disease	0.65
Ischemia	activates	disease	0.65
Alzheimer	activates	disease	0.65
Longevity	activates	disease	0.65
Aging	activates	disease	0.65
ALS	activates	disease	0.65
Tumor	inhibits	disease	0.65
Glioblastoma	activates	disease	0.65
HK2	interacts_with	gene	0.60
SQSTM1	associated_with	gene	0.60
KEAP1	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
STAT3	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Chaperone	activates	pathway	0.60
ALZHEIMER	activates	gene	0.60
AND	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AEP	associated_with	gene	0.60
glioblastoma	regulates	disease	0.60
Wnt signaling	participates_in	pathway	0.60
glioblastoma	activates	disease	0.60
Macrophage	expressed_in	cell_type	0.55
macrophages	expressed_in	cell_type	0.55

Incoming (8)

Source	Relation	Type	Str
GPX4	activates	gene	0.60
AKT	activates	gene	0.60
GBM	activates	gene	0.60
STAT3	activates	gene	0.60
GBM	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
AGING	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found