Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IL16 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, expressed in. Associated with Als, Autism, Inflammation. Connected to 23 entities in the SciDEX knowledge graph.
| Gene Symbol | IL16 |
| Chromosome | 15q22.3 |
| Function | IL-16 has diverse biological functions: |
| Primary Expression | neurons, astrocytes, and microglia, where it modulates inflamm |
| Molecular Weight | ~14 kDa (mature form) |
| Amino Acids | 631 aa |
| Pathways | MAPK, PI3K, NF-κB |
| NCBI Gene ID | 3603 |
| GeneCards | IL16 |
| Human Protein Atlas | IL16 |
| Protein Class | Cytokine |
| Cell Type | Expression Level |
| Neurons | Moderate |
| Astrocytes | High |
| Microglia | High |
| Associated Diseases | Als, Inflammation, Ms, Traumatic Brain Injury |
| KG Connections | 49 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
IL16["<b>IL16</b>"]
Autism{"Autism"}
IL16 -->|"expressed in"| Autism
Inflammation{"Inflammation"}
IL16 -->|"associated with"| Inflammation
Traumatic_Brain_Injury{"Traumatic Brain Injury"}
IL16 -->|"associated with"| Traumatic_Brain_Injury
Als{"Als"}
IL16 -->|"associated with"| Als
Ms{"Ms"}
IL16 -->|"associated with"| Ms
Dna_Methylation(["Dna Methylation"])
IL16 -->|"expressed in"| Dna_Methylation
GFAP["GFAP"]
IL16 -->|"biomarker for"| GFAP
Autophagy(["Autophagy"])
IL16 -->|"biomarker for"| Autophagy
neurodegeneration["neurodegeneration"]
IL16 -->|"implicated in"| neurodegeneration
GENES["GENES"]
GENES -->|"expressed in"| IL16
DNA["DNA"]
DNA -->|"expressed in"| IL16
CALCOCO2["CALCOCO2"]
CALCOCO2 -->|"expressed in"| IL16
FMN2["FMN2"]
FMN2 -->|"expressed in"| IL16
MDH1["MDH1"]
MDH1 -->|"associated with"| IL16
S100B["S100B"]
S100B -->|"biomarker for"| IL16
PSEN1["PSEN1"]
PSEN1 -->|"biomarker for"| IL16
GFAP -->|"biomarker for"| IL16
AMYLOID_BETA["AMYLOID-BETA"]
AMYLOID_BETA -->|"biomarker for"| IL16
CYTOKINES["CYTOKINES"]
CYTOKINES -->|"biomarker for"| IL16
INFLAMMATION["INFLAMMATION"]
INFLAMMATION -->|"associated with"| IL16
TAU["TAU"]
TAU -->|"associated with"| IL16
style IL16 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Autism | expressed_in | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Traumatic Brain Injury | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Depression | therapeutic_target | disease | 0.65 |
| GFAP | biomarker_for | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| MDH1 | associated_with | gene | 0.60 |
| IL1B | associated_with | gene | 0.60 |
| Dna Methylation | expressed_in | pathway | 0.60 |
| Autophagy | biomarker_for | pathway | 0.60 |
| AND | associated_with | gene | 0.60 |
| AMYLOID-BETA | biomarker_for | gene | 0.60 |
| CYTOKINES | biomarker_for | gene | 0.60 |
| CCL2 | biomarker_for | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| AUTOPHAGY | biomarker_for | gene | 0.60 |
| Amyloid | biomarker_for | pathway | 0.60 |
| Dna Methylation | therapeutic_target | pathway | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AΒ1-42 | alters | compound | 0.80 |
| SNCA | alters | gene | 0.80 |
| CALCOCO2 | expressed_in | gene | 0.60 |
| FMN2 | expressed_in | gene | 0.60 |
| MDH1 | associated_with | gene | 0.60 |
| S100B | biomarker_for | gene | 0.60 |
| PSEN1 | biomarker_for | gene | 0.60 |
| GFAP | biomarker_for | gene | 0.60 |
| TAU | associated_with | gene | 0.60 |
| SORL1 | therapeutic_target | gene | 0.60 |
| PRKCI | therapeutic_target | gene | 0.60 |
| VDAC1 | therapeutic_target | gene | 0.60 |
| CCL5 | associated_with | gene | 0.60 |
| CSF2 | associated_with | gene | 0.60 |
| CXCL10 | associated_with | gene | 0.60 |
| CXCL8 | associated_with | gene | 0.60 |
| ICAM1 | associated_with | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| DNA | expressed_in | gene | 0.60 |
| AMYLOID-BETA | biomarker_for | gene | 0.60 |
| CYTOKINES | biomarker_for | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| AUTOPHAGY | biomarker_for | gene | 0.60 |
| BRAIN INJURY | associated_with | gene | 0.60 |
| AMYLOID | biomarker_for | gene | 0.60 |
| DNA | therapeutic_target | gene | 0.60 |
| DEPRESSION | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||