Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PRKCI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PRKCI |
| Chromosome | 3q26.2 |
| Protein Type | Kinase |
| Function | encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. |
| Subcellular Localization | PRKCI localizes to multiple cellular compartments: |
| Pathways | Oxidative Stress, Apoptosis, Akt, Ferroptosis, Dna Methylation |
| Ensembl ID | ENSG00000163558 |
| GeneCards | PRKCI |
| Human Protein Atlas | PRKCI |
| Associated Diseases | neurodegeneration |
| Interactions | AKT, ALZHEIMER, NEURON, ALZHEIMER'S DISEASE, AND |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PRKCI["PRKCI"]
Alzheimer{"Alzheimer"}
PRKCI -->|"activates"| Alzheimer
ALZHEIMER["ALZHEIMER"]
PRKCI -->|"activates"| ALZHEIMER
AMYLOID["AMYLOID"]
PRKCI -->|"therapeutic_target"| AMYLOID
FERROPTOSIS["FERROPTOSIS"]
PRKCI -->|"therapeutic_target"| FERROPTOSIS
AKT["AKT"]
PRKCI -->|"activates"| AKT
NEURON["NEURON"]
PRKCI -->|"activates"| NEURON
Oxidative_Stress(["Oxidative Stress"])
PRKCI -->|"therapeutic_target"| Oxidative_Stress
Apoptosis(["Apoptosis"])
PRKCI -->|"therapeutic_target"| Apoptosis
Akt(["Akt"])
PRKCI -->|"activates"| Akt
Ferroptosis(["Ferroptosis"])
PRKCI -->|"therapeutic_target"| Ferroptosis
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"activates"| PRKCI
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"therapeutic_target"| PRKCI
AND["AND"]
AND -->|"activates"| PRKCI
APP_PS1["APP/PS1"]
APP_PS1 -->|"therapeutic_target"| PRKCI
APP["APP"]
APP -->|"therapeutic_target"| PRKCI| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | activates | disease | 0.65 |
| AKT | activates | gene | 0.60 |
| VDAC1 | therapeutic_target | gene | 0.60 |
| IL16 | therapeutic_target | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| AMYLOID | therapeutic_target | gene | 0.60 |
| FERROPTOSIS | therapeutic_target | gene | 0.60 |
| NEURON | activates | gene | 0.60 |
| Oxidative Stress | therapeutic_target | pathway | 0.60 |
| Apoptosis | therapeutic_target | pathway | 0.60 |
| Akt | activates | pathway | 0.60 |
| Ferroptosis | therapeutic_target | pathway | 0.60 |
| DEPRESSION | therapeutic_target | gene | 0.60 |
| Dna Methylation | therapeutic_target | pathway | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APP | therapeutic_target | gene | 0.60 |
| SORL1 | therapeutic_target | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| AND | activates | gene | 0.60 |
| APP/PS1 | therapeutic_target | gene | 0.60 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.60 |
| DNA | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||