Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NFATC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NFATC2 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Cancer. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | NFATc2 / NFATC2 |
| Aliases | NFAT1, NF-AT2, NFATc2 |
| Chromosome | 20q13.12 |
| Protein Type | Transcription Factor |
| Function | is a member of the NFAT (Nuclear Factor of Activated T cells) transcription factor family involved in calcium-dependent gene regulation. |
| Subcellular Localization | and protein interactions |
| Amino Acids | 925 aa |
| Pathways | cascade: [@crabtree2001] |
| UniProt ID | Q13469 |
| NCBI Gene ID | 4778 |
| Protein | Nuclear factor of activated T-cells, cytoplasmic 2 |
| Gene | Function |
| BDNF | Neurotrophin |
| COX-2 | Inflammatory enzyme |
| iNOS | Nitric oxide synthase |
| Associated Diseases | neurodegeneration |
| Interactions | CTSB, MICROGLIA, PI3K, TPX2, LC3, AURKA |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NFATC2["NFATC2"]
Cancer{"Cancer"}
NFATC2 -->|"activates"| Cancer
Als{"Als"}
NFATC2 -->|"activates"| Als
Neuroinflammation{"Neuroinflammation"}
NFATC2 -->|"regulates"| Neuroinflammation
Inflammation{"Inflammation"}
NFATC2 -->|"regulates"| Inflammation
Parkinson{"Parkinson"}
NFATC2 -->|"regulates"| Parkinson
Ms{"Ms"}
NFATC2 -->|"regulates"| Ms
NFATC2 -->|"regulates"| Als
CTSB["CTSB"]
NFATC2 -->|"activates"| CTSB
Autophagy(["Autophagy"])
NFATC2 -->|"activates"| Autophagy
Angiogenesis(["Angiogenesis"])
NFATC2 -->|"activates"| Angiogenesis
NEUROINFLAMMATION["NEUROINFLAMMATION"]
NFATC2 -->|"regulates"| NEUROINFLAMMATION
AND["AND"]
NFATC2 -->|"regulates"| AND
GENES["GENES"]
NFATC2 -->|"regulates"| GENES
MICROGLIA["MICROGLIA"]
NFATC2 -->|"activates"| MICROGLIA
IFN["IFN"]
NFATC2 -->|"regulates"| IFN| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| Inflammation | regulates | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| CTSB | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Angiogenesis | activates | pathway | 0.60 |
| NEUROINFLAMMATION | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| IFN | regulates | gene | 0.60 |
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| T Cell | regulates | cell_type | 0.60 |
| Microglia | activates | cell_type | 0.60 |
| Pericyte | regulates | cell_type | 0.60 |
| Endothelial | regulates | cell_type | 0.60 |
| Interferon | regulates | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PI3K | activates | gene | 0.60 |
| TPX2 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| AURKA | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| VEGFA | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| IFN | regulates | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||