concept

PTP1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTP1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

36Outgoing

12Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PTP1B
Key Genes/Proteins	JNK1, AMPK, OXIDATIVE STRESS
Related Diseases	Metabolic Syndrome, Neuroinflammation, ALS, Inflammation, Als

Wiki Pages (14)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PTP1B["PTP1B"]
    PTP1B -.protects against.-> Metabolic_Syndrome["Metabolic Syndrome"]
    PTP1B -->|"inhibits"| JNK1["JNK1"]
    PTP1B -.protects against.-> Neuroinflammation["Neuroinflammation"]
    PTP1B -->|"activates"| ALS["ALS"]
    PTP1B -->|"activates"| Inflammation["Inflammation"]
    PTP1B -->|"target for"| Als["Als"]
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -.protects against.-> PTP1B
    INFLAMMATION["INFLAMMATION"] -->|"activates"| PTP1B
    AMPK["AMPK"] -->|"target for"| PTP1B
    JNK["JNK"] -->|"activates"| PTP1B
    ATP["ATP"] -->|"target for"| PTP1B
    GAIN["GAIN"] -->|"activates"| PTP1B
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| PTP1B

Outgoing (36)

Target	Relation	Type	Str
Metabolic Syndrome	protects_against	disease	0.80
JNK1	inhibits	gene	0.80
Neuroinflammation	protects_against	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
Metabolic Syndrome	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Obesity	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
AMPK	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ATP	activates	gene	0.60
GAIN	activates	gene	0.60
AND	activates	gene	0.60
JNK	activates	gene	0.60
ACC	associated_with	gene	0.60
Oxidative Stress	activates	pathway	0.60
ATP	therapeutic_target	gene	0.60
ALZHEIMER	activates	gene	0.60
BDNF	expressed_in	gene	0.60
Leptin	expressed_in	protein	0.60
Actin	activates	protein	0.60
Bdnf	expressed_in	protein	0.60
Rb	therapeutic_target	protein	0.60
Ras	associated_with	protein	0.60
oxidative stress response	participates_in	pathway	0.60
MAPK signaling	participates_in	pathway	0.60
neuroinflammation	protects_against	disease	0.60
thalamus	expressed_in	brain_region	0.60
diabetes	interacts_with	disease	0.60
Thalamus	expressed_in	brain_region	0.55
Hypothalamus	expressed_in	brain_region	0.55

Incoming (12)

Source	Relation	Type	Str
NEUROINFLAMMATION	protects_against	gene	0.60
INFLAMMATION	activates	gene	0.60
AMPK	therapeutic_target	gene	0.60
JNK	activates	gene	0.60
ATP	therapeutic_target	gene	0.60
GAIN	activates	gene	0.60
ATP	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ACC	associated_with	gene	0.60
JNK1	inhibits	gene	0.60
AMPK	activates	gene	0.60
PKM2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PTP1B

Understanding Entity Pages

Wiki Pages (14)

JAK-STAT Signaling Pathway in Neurodegeneration

EPHA3 Gene

Intercellular Adhesion Molecule-5 Protein

SYK Kinase in Microglial Activation and Alzheimer's Disease

Leptin Signaling Pathway in Neurodegeneration

EPHA5 Gene

SRC Protein (SRC Proto-Oncogene)

STAT4 Gene

epha2

ptprb-protein

JAK2 Gene - Janus Kinase 2

ptp1b-protein