gene

SNRNP70

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SNRNP70: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

57Connections

0Hypotheses

0Analyses

42Outgoing

15Incoming

Summary

SNRNP70 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, expressed in, implicated in. Associated with AD, ALI, ALS. Connected to 45 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SNRNP70
Full Name	Small nuclear ribonucleoprotein 70kDa
Chromosome	19q13.33
Function	SNRNP70 (U1-70K, RNPU1L) is a core component of the U1 small nuclear ribonucleoprotein (snRNP) complex, which plays an essential role in pre-mRNA splicing
Molecular Weight	70kDa
UniProt ID	[P08621](https://www.uniprot.org/uniprot/P08621)
Ensembl ID	ENSG00000106462
GeneCards	SNRNP70
Human Protein Atlas	SNRNP70
Early Recognition	The U1 snRNP recognizes the 5' splice site before the 3' splice site is recognized.
Cross-intron Recognition	SNRNP70 helps bridge the 5' and 3' splice sites together.
Catalysis	The assembled spliceosome catalyzes two transesterification reactions to remove introns.
Recycling	SNRNP70 is released and recycled for new splicing events.
Associated Diseases	AD, ALI, Als, Alzheimer, Alzheimer's disease, ILD
Interactions	NTN3, TARDBP, TAU, NTN1, DNA, PTN
KG Connections	57 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SNRNP70["<b>SNRNP70</b>"]
    TREM2["TREM2"]
    SNRNP70 -->|"associated with"| TREM2
    MHC_I["MHC-I"]
    SNRNP70 -->|"upregulates"| MHC_I
    Alzheimer{"Alzheimer"}
    SNRNP70 -->|"expressed in"| Alzheimer
    Als{"Als"}
    SNRNP70 -->|"expressed in"| Als
    SNRNP70 -->|"associated with"| Als
    SNRNP70 -->|"associated with"| Alzheimer
    ALS{"ALS"}
    SNRNP70 -->|"expressed in"| ALS
    JUN["JUN"]
    SNRNP70 -->|"expressed in"| JUN
    NTN3["NTN3"]
    SNRNP70 -->|"interacts with"| NTN3
    Endocytosis(["Endocytosis"])
    SNRNP70 -->|"expressed in"| Endocytosis
    Complement(["Complement"])
    SNRNP70 -->|"expressed in"| Complement
    Exocytosis(["Exocytosis"])
    SNRNP70 -->|"expressed in"| Exocytosis
    TARDBP["TARDBP"]
    TARDBP -->|"interacts with"| SNRNP70
    NTN1["NTN1"]
    NTN1 -->|"interacts with"| SNRNP70
    JUN -->|"associated with"| SNRNP70
    NTN3 -->|"interacts with"| SNRNP70
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"expressed in"| SNRNP70
    PTN["PTN"]
    PTN -->|"interacts with"| SNRNP70
    AMYLOID["AMYLOID"]
    AMYLOID -->|"interacts with"| SNRNP70
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"expressed in"| SNRNP70
    JUN -->|"expressed in"| SNRNP70
    DNA["DNA"]
    DNA -->|"interacts with"| SNRNP70
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"expressed in"| SNRNP70
    style SNRNP70 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (42)

Target	Relation	Type	Str
TREM2	associated_with	protein	0.80
MHC-I	upregulates	protein	0.70
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
JUN	expressed_in	gene	0.60
NTN3	interacts_with	gene	0.60
TARDBP	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
NTN1	interacts_with	gene	0.60
Endocytosis	expressed_in	pathway	0.60
Complement	expressed_in	pathway	0.60
Exocytosis	expressed_in	pathway	0.60
DNA	interacts_with	gene	0.60
Amyloid	interacts_with	pathway	0.60
Complement	associated_with	pathway	0.60
Endocytosis	associated_with	pathway	0.60
Exocytosis	associated_with	pathway	0.60
Protein Aggregation	associated_with	pathway	0.60
Protein Aggregation	expressed_in	pathway	0.60
PTN	interacts_with	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
AMYLOID	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
NEURODEGENERATIVE DISORDERS	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
App	expressed_in	protein	0.60
TAR	interacts_with	gene	0.60
AD	implicated_in	disease	0.50
ALI	implicated_in	disease	0.50
Als	implicated_in	disease	0.50
Alzheimer	implicated_in	disease	0.50
Alzheimer's disease	implicated_in	disease	0.50
ILD	implicated_in	disease	0.50
RA	implicated_in	disease	0.50
SS	implicated_in	disease	0.50
disease	implicated_in	disease	0.50
Proteins	interacts_with	protein	0.50
AMYLOID-β	interacts_with	concept	0.50
Rna Splicing	interacts_with	gene	0.50

Incoming (15)

Source	Relation	Type	Str
TARDBP	interacts_with	gene	0.60
NTN1	interacts_with	gene	0.60
JUN	associated_with	gene	0.60
NTN3	interacts_with	gene	0.60
JUN	expressed_in	gene	0.60
BAD	expressed_in	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
PTN	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
DNA	interacts_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
AND	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SNRNP70

Understanding Entity Pages

Summary

Wiki Pages (7)

SNRNP70 Gene

Protein Aggregation Seeding

RNA Splicing Defects in Neurodegeneration

NTN3 Gene

SNRNP70 Protein