gene

IL16

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL16: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections
0Hypotheses
0Analyses
22Outgoing
27Incoming

Summary

IL16 is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, expressed in. Associated with Als, Autism, Inflammation. Connected to 23 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolIL16
Chromosome15q22.3
FunctionIL-16 has diverse biological functions:
Primary Expressionneurons, astrocytes, and microglia, where it modulates inflamm
Molecular Weight~14 kDa (mature form)
Amino Acids631 aa
PathwaysMAPK, PI3K, NF-κB
NCBI Gene ID3603
GeneCardsIL16
Human Protein AtlasIL16
Protein ClassCytokine
Cell TypeExpression Level
NeuronsModerate
AstrocytesHigh
MicrogliaHigh
Associated DiseasesAls, Inflammation, Ms, Traumatic Brain Injury
KG Connections49 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

IL16 Gene

gene · 611 words

PRKCI

gene · 2128 words

FMN2 Gene

gene · 904 words

Genes

index · 271 words

Pathway Diagram

graph TD
    IL16["<b>IL16</b>"]
    Autism{"Autism"}
    IL16 -->|"expressed in"| Autism
    Inflammation{"Inflammation"}
    IL16 -->|"associated with"| Inflammation
    Traumatic_Brain_Injury{"Traumatic Brain Injury"}
    IL16 -->|"associated with"| Traumatic_Brain_Injury
    Als{"Als"}
    IL16 -->|"associated with"| Als
    Ms{"Ms"}
    IL16 -->|"associated with"| Ms
    Dna_Methylation(["Dna Methylation"])
    IL16 -->|"expressed in"| Dna_Methylation
    GFAP["GFAP"]
    IL16 -->|"biomarker for"| GFAP
    Autophagy(["Autophagy"])
    IL16 -->|"biomarker for"| Autophagy
    neurodegeneration["neurodegeneration"]
    IL16 -->|"implicated in"| neurodegeneration
    GENES["GENES"]
    GENES -->|"expressed in"| IL16
    DNA["DNA"]
    DNA -->|"expressed in"| IL16
    CALCOCO2["CALCOCO2"]
    CALCOCO2 -->|"expressed in"| IL16
    FMN2["FMN2"]
    FMN2 -->|"expressed in"| IL16
    MDH1["MDH1"]
    MDH1 -->|"associated with"| IL16
    S100B["S100B"]
    S100B -->|"biomarker for"| IL16
    PSEN1["PSEN1"]
    PSEN1 -->|"biomarker for"| IL16
    GFAP -->|"biomarker for"| IL16
    AMYLOID_BETA["AMYLOID-BETA"]
    AMYLOID_BETA -->|"biomarker for"| IL16
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"biomarker for"| IL16
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"associated with"| IL16
    TAU["TAU"]
    TAU -->|"associated with"| IL16
    style IL16 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

TargetRelationTypeStr
Autismexpressed_indisease0.65
Inflammationassociated_withdisease0.65
Traumatic Brain Injuryassociated_withdisease0.65
Alsassociated_withdisease0.65
Msassociated_withdisease0.65

Incoming (27)

SourceRelationTypeStr
AΒ1-42alterscompound0.80
SNCAaltersgene0.80
CALCOCO2expressed_ingene0.60
FMN2expressed_ingene0.60
MDH1associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found