concept

GHRL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GHRL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

91Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GHRL
Key Genes/Proteins	FNDC5, INFLAMMATION, TGM2, FGF21, IL-6, APP
Related Diseases	Aging, Fibrosis, ALS, Inflammation, Senescence

Wiki Pages (2)

Knowledge base pages for this entity

Ghrelin Signaling Pathway in Neurodegeneration

mechanism · 1627 words

→

Ghrelin Neurons

cell · 961 words

→

Pathway Diagram

graph TD
    GHRL["GHRL"]
    GHRL -.biomarker for.-> Aging["Aging"]
    GHRL -.biomarker for.-> Fibrosis["Fibrosis"]
    GHRL -->|"activates"| ALS["ALS"]
    GHRL -.biomarker for.-> Inflammation["Inflammation"]
    GHRL -.biomarker for.-> Senescence["Senescence"]
    GHRL -->|"activates"| Als["Als"]
    GHRL -->|"interacts"| Ptsd["Ptsd"]
    GHRL -.biomarker for.-> FNDC5["FNDC5"]
    HRH2["HRH2"] -->|"upregulates"| GHRL
    CX3CL1["CX3CL1"] -.biomarker for.-> GHRL
    APOPTOSIS["APOPTOSIS"] -.biomarker for.-> GHRL
    VIM["VIM"] -.biomarker for.-> GHRL
    AGING["AGING"] -.biomarker for.-> GHRL
    C1Q["C1Q"] -->|"activates"| GHRL
    S100B["S100B"] -->|"activates"| GHRL
    PROGRANULIN["PROGRANULIN"] -.biomarker for.-> GHRL

Outgoing (59)

Target	Relation	Type	Str
Aging	biomarker_for	disease	0.65
Fibrosis	biomarker_for	disease	0.65
ALS	activates	disease	0.65
Inflammation	biomarker_for	disease	0.65
Senescence	biomarker_for	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Ptsd	interacts_with	disease	0.65
FNDC5	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
TGM2	activates	gene	0.60
FGF21	biomarker_for	gene	0.60
IL-6	biomarker_for	gene	0.60
APP	activates	gene	0.60
HMGB1	activates	gene	0.60
CXCL10	biomarker_for	gene	0.60
VIMENTIN	biomarker_for	gene	0.60
Complement	activates	pathway	0.60
Amyloid	activates	pathway	0.60
Apoptosis	biomarker_for	pathway	0.60
PGRN	biomarker_for	gene	0.60
PLAU	biomarker_for	gene	0.60
S100B	activates	gene	0.60
PROGRANULIN	biomarker_for	gene	0.60
AMYLOID	activates	gene	0.60
BDNF	biomarker_for	gene	0.60
IGF-1	activates	gene	0.60
FGF23	biomarker_for	gene	0.60
AGING	biomarker_for	gene	0.60
Fibroblast	biomarker_for	cell_type	0.60
Neuron	biomarker_for	cell_type	0.60
HCRTR1	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
AND	activates	gene	0.60
GENES	biomarker_for	gene	0.60
C1Q	activates	gene	0.60
GPNMB	activates	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
Chemokine	biomarker_for	protein	0.60
Bdnf	biomarker_for	protein	0.60
Ghrelin	activates	protein	0.60
Leptin	biomarker_for	protein	0.60
Adiponectin	activates	protein	0.60
Interleukin	activates	protein	0.60
Amyloid Beta	activates	protein	0.60
Fibronectin	biomarker_for	protein	0.60
Insulin	activates	protein	0.60
HCRTR2	associated_with	gene	0.60
Ghrelin	associated_with	protein	0.60

Incoming (32)

Source	Relation	Type	Str
CX3CL1	biomarker_for	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
VIM	biomarker_for	gene	0.60
AGING	biomarker_for	gene	0.60
C1Q	activates	gene	0.60
S100B	activates	gene	0.60
PROGRANULIN	biomarker_for	gene	0.60
AMYLOID	activates	gene	0.60
FGF23	biomarker_for	gene	0.60
PLAU	biomarker_for	gene	0.60
BDNF	biomarker_for	gene	0.60
COMPLEMENT	activates	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
GPNMB	activates	gene	0.60
GENES	biomarker_for	gene	0.60
IGF-1	activates	gene	0.60
FGF21	biomarker_for	gene	0.60
VIMENTIN	biomarker_for	gene	0.60
HMGB1	activates	gene	0.60
FNDC5	biomarker_for	gene	0.60
IL-6	biomarker_for	gene	0.60
CXCL10	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
APP	activates	gene	0.60
PGRN	biomarker_for	gene	0.60
AND	activates	gene	0.60
HCRTR2	associated_with	gene	0.60
GENES	associated_with	gene	0.60
HCRTR1	interacts_with	gene	0.60
TGM2	activates	gene	0.60
C3	activates	gene	0.60
ADIPOQ	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found