NOS3

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOS3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

NOS3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, associated with. Associated with Hepatitis, Ischemia, Ms. Connected to 122 entities in the SciDEX knowledge graph.

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flowchart TD
    NOS3["NOS3<br/>(Endothelial NOS)"]
    NO["Nitric Oxide<br/>Production"]
    SIRT1["SIRT1<br/>(Sirtuin 1)"]
    NFE2L2["NFE2L2<br/>(Nrf2)"]
    MTOR["MTOR<br/>(mTOR Complex)"]
    BECN1["BECN1<br/>(Beclin-1)"]
    FOXO1["FOXO1<br/>(FoxO1)"]
    MAP3K5["MAP3K5<br/>(ASK1)"]
    STING1["STING1<br/>(STING)"]
    
    Stroke["Stroke<br/>Protection"]
    Ischemia["Ischemic<br/>Injury"]
    MS["Multiple<br/>Sclerosis"]
    Autophagy["Autophagy<br/>Regulation"]
    Oxidative["Oxidative<br/>Stress"]
    Inflammation["Neuroinflammation"]
    Apoptosis["Cell Death<br/>Pathways"]
    Neuroprotection["Neuroprotection"]

    NOS3 --|"produces"|--> NO
    NO --|"activates"|--> SIRT1
    NO --|"activates"|--> NFE2L2
    SIRT1 --|"enhances"|--> NFE2L2
    NFE2L2 --|"reduces"|--> Oxidative
    
    NOS3 --|"inhibits"|--> MTOR
    MTOR --|"inhibits"|--> BECN1
    BECN1 --|"promotes"|--> Autophagy
    SIRT1 --|"activates"|--> FOXO1
    FOXO1 --|"promotes"|--> Autophagy
    
    NOS3 --|"inhibits"|--> MAP3K5
    MAP3K5 --|"promotes"|--> Apoptosis
    NOS3 --|"modulates"|--> STING1
    STING1 --|"promotes"|--> Inflammation
    
    NO --|"protects_against"|--> Stroke
    NO --|"reduces"|--> Ischemia
    NOS3 --|"therapeutic_for"|--> MS
    Autophagy --|"promotes"|--> Neuroprotection
    NFE2L2 --|"promotes"|--> Neuroprotection

    style NOS3 fill:#006494
    style SIRT1 fill:#1b5e20
    style NFE2L2 fill:#1b5e20
    style BECN1 fill:#4a1a6b
    style FOXO1 fill:#4a1a6b
    style MAP3K5 fill:#ef5350
    style STING1 fill:#ef5350
    style Stroke fill:#5d4400
    style Ischemia fill:#ef5350
    style MS fill:#ef5350
    style Neuroprotection fill:#1b5e20
    style Oxidative fill:#ef5350
    style Inflammation fill:#ef5350
    style Apoptosis fill:#ef5350