gene

NOS3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

381Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

NOS3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, associated with. Associated with Hepatitis, Ischemia, Ms. Connected to 122 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NOS3
Full Name	Endothelial Nitric Oxide Synthase (NOS3)
Aliases	Nitric Oxide Synthase 3
Chromosome	7q36
Protein Type	Protein
Function	This is the basis for the therapeutic use of nitrates in cardiovascular disease [@katusic2009].
Primary Expression	vascular endothelial cells where it catalyzes the production of nitric oxide (NO) from L-arginine
Amino Acids	490 aa
Pathways	Mapk, autophagy pathway, complement cascade, phagocytosis
UniProt ID	Search UniProt
GeneCards	NOS3
Human Protein Atlas	NOS3
Associated Diseases	ALS, Alzheimer, Cancer, podocyte foot process effacement
Known Drugs/Compounds	rapamycin
Interactions	ACOX1, ADAMTS1, Adiponectin, ADIPOQ, AMPK, ATG
KG Connections	381 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NOS3 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

Endothelial Nitric Oxide Synthase (NOS3)

protein · 1631 words

→

NOS3 — Nitric Oxide Synthase 3

gene · 603 words

→

Pathway Diagram

flowchart TD
    NOS3["NOS3
(Endothelial NOS)"]
    NO["Nitric Oxide
Production"]
    SIRT1["SIRT1
(Sirtuin 1)"]
    NFE2L2["NFE2L2
(Nrf2)"]
    MTOR["MTOR
(mTOR Complex)"]
    BECN1["BECN1
(Beclin-1)"]
    FOXO1["FOXO1
(FoxO1)"]
    MAP3K5["MAP3K5
(ASK1)"]
    STING1["STING1
(STING)"]
    
    Stroke["Stroke
Protection"]
    Ischemia["Ischemic
Injury"]
    MS["Multiple
Sclerosis"]
    Autophagy["Autophagy
Regulation"]
    Oxidative["Oxidative
Stress"]
    Inflammation["Neuroinflammation"]
    Apoptosis["Cell Death
Pathways"]
    Neuroprotection["Neuroprotection"]

    NOS3 -->|"produces"| NO
    NO -->|"activates"| SIRT1
    NO -->|"activates"| NFE2L2
    SIRT1 -->|"enhances"| NFE2L2
    NFE2L2 -->|"reduces"| Oxidative
    
    NOS3 -->|"inhibits"| MTOR
    MTOR -->|"inhibits"| BECN1
    BECN1 -->|"promotes"| Autophagy
    SIRT1 -->|"activates"| FOXO1
    FOXO1 -->|"promotes"| Autophagy
    
    NOS3 -->|"inhibits"| MAP3K5
    MAP3K5 -->|"promotes"| Apoptosis
    NOS3 -->|"modulates"| STING1
    STING1 -->|"promotes"| Inflammation
    
    NO -->|"protects_against"| Stroke
    NO -->|"reduces"| Ischemia
    NOS3 -->|"therapeutic_for"| MS
    Autophagy -->|"promotes"| Neuroprotection
    NFE2L2 -->|"promotes"| Neuroprotection

    style NOS3 fill:#006494
    style SIRT1 fill:#1b5e20
    style NFE2L2 fill:#1b5e20
    style BECN1 fill:#4a1a6b
    style FOXO1 fill:#4a1a6b
    style MAP3K5 fill:#ef5350
    style STING1 fill:#ef5350
    style Stroke fill:#5d4400
    style Ischemia fill:#ef5350
    style MS fill:#ef5350
    style Neuroprotection fill:#1b5e20
    style Oxidative fill:#ef5350
    style Inflammation fill:#ef5350
    style Apoptosis fill:#ef5350

Outgoing (204)

Target	Relation	Type	Str
Idiopathic Nephrotic Syndrome	biomarker_for	disease	0.85
podocyte foot process effacement	associated_with	phenotype	0.75
nitric oxide	regulates	biomarker	0.70
MAPK signaling	participates_in	pathway	0.70
Stroke	therapeutic_target	disease	0.65
Ischemia	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Hepatitis	interacts_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Alzheimer	protects_against	disease	0.65
Cancer	protects_against	disease	0.65
Aging	protects_against	disease	0.65
ALS	protects_against	disease	0.65
Tumor	interacts_with	disease	0.65
ALS	expressed_in	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
NEURON	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
Pi3K	therapeutic_target	pathway	0.60
Akt	therapeutic_target	pathway	0.60
complement cascade	participates_in	pathway	0.60
phagocytosis	activates	process	0.60
TLR4	regulates	gene	0.60
SLC16A1	associated_with	gene	0.60
RAS	activates	gene	0.60
RUBCNL	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
TNF	regulates	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
STROKE	therapeutic_target	gene	0.60
SREBF1	activates	entity	0.60
SREBF2	activates	entity	0.60
STING1	activates	entity	0.60
STX17	activates	entity	0.60
ESR2	therapeutic_target	gene	0.60
DRD2	therapeutic_target	gene	0.60
AKT1	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
ESR1	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60

Incoming (177)

Source	Relation	Type	Str
Paeoniflorin	upregulates	compound	0.88
Idiopathic Nephrotic Syndrome sera	upregulates	compound	0.75
vascular shear stress	activates	process	0.70
NOS2	therapeutic_target	gene	0.60
AKT1	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
MMP9	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
HMOX1	therapeutic_target	gene	0.60
MAPK14	therapeutic_target	gene	0.60
RELA	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
RB1	associated_with	gene	0.60
GAA	associated_with	gene	0.60
TNF	therapeutic_target	gene	0.60
DRD2	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60
HIF	associated_with	gene	0.60
ACOX1	activates	gene	0.60
ATG	activates	gene	0.60
CREB	activates	gene	0.60
GAA	targets	gene	0.60
RB1	therapeutic_target	gene	0.60
LC3	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
MMP3	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
PPARG	therapeutic_target	gene	0.60
MAOA	therapeutic_target	gene	0.60
PRKCA	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
ARG1	therapeutic_target	gene	0.60
IL6	associated_with	gene	0.60
ESR2	associated_with	gene	0.60
NOS2	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
CCL2	regulates	gene	0.60
INS	biomarker_for	gene	0.60
ANXA5	regulates	gene	0.60
SLC16A1	therapeutic_target	gene	0.60
APP	targets	gene	0.60
CXCL8	targets	gene	0.60
HDAC1	targets	gene	0.60
MAPK8	targets	gene	0.60
ADAMTS1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

endocrinology | 2026-04-13 | 2 hypotheses Top: 0.653

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Despite FDA warnings and a 315% increased erythrocytosis risk with TRT, the asso

closed · Rounds: 4 · Score: 0.83 · 2026-04-14

Related Research

Hypotheses and analyses mentioning NOS3 in their description or question text

No additional research found