HSF1

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

HSF1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, therapeutic target, activates. Associated with Aging, Als, Alzheimer. Connected to 136 entities in the SciDEX knowledge graph.

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graph TD
    HSF1["<b>HSF1</b>"]
    Huntington_s_disease{"Huntington's disease"}
    HSF1 -->|"associated with"| Huntington_s_disease
    DRP1["DRP1"]
    HSF1 -->|"activates"| DRP1
    SSBP1["SSBP1"]
    HSF1 -->|"inhibits"| SSBP1
    Alzheimer{"Alzheimer"}
    HSF1 -->|"expressed in"| Alzheimer
    Aging{"Aging"}
    HSF1 -->|"expressed in"| Aging
    Als{"Als"}
    HSF1 -->|"expressed in"| Als
    Ms{"Ms"}
    HSF1 -->|"expressed in"| Ms
    Dementia{"Dementia"}
    HSF1 -->|"associated with"| Dementia
    Parkinson{"Parkinson"}
    HSF1 -->|"inhibits"| Parkinson
    HSF1 -->|"inhibits"| Als
    HSF1 -->|"inhibits"| Ms
    Cancer{"Cancer"}
    HSF1 -->|"therapeutic target"| Cancer
    DH1["DH1"]
    DH1 -->|"inhibits"| HSF1
    FYN["FYN"]
    FYN -->|"expressed in"| HSF1
    AGING["AGING"]
    AGING -->|"expressed in"| HSF1
    VCP["VCP"]
    VCP -->|"expressed in"| HSF1
    CTNNB1["CTNNB1"]
    CTNNB1 -->|"expressed in"| HSF1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"expressed in"| HSF1
    EGFR["EGFR"]
    EGFR -->|"associated with"| HSF1
    HSP90AA1["HSP90AA1"]
    HSP90AA1 -->|"expressed in"| HSF1
    APP["APP"]
    APP -->|"expressed in"| HSF1
    HSP90AB1["HSP90AB1"]
    HSP90AB1 -->|"expressed in"| HSF1
    MDM2["MDM2"]
    MDM2 -->|"expressed in"| HSF1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"inhibits"| HSF1
    style HSF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0