gene

PRKCI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKCI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections
0Hypotheses
0Analyses
16Outgoing
8Incoming

Summary

Page for PRKCI

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🧬 Gene Info
Gene SymbolPRKCI
Chromosome3q26.2
Protein TypeKinase
Functionencodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases.
Subcellular LocalizationPRKCI localizes to multiple cellular compartments:
PathwaysOxidative Stress, Apoptosis, Akt, Ferroptosis, Dna Methylation
Ensembl IDENSG00000163558
GeneCardsPRKCI
Human Protein AtlasPRKCI
Associated Diseasesneurodegeneration
InteractionsAKT, ALZHEIMER, NEURON, ALZHEIMER'S DISEASE, AND
KG Connections24 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

PRKCI

gene · 2128 words

pard3

gene · 2705 words

Protein Kinase C Signaling Pathway

mechanism · 2074 words

Protein Kinase C (PKC) Signaling in Parkinson's Disease

mechanism · 1953 words

PRKCZ

gene · 999 words

Genes

index · 271 words

Pathway Diagram

graph TD
    PRKCI["PRKCI"]
    Alzheimer{"Alzheimer"}
    PRKCI -->|"activates"| Alzheimer
    ALZHEIMER["ALZHEIMER"]
    PRKCI -->|"activates"| ALZHEIMER
    AMYLOID["AMYLOID"]
    PRKCI -->|"therapeutic_target"| AMYLOID
    FERROPTOSIS["FERROPTOSIS"]
    PRKCI -->|"therapeutic_target"| FERROPTOSIS
    AKT["AKT"]
    PRKCI -->|"activates"| AKT
    NEURON["NEURON"]
    PRKCI -->|"activates"| NEURON
    Oxidative_Stress(["Oxidative Stress"])
    PRKCI -->|"therapeutic_target"| Oxidative_Stress
    Apoptosis(["Apoptosis"])
    PRKCI -->|"therapeutic_target"| Apoptosis
    Akt(["Akt"])
    PRKCI -->|"activates"| Akt
    Ferroptosis(["Ferroptosis"])
    PRKCI -->|"therapeutic_target"| Ferroptosis
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| PRKCI
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"therapeutic_target"| PRKCI
    AND["AND"]
    AND -->|"activates"| PRKCI
    APP_PS1["APP/PS1"]
    APP_PS1 -->|"therapeutic_target"| PRKCI
    APP["APP"]
    APP -->|"therapeutic_target"| PRKCI

Outgoing (16)

TargetRelationTypeStr
Alzheimeractivatesdisease0.65
AKTactivatesgene0.60
VDAC1therapeutic_targetgene0.60
IL16therapeutic_targetgene0.60
ALZHEIMERactivatesgene0.60

Incoming (8)

SourceRelationTypeStr
APPtherapeutic_targetgene0.60
SORL1therapeutic_targetgene0.60
ALZHEIMER'S DISEASEactivatesgene0.60
APOPTOSIStherapeutic_targetgene0.60
ANDactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found