concept

SLC16A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC16A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

166Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SLC16A2 Gene (MCT8)
Summary	Thyroid hormone transporter essential for brain development; mutations cause Allan-Herndon-Dudley syndrome
Key Genes/Proteins	TH, MCT8
Related Diseases	Mct8 Deficiency, Cancer, Ms, Als
Related Pathways	Astrocytic Lactate Shuttle Enhancement for Grid Ce

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SLC16A2["SLC16A2"]
    SLC16A2 -->|"regulates"| Astrocytic_Lactate_Shuttle_Enh["Astrocytic Lactate Shuttle Enhancement for Grid Ce"]
    SLC16A2 -->|"target for"| Cancer["Cancer"]
    SLC16A2 -->|"target for"| Ms["Ms"]
    SLC16A2 -->|"regulates"| Tau_Propagation["Tau Propagation"]
    SLC16A2 -->|"target for"| GSS["GSS"]
    SLC16A2 -->|"target for"| JUN["JUN"]
    SLC16A2 -->|"target for"| MICRORNAS["MICRORNAS"]
    h_5ff6c5ca["h-5ff6c5ca"] -->|"targets"| SLC16A2
    JUN -->|"target for"| SLC16A2
    ACSL5["ACSL5"] -->|"target for"| SLC16A2
    GSS -->|"activates"| SLC16A2
    MICRORNAS -->|"activates"| SLC16A2
    SLC16A1["SLC16A1"] -->|"transports"| SLC16A2
    CYP2E1["CYP2E1"] -->|"activates"| SLC16A2

Outgoing (104)

Target	Relation	Type	Str
Mct8 Deficiency	causes	disease	1.00
THYROID HORMONE METABOLISM	involved_in	entity	0.90
Astrocytic Lactate Shuttle Enhancement for Grid Ce	regulates	mechanism	0.70
TH	transported_by	gene	0.70
Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Cancer	activates	disease	0.65
Cancer	transports	disease	0.65
Als	causes	disease	0.65
Als	associated_with	disease	0.65
Aging	causes	disease	0.65
ALS	transports	disease	0.65
ALS	associated_with	disease	0.65
ALS	causes	disease	0.65
Als	transports	disease	0.65
Tau Propagation	regulates	biological_process	0.60
SLC16A1	associated_with	gene	0.60
GSS	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
JUN	transports	gene	0.60
neurodegeneration	implicated_in	disease	0.60
Allan-Herndon-Dudley syndrome	causes	disease	0.60
cerebral palsy	associated_with	disease	0.60
neurodevelopmental impairment	contributes_to	disease	0.60
brain	expressed_in	brain_region	0.60
X chromosome	associated_with	pathway	0.60
cerebral hypothyroidism	contributes_to	disease	0.60
SLC16 family	involved_in	pathway	0.60
intellectual disability	contributes_to	disease	0.60
thyroid function	regulates	pathway	0.60
SLC16A1	transports	gene	0.60
GNAO1	associated_with	gene	0.60
ATL1	associated_with	gene	0.60
Rb	therapeutic_target	protein	0.60
Rb	transports	protein	0.60
SATB2	associated_with	gene	0.60
Rb	associated_with	protein	0.60
Rb	causes	protein	0.60
TH	associated_with	gene	0.60
SPAST	associated_with	gene	0.60
TH	translocates_to	gene	0.60
SLCO1C1	activates	gene	0.60
TH	disrupts	gene	0.60
neurodegeneration	transported_by	disease	0.60
SLCO1C1	interacts_with	gene	0.60
TH	interacts_with	gene	0.60
neurodegeneration	interacts_with	disease	0.60
MICRORNAS	therapeutic_target	gene	0.60
CANCER	transports	gene	0.60

Incoming (62)

Source	Relation	Type	Str
Mct8 Deficiency	biomarker_for	disease	1.00
h-5ff6c5ca	targets_gene	hypothesis	0.90
h-5ff6c5ca	targets	hypothesis	0.80
MCT8	translocates_to	gene	0.70
JUN	therapeutic_target	gene	0.60
SLC16A1	associated_with	gene	0.60
GSS	activates	gene	0.60
JUN	activates	gene	0.60
SLC16A1	transports	gene	0.60
JUN	transports	gene	0.60
SLC16 FAMILY	transports	gene	0.60
GSS	therapeutic_target	gene	0.60
SPAST	associated_with	gene	0.60
COL4A1	associated_with	gene	0.60
SATB2	associated_with	gene	0.60
ATL1	associated_with	gene	0.60
PDHX	associated_with	gene	0.60
GNAO1	associated_with	gene	0.60
POLR2A	associated_with	gene	0.60
ACSL5	therapeutic_target	gene	0.60
MICRORNAS	activates	gene	0.60
CYP2E1	activates	gene	0.60
ACSL5	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
SLC16A3	transports	gene	0.60
SLC16A10	transports	gene	0.60
AND	transports	gene	0.60
MIR-375	activates	gene	0.60
AND	associated_with	gene	0.60
SLC16A10	associated_with	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
MIR-375	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
AND	expressed_in	gene	0.60
SLC16A3	therapeutic_target	gene	0.60
CYP2E1	therapeutic_target	gene	0.60
MCT8	transports	gene	0.60
MCT8	causes	gene	0.60
SLC16A10	translocates_to	gene	0.60
MCT8	associated_with	gene	0.60
MCT8	activates	gene	0.60
MCT8	interacts_with	gene	0.60
C1Q	activates	gene	0.55
phagocytosis	activates	process	0.55
MCU	debate_co_mention	gene	0.45
PPARGC1A	debate_co_mention	gene	0.45
RELN	debate_co_mention	gene	0.45
oxidative stress	debate_co_mention	process	0.45
PPARGC1A	co_discussed	gene	0.40
RELN	co_discussed	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener	0.412	neurodegeneration	Selective vulnerability of entorhinal co

Mentioning Analyses (1)

Scientific analyses that reference this entity

Selective vulnerability of entorhinal cortex layer II neurons in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.484

Related Papers (17)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
miR-375 protects against acetaminophen-induced acute liver failure by orchestrat [PMID:40598772]	Wang Y, Liu J, Zhu S, Hu S, Chen X, Mand	Mol Ther	2025	1
Defective thyroid hormone transport to the brain leads to astroglial alterations [PMID:39097035]	Guillén-Yunta M, García-Aldea Á, Valcárc	Neurobiol Dis	2024	1
The SLC16 gene family - structure, role and regulation in health and disease. [PMID:23506875]	Halestrap AP	Mol Aspects Med	2013	1
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Tiratricol: First Approval. [PMID:40549098]	["Lamb Y"]	Drugs	2025	0
Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1. [PMID:40680733]	Ge Y, Dou T, Nguyen TU, Yadav GP, Wensel	Cell	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
The interactions between monocarboxylate transporter genes MCT1, MCT2, and MCT4 [PMID:39934699]	Maculewicz E, Mastalerz A, Garbacz A, Mr	BMC genomics	2025	0
Adrenergic regulation of astroglial aerobic glycolysis and lipid metabolism: Tow [PMID:37094775]	["Zorec R", "Vardjan N"]	Neurobiology of disease	2023	0
Tsh Induces Agrp1 Neuron Proliferation in Oatp1c1-Deficient Zebrafish. [PMID:36150888]	Wasserman-Bartov T, Admati I, Lebenthal-	The Journal of neuroscience :	2022	0
The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer. [PMID:34097251]	Sohrabi E, Moslemi M, Rezaie E, Nafissi	Genes & genomics	2021	0
Thyroid Hormone Transporters. [PMID:31754699]	["Groeneweg S", "van Geest F", "Peeters	Endocrine reviews	2020	0
Neural Alterations and Hyperactivity of the Hypothalamic-Pituitary-Thyroid Axis [PMID:31797746]	["Admati I", "Wasserman-Bartov T", "Tovi	Thyroid : official journal of	2020	0
Disease characteristics of MCT8 deficiency: an international, retrospective, mul [PMID:32559475]	Groeneweg S, van Geest FS, Abacı A, Alca	The lancet. Diabetes & endocri	2020	0
Nonbiological maternal risk factor for low birth weight on Latin America: a syst [PMID:23386023]	["da Silva T"]	Einstein (Sao Paulo, Brazil)	2012	0
Thyroid hormone transporters in the brain. [PMID:20879691]	Braun D, Wirth EK, Schweizer U	Reviews in the neurosciences	2010	0
Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome [PMID:16849530]	["Eckerdt F", "Strebhardt K"]	Cancer research	2006	0

SLC16A2

Understanding Entity Pages

Wiki Pages (18)

SLC16A2 Gene (MCT8)

Entorhinal Cortex

Lactate Lactylation in Neurodegeneration

Entorhinal Cortex Layer II

Lundbeck/Genentech Bispecific Brain Shuttle Antibodies

Entorhinal Cortex Layer II Neurons

Allan-Herndon-Dudley Syndrome

Entorhinal Cortex Layer II Neurons

SPAST

Lateral Superior Olive (LSO) Neurons

ATL1

Medial Nucleus of the Trapezoid Body (MNTB) Neurons

Ventral Tegmental Area Dopamine Neurons in Neurodegeneration

Trapezoid Body Complex

Medial Forebrain Bundle in Neurodegeneration

Cerebellar Interneurons in Neurodegeneration

Genes