gene

TPR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TPR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections

0Hypotheses

0Analyses

44Outgoing

23Incoming

Summary

TPR is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, treats. Associated with Als, Cancer, Hypertension. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TPR
Full Name	Translocated Promoter Region
Chromosome	1
Function	The Translocated Promoter Region (TPR) is a large filamentous protein component of the nuclear pore complex (NPC) that extends into the nuclear basket.
Amino Acids	163 aa
Ensembl ID	ENSG00000158477
GeneCards	TPR
Human Protein Atlas	TPR
Nuclear basket formation	TPR forms the core structure of the nuclear basket, regulating nuclear pore permeability
mRNA export	TPR facilitates the export of mature mRNAs through interactions with the mRNA export receptor NXF1/TAP[@cheng2021]
Nuclear export of proteins	TPR regulates the export of ribosomal proteins and other large cargo
Chromatin organization	TPR anchors chromatin to the nuclear envelope and participates in gene regulation
DNA damage response	TPR recruits DNA repair proteins to nuclear pores following damage
Brain	High expression in neurons throughout the cortex, hippocampus, and basal ganglia
Neuronal localization	Nuclear envelope, with extension into the nucleoplasm
Associated Diseases	neurodegeneration
Interactions	DDIT3, SST, RANK, NEURODEGENERATION, AND, INFLAMMATION
KG Connections	67 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TPR["TPR"]
    Als{"Als"}
    TPR -->|"activates"| Als
    Hypertension{"Hypertension"}
    TPR -->|"activates"| Hypertension
    Cancer{"Cancer"}
    TPR -->|"treats"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    TPR -->|"interacts_with"| Neurodegeneration
    Inflammation{"Inflammation"}
    TPR -->|"interacts_with"| Inflammation
    Ms{"Ms"}
    TPR -->|"therapeutic_target"| Ms
    TPR -->|"therapeutic_target"| Cancer
    Pain{"Pain"}
    TPR -->|"interacts_with"| Pain
    DDIT3["DDIT3"]
    TPR -->|"activates"| DDIT3
    CANCER["CANCER"]
    TPR -->|"treats"| CANCER
    NEURODEGENERATION["NEURODEGENERATION"]
    TPR -->|"interacts_with"| NEURODEGENERATION
    AND["AND"]
    TPR -->|"interacts_with"| AND
    INFLAMMATION["INFLAMMATION"]
    TPR -->|"interacts_with"| INFLAMMATION
    INFLAMMATION -->|"interacts_with"| TPR
    CANCER -->|"therapeutic_target"| TPR

Outgoing (44)

Target	Relation	Type	Str
Als	activates	disease	0.65
Hypertension	activates	disease	0.65
Cancer	treats	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Pain	interacts_with	disease	0.65
Cancer	activates	disease	0.65
Als	therapeutic_target	disease	0.65
DDIT3	activates	gene	0.60
RANK	therapeutic_target	gene	0.60
CALM1	associated_with	gene	0.60
NEFH	associated_with	gene	0.60
KIF5B	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
PVALB	associated_with	gene	0.60
SST	associated_with	gene	0.60
GAP43	associated_with	gene	0.60
NEFL	associated_with	gene	0.60
KIF15	associated_with	gene	0.60
AURKB	associated_with	gene	0.60
RANK	interacts_with	gene	0.60
ESR1	associated_with	gene	0.60
RB1	associated_with	gene	0.60
PCDH15	associated_with	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
FGFR2	associated_with	gene	0.60
Rb	associated_with	protein	0.60
neurodegeneration	interacts_with	disease	0.60
CANCER	treats	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
CANCER	activates	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
App	therapeutic_target	protein	0.60
DNA	therapeutic_target	gene	0.60
PBRM1	associated_with	gene	0.60
Fgf	associated_with	protein	0.60
tauopathy	activates	disease	0.55
SST	interacts_with	gene	0.50

Incoming (23)

Source	Relation	Type	Str
KIF15	associated_with	gene	0.60
NEFL	associated_with	gene	0.60
AURKB	associated_with	gene	0.60
CALM1	associated_with	gene	0.60
RANK	therapeutic_target	gene	0.60
PVALB	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
GAP43	associated_with	gene	0.60
KIF5B	associated_with	gene	0.60
NEFH	associated_with	gene	0.60
SST	associated_with	gene	0.60
MKI67	associated_with	gene	0.60
KIF5A	associated_with	gene	0.60
NTRK2	associated_with	gene	0.60
TPM3	associated_with	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
CANCER	activates	gene	0.60
HSP90	activates	gene	0.55
PPP5C	activates	gene	0.55
RANK	regulates	gene	0.50
PVALB	co_expressed_with	gene	0.50
SST	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TPR

Understanding Entity Pages

Summary

Wiki Pages (21)

TPR — Translocated Promoter Region

DNAJC13 — DnaJ Heat Shock Protein Family Member C13

Protein O-GlcNAcylation Pathway in Neurodegeneration

Heat Shock Protein Response Pathway in Neurodegeneration

PPP5C — Protein Phosphatase 5 Catalytic Subunit

KMT2E Gene (Lysine Methyltransferase 2E)

Chaperone-Mediated Proteostasis Disease Comparison

FANCF Gene

KLC1 — Kinesin Light Chain 1

GEMIN5 Gene

PCDH15 — Protocadherin 15

COA8 Gene - Cytochrome c Oxidase Assembly Factor 8

HERC2 Gene

nucleocytoplasmic-transport-4r-tauopathies

DNAJC14 (DnaJ Heat Shock Protein Family Member C14) Protein

TOMM20 — Translocase of Outer Mitochondrial Membrane 20

KDM6A Gene

TOMM70

fancg