JNK1

Understanding Entity Pages

This page aggregates everything SciDEX knows about JNK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

JNK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Als, Alzheimer. Connected to 65 entities in the SciDEX knowledge graph.

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graph TD
    JNK1["<b>JNK1</b>"]
    Als{"Als"}
    JNK1 -->|"activates"| Als
    Neurodegeneration{"Neurodegeneration"}
    JNK1 -->|"activates"| Neurodegeneration
    Neuroinflammation{"Neuroinflammation"}
    JNK1 -->|"activates"| Neuroinflammation
    Multiple_Sclerosis{"Multiple Sclerosis"}
    JNK1 -->|"activates"| Multiple_Sclerosis
    Ms{"Ms"}
    JNK1 -->|"activates"| Ms
    Inflammation{"Inflammation"}
    JNK1 -->|"activates"| Inflammation
    Alzheimer{"Alzheimer"}
    JNK1 -->|"activates"| Alzheimer
    Fibrosis{"Fibrosis"}
    JNK1 -->|"activates"| Fibrosis
    Anxiety{"Anxiety"}
    JNK1 -->|"activates"| Anxiety
    Depression{"Depression"}
    JNK1 -->|"activates"| Depression
    ALS{"ALS"}
    JNK1 -->|"activates"| ALS
    JNK2["JNK2"]
    JNK1 -->|"activates"| JNK2
    JUN["JUN"]
    JUN -->|"activates"| JNK1
    BIP["BIP"]
    BIP -->|"activates"| JNK1
    P38["P38"]
    P38 -->|"activates"| JNK1
    JNK2 -->|"activates"| JNK1
    C_JUN["C-JUN"]
    C_JUN -->|"activates"| JNK1
    CXCL1["CXCL1"]
    CXCL1 -->|"activates"| JNK1
    GFAP["GFAP"]
    GFAP -->|"activates"| JNK1
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"activates"| JNK1
    TNF["TNF"]
    TNF -->|"activates"| JNK1
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"activates"| JNK1
    IL_6["IL-6"]
    IL_6 -->|"activates"| JNK1
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"activates"| JNK1
    style JNK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0