gene

NFATC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFATC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections
0Hypotheses
0Analyses
21Outgoing
12Incoming

Summary

NFATC2 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Cancer. Connected to 14 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolNFATc2 / NFATC2
AliasesNFAT1, NF-AT2, NFATc2
Chromosome20q13.12
Protein TypeTranscription Factor
Functionis a member of the NFAT (Nuclear Factor of Activated T cells) transcription factor family involved in calcium-dependent gene regulation.
Subcellular Localizationand protein interactions
Amino Acids925 aa
Pathwayscascade: [@crabtree2001]
UniProt IDQ13469
NCBI Gene ID4778
ProteinNuclear factor of activated T-cells, cytoplasmic 2
GeneFunction
BDNFNeurotrophin
COX-2Inflammatory enzyme
iNOSNitric oxide synthase
Associated Diseasesneurodegeneration
InteractionsCTSB, MICROGLIA, PI3K, TPX2, LC3, AURKA
KG Connections33 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NFATC2 — AlphaFold Q13469 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

NFATc2 — Nuclear Factor of Activated T Cells 2

gene · 1544 words

NFAT4 — Nuclear Factor of Activated T-cells 4

gene · 2496 words

nfat-pathway-modulators-neurodegeneration

therapeutic · 2077 words

CREB-independent Neuronal Survival Pathways

mechanism · 1539 words

CREB-Independent Neuronal Survival Pathways in Neurodegeneration

mechanism · 1441 words

NFAT1 Gene

gene · 730 words

Pathway Diagram

graph TD
    NFATC2["NFATC2"]
    Cancer{"Cancer"}
    NFATC2 -->|"activates"| Cancer
    Als{"Als"}
    NFATC2 -->|"activates"| Als
    Neuroinflammation{"Neuroinflammation"}
    NFATC2 -->|"regulates"| Neuroinflammation
    Inflammation{"Inflammation"}
    NFATC2 -->|"regulates"| Inflammation
    Parkinson{"Parkinson"}
    NFATC2 -->|"regulates"| Parkinson
    Ms{"Ms"}
    NFATC2 -->|"regulates"| Ms
    NFATC2 -->|"regulates"| Als
    CTSB["CTSB"]
    NFATC2 -->|"activates"| CTSB
    Autophagy(["Autophagy"])
    NFATC2 -->|"activates"| Autophagy
    Angiogenesis(["Angiogenesis"])
    NFATC2 -->|"activates"| Angiogenesis
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NFATC2 -->|"regulates"| NEUROINFLAMMATION
    AND["AND"]
    NFATC2 -->|"regulates"| AND
    GENES["GENES"]
    NFATC2 -->|"regulates"| GENES
    MICROGLIA["MICROGLIA"]
    NFATC2 -->|"activates"| MICROGLIA
    IFN["IFN"]
    NFATC2 -->|"regulates"| IFN

Outgoing (21)

TargetRelationTypeStr
Canceractivatesdisease0.65
Alsactivatesdisease0.65
Neuroinflammationregulatesdisease0.65
Inflammationregulatesdisease0.65
Parkinsonregulatesdisease0.65

Incoming (12)

SourceRelationTypeStr
PI3Kactivatesgene0.60
TPX2activatesgene0.60
LC3activatesgene0.60
AURKAactivatesgene0.60
AKTactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found