concept

SWI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SWI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

30Hypotheses

0Analyses

14Outgoing

37Incoming

8Experiments

0Debates

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💡 Concept Info

Name	SWI
Key Genes/Proteins	ADNP, ASC, ATG, BACE1, BECN1, BRG1
Related Diseases	autism spectrum disorder, cancer
Related Pathways	autophagy pathway
Linked Hypotheses	1 hypotheses

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

TDP-43 PET Ligand Development for Frontotemporal Dementia

gap · 1202 words

→

SIN3A Protein — SWI-Independent 3A Transcriptional Regulator

protein · 2130 words

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SMARCB1 — SWI/SNF Related Matrix Associated Actin Dependent Regulator of Chromatin Subfamily B Member 1

gene · 1352 words

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Pathway Diagram

graph TD
    SWI[SWI]
    SWI -->|activates| TNF[TNF]
    SWI -->|activates| TNFA[TNFA]
    SWI -->|activates| ULK1[ULK1]
    SWI -->|activates| cancer[cancer]
    SWI -->|causes| VHL[VHL]
    SWI -->|participates in| autophagy_pathway[autophagy pathway]
    SWI -->|participates in| oxidative_stress_response[oxidative stress response]
    SWI -->|participates in| necroptosis[necroptosis]
    SWI -->|participates in| MAPK_signaling[MAPK signaling]
    SNF[SNF] -->|interacts| SWI
    ASC[ASC] -->|activates| SWI
    BECN1[BECN1] -->|activates| SWI
    BRG1[BRG1] -->|activates| SWI
    CLDN2[CLDN2] -->|activates| SWI
    ERN1[ERN1] -->|activates| SWI
    IRGM1[IRGM1] -->|activates| SWI
    LC3[LC3] -->|activates| SWI
    MELK[MELK] -->|activates| SWI
    MTOR[MTOR] -->|activates| SWI

Outgoing (14)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:SWI	data_in	dataset_row	0.00
cancer	causes	disease	0.60
TNF	activates	gene	0.60
TNFA	activates	gene	0.60
ULK1	activates	gene	0.60
cancer	activates	disease	0.60
MAPK signaling	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
autism spectrum disorder	interacts_with	disease	0.60
VHL	causes	gene	0.60
autophagy pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.55

Incoming (37)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:SWI	data_in	dataset_row	0.00
SNF	interacts_with	gene	0.70
SNF	targets	gene	0.60
ROS	activates	gene	0.60
ADNP	interacts_with	gene	0.60
ATG	activates	gene	0.60
CCDC50	activates	gene	0.60
IKK	activates	gene	0.60
MAP1LC3	activates	gene	0.60
SNF	causes	gene	0.60
NLR	activates	gene	0.60
NRBF2	activates	gene	0.60
rapamycin	targets	drug	0.60
MAPK	activates	gene	0.60
ASC	activates	gene	0.60
BECN1	activates	gene	0.60
BRG1	activates	gene	0.60
CLDN2	activates	gene	0.60
ERN1	activates	gene	0.60
IRGM1	activates	gene	0.60
LC3	activates	gene	0.60
BACE1	associated_with	gene	0.60
PBRM1	causes	gene	0.60
MELK	activates	gene	0.60
MTOR	activates	gene	0.60
NLRP3	activates	gene	0.60
NOD2	activates	gene	0.60
PI3K	activates	gene	0.60
PYCARD	activates	gene	0.60
RALGAPA2	activates	gene	0.60
RIPK2	activates	gene	0.60
RIPK3	activates	gene	0.60
SMARCA4	activates	gene	0.60
SNF	activates	gene	0.60
SQSTM1	activates	gene	0.60
STAT3	activates	gene	0.60
RAPAMYCIN	associated_with	drug	0.45

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec	0.843	neurodegeneration	How do different microglial subtypes (DA
TREM2-Dependent Switch Hypothesis: TREM2 Agonism Redirects S	0.813	synaptic-biology	Does SPP1-mediated synaptic engulfment r
TREM2-APOE microglial state switching across AD, ALS, and PD	0.804	multi	Cross-disease neurodegeneration mechanis
HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA	0.766	neurodegeneration	What molecular mechanisms explain how ap
Tau/MAP6 ratio as a master switch for microtubule dynamics p	0.750	neurodegeneration	-

GBA1 Loss Triggers a TFEB-to-TFE3 Compensatory Switch in A9	0.750	neurodegeneration	-
Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in	0.735	alzheimers	TREM2 agonism vs antagonism in DAM micro
Metabolic Switch Targeting for A1→A2 Repolarization	0.726	neurodegeneration	Astrocyte reactivity subtypes in neurode
RAB29 Is the Critical Molecular Switch That Determines Wheth	0.710	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
TREM2 haploinsufficiency dysregulates microglial synaptic su	0.700	neurodegeneration	Synaptic pruning by microglia in neurode
Temporal Microglial State Switching	0.695	-	Neuroinflammation and microglial priming
Endothelial NRF2 Activation as a Master Switch for Post-CA B	0.689	neurodegeneration	Can ferroptosis inhibitors prevent BBB d
Lipid Droplet Dynamics as Phenotype Switches	0.666	neurodegeneration	Astrocyte reactivity subtypes in neurode
Complement C1q Subtype Switching	0.665	neurodegeneration	4R-tau strain-specific spreading pattern
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A	0.664	neurodegeneration	RNA binding protein dysregulation across
H7: Aberrant RNA Template Switching Converts Granules to Agg	0.625	neurodegeneration	How do pathological stress granules tran
Ketone-Based Metabolic Switching to Restore PV Interneuron F	0.609	neurodegeneration	test
Calmodulin isoform switching from CaMK to calcineurin activa	0.607	neurodegeneration	What determines the specificity of calci
Dynamic Microglial Phenotype Switching Biomarker Panel for N	0.577	neurodegeneration	What amyloid threshold level is required
REST Complex Dysregulation as Master Epigenetic Switch	0.570	neurodegeneration	Comparative epigenetic signatures: DNA m
Glucose-Ketone Metabolic Switch Timing	0.531	metabolic-neuroscience	What determines the optimal timing and d
Polycomb-to-Trithorax Switch at Synaptic Plasticity Genes	0.530	neurodegeneration	Comparative epigenetic signatures: DNA m
CD33-Dependent Switch Hypothesis: CD33 Antagonism Redirects	0.519	synaptic-biology	Does SPP1-mediated synaptic engulfment r
Conditional CRISPR Kill Switches for Aberrant Protein Cleara	0.496	neurodegeneration	CRISPR-based therapeutic approaches for
Membrane Lipid Composition-Dependent Specificity Switch Enab	0.455	neurodegeneration	Protein aggregation cross-seeding across
Calcineurin-FUNDC1 Axis as a Master Switch for Mitophagy vs.	0.430	neurodegeneration	What determines organelle-specific autop
Exposed amyloidogenic segments trigger CHIP-mediated oligome	0.380	protein-biochemistry	Do chaperones selectively recognize path
CK2-mediated HSP90α phosphorylation switches client discrimi	0.363	protein-biochemistry	Do chaperones selectively recognize path
Astroglial Gating of Microglial Ontogeny Switch	0.351	developmental-neurobiology	Do perinatal immune challenges create pe
Partial Agonist/SPP1 Splice Variant Strategy: Splice-Switchi	0.311	synaptic-biology	Does SPP1-mediated synaptic engulfment r

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (8)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
ABCA1 rs2230806 polymorphism association with dementia risk in hyperli	exploratory	dementia, Alzheimer's disease	0.900	0.00	human patients	proposed	N/A
Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State	in_vivo	neurodegeneration	0.774	0.65	C57BL/6J LPS model (chronic i.	proposed	$58,000
Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an	falsification	Neurodegeneration	0.400	0.50	cell_line	completed	$100,000
Proposed experiment from debate on Microglia activate astrocytes via I	falsification	Neuroinflammation	0.400	0.50	cell_line	completed	$80,000
Metabolic Pathway-Targeted Therapy in ALS	clinical	ALS	0.400	0.50	human	proposed	$6,550,000
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
GLP-1 Agonist Responder Prediction Study — Precision Medicine for Neur	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Metabolic Syndrome-Parkinson's Disease Axis Clinical Trial	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Meta [PMID:41387352]	Pesce NA, Seminara G, Giarrusso G, Tomas	Adv Biol (Weinh)	2026	1
Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative [PMID:39987285]	Fang M, Zhou Y, He K, Lu Y, Tao F, Huang	Mol Neurobiol	2025	1
Hexokinase 2-mediated metabolic stress and inflammation burden of liver macropha [PMID:40014451]	Li J, Chen X, Song S, Jiang W, Geng T, W	Cell Rep	2025	1
The PI3K/Akt Pathway and Glucose Metabolism: A Dangerous Liaison in Cancer. [PMID:38904014]	Fontana F, Giannitti G, Marchesi S, Limo	Int J Biol Sci	2024	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
Metabolic phenotype of bladder cancer. [PMID:26975021]	Massari F, Ciccarese C, Santoni M, Iacov	Cancer Treat Rev	2016	1
Neuroprotective Effects of Berberine Chloride Against the Aluminium Chloride-Ind [PMID:40014257]	Uvarajan D, Gnanarajan R, Karuppusamy PA	Mol Biotechnol	2026	0
Aryl hydrocarbon receptor impairs HK2-controlled flux of the hexosamine biosynth [PMID:40582563]	Li S, Zhu J, Song J, Yang L, Gong Y et a	J Adv Res	2026	0
Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010]	Albrechtsen HM, Saritas G, Winge SB, Mai	J Clin Endocrinol Metab	2026	0
HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis [PMID:41023273]	Mitchell CD, Morris CA, Wild M, Cunningh	Acta Pharmacol Sin	2026	0
Hypoxia-Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via t [PMID:41229334]	Zhu XH, Hou JW, Lv ZY, Sun MH, Zhang XY	Kaohsiung J Med Sci	2026	0
Epigenetics in chronic rhinosinusitis. [PMID:41442742]	Kumar N, Brar T, Lal D	Curr Opin Otolaryngol Head Nec	2026	0
Granzyme B knockdown inhibits NLRP3-mediated pyroptosis and the JAK2/STAT3 signa [PMID:41447776]	Wang M, Chen D, Zhang D, Han H, Xie M et	Tissue Cell	2026	0
Multimodal Antiatherosclerotic Effects of Clinical-Grade Mesenchymal Stem Cell-D [PMID:41503702]	Kim J, Park D, Yoo J, Kim JE, Kim EH et	Stroke	2026	0
Targeting glycolysis in prostate cancer: Molecular mechanisms and therapeutic ad [PMID:41548699]	Zhang J, Zhang T, Song D, Xu D	Biochim Biophys Acta Rev Cance	2026	0
Interplay between cholesterol, Bis(monoacylglycerol)phosphate, and parasitophoro [PMID:41747887]	Hennot C, Leroux M, Lambert R, Boukherro	Biochimie	2026	0
Integrated Bioinformatics Analysis of a TF-miRNA-mRNA Regulatory Network in Reti [PMID:41755728]	Liang C, Xie H, Shi Q, Diao Y, Yu G et a	Curr Eye Res	2026	0
Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286]	Jackson G, Islam H, de Souza Teixeira AA	Life Sci	2026	0
ApoE4 Drives Microglial Lipid Dysregulation in Alzheimer's Disease via Epigeneti [PMID:41808104]	Lin L, Pan Z, Wei Z, Jiang X, Lai Y et a	J Neuroinflammation	2026	0
Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzhei [PMID:41844011]	Wu L, Dong YT, Mu X, Luo X, Chen ZJ	J Prev Alzheimers Dis	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SWI in their description or question text

Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in Amyloid Phase, Anta

Score: 0.735 · alzheimers · 2026-04-04

## Mechanistic Overview Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in Amyloid Phase, Antagonist in Tau Ph

Metabolic Switch Targeting for A1→A2 Repolarization

Score: 0.726 · neurodegeneration · 2026-04-02

## Mechanistic Overview Metabolic Switch Targeting for A1→A2 Repolarization starts from the claim that modulating HK2 wi

RAB29 Is the Critical Molecular Switch That Determines Whether LRRK2 Signal Ampl

Score: 0.710 · neurodegeneration · 2026-04-26

RAB29 functions as a gatekeeper—when lysosomes swell, RAB29-GTP increases, recruits LRRK2, and G2019S hyperphosphorylate

TREM2 haploinsufficiency dysregulates microglial synaptic surveillance, switchin

Score: 0.700 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The triggering receptor expressed on myeloid cells 2 (TREM2) functions as a criti

Temporal Microglial State Switching

Score: 0.695 · unknown disease · 2026-04-04

## Mechanistic Overview Temporal Microglial State Switching starts from the claim that modulating Optogenetic constructs

Endothelial NRF2 Activation as a Master Switch for Post-CA BBB Protection

Score: 0.689 · neurodegeneration · 2026-04-17

## Mechanistic Overview Endothelial NRF2 Activation as a Master Switch for Post-CA BBB Protection starts from the claim

Lipid Droplet Dynamics as Phenotype Switches

Score: 0.666 · neurodegeneration · 2026-04-02

## Mechanistic Overview Lipid Droplet Dynamics as Phenotype Switches starts from the claim that modulating DGAT1 and SOA

Complement C1q Subtype Switching

Score: 0.665 · neurodegeneration · 2026-04-02

## Mechanistic Overview Complement C1q Subtype Switching starts from the claim that modulating C1QA within the disease c

Stathmin-2 Splice Switching to Prevent Axonal Degeneration Across the ALS-FTD-AD

Score: 0.664 · neurodegeneration · 2026-04-13

**Molecular Mechanism and Rationale** The stathmin-2 splice switching therapeutic approach targets a fundamental pathom

H7: Aberrant RNA Template Switching Converts Granules to Aggregation Prone

Score: 0.625 · neurodegeneration · 2026-04-22

## Mechanistic Overview H7: Aberrant RNA Template Switching Converts Granules to Aggregation Prone starts from the claim

Ketone-Based Metabolic Switching to Restore PV Interneuron Function

Score: 0.609 · neurodegeneration · 2026-04-16

## Mechanistic Overview Ketone-Based Metabolic Switching to Restore PV Interneuron Function starts from the claim that m

Calmodulin isoform switching from CaMK to calcineurin activation upon lysosomal

Score: 0.607 · neurodegeneration · 2026-04-21

## Mechanistic Overview Calmodulin isoform switching from CaMK to calcineurin activation upon lysosomal permeabilization

Dynamic Microglial Phenotype Switching Biomarker Panel for Neuroinflammatory Tre

Score: 0.577 · neurodegeneration · 2026-04-20

**Molecular Mechanism and Rationale** The molecular foundation of this biomarker panel centers on the intricate interpl

REST Complex Dysregulation as Master Epigenetic Switch

Score: 0.570 · neurodegeneration · 2026-04-25

REST Complex Dysregulation as Master Epigenetic Switch: The RE1-silencing transcription factor (REST) has been proposed