concept

RRM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RRM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

0Hypotheses

0Analyses

33Outgoing

21Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	RRM1
Key Genes/Proteins	LRP1, CTNNB1, TDP-43, RNA, TCF3, YBX1
Related Diseases	DRUG_RESISTANCE, Carcinoma, Cancer, Tumor

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    RRM1["RRM1"]
    RRM1 -->|"activates"| DRUG_RESISTANCE["DRUG_RESISTANCE"]
    RRM1 -->|"activates"| Carcinoma["Carcinoma"]
    RRM1 -->|"target for"| Cancer["Cancer"]
    RRM1 -->|"target for"| Tumor["Tumor"]
    RRM1 -->|"target for"| YBX1["YBX1"]
    CTNNB1["CTNNB1"] -->|"activates"| RRM1
    TCF3["TCF3"] -->|"activates"| RRM1
    LRP1["LRP1"] -->|"target for"| RRM1
    APOPTOSIS["APOPTOSIS"] -->|"target for"| RRM1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| RRM1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| RRM1
    AND["AND"] -->|"activates"| RRM1
    GENE_MUTATIONS["GENE MUTATIONS"] -->|"activates"| RRM1

Outgoing (33)

Target	Relation	Type	Str
DRUG_RESISTANCE	activates	phenotype	0.72
Carcinoma	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
TDP-43	interacts_with	gene	0.65
YBX1	therapeutic_target	gene	0.60
LRP1	therapeutic_target	gene	0.60
TCF3	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
GENE MUTATIONS	activates	gene	0.60
YBX1	activates	gene	0.60
LRP1	activates	gene	0.60
CANCER	activates	gene	0.60
BCL2	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
CANCER	expressed_in	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
DNA	inhibits	gene	0.60
Cell Cycle	expressed_in	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Immune Response	therapeutic_target	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Protein Aggregation	activates	pathway	0.60
TDP-43	activates	gene	0.60
Tdp-43	activates	pathway	0.60
AND	activates	gene	0.60
Oxidative Stress	stabilizes	pathway	0.60
Tdp-43	stabilizes	protein	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
TDP-43	regulates	gene	0.55

Incoming (21)

Source	Relation	Type	Str
LRP1	regulates	gene	0.80
CTNNB1	activates	protein	0.72
RNA	regulates	gene	0.65
RNA	interacts_with	gene	0.65
TCF3	activates	protein	0.64
LRP1	therapeutic_target	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
AND	activates	gene	0.60
GENE MUTATIONS	activates	gene	0.60
YBX1	activates	gene	0.60
LRP1	activates	gene	0.60
TDP-43	activates	gene	0.60
CANCER	activates	gene	0.60
TDP-43	stabilizes	gene	0.60
HNRNPA2B1	associated_with	gene	0.55
RNA	associated_with	gene	0.55
RNA	expressed_in	gene	0.55
RNA	activates	gene	0.55
AND	interacts_with	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RRM1

Understanding Entity Pages

Wiki Pages (20)

HNRNPA2B1 Protein

ftd-tdp-pathology

TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis

PTBP2 - Polypyrimidine Tract Binding Protein 2

ftd-tdp43-pathway

TAR DNA-Binding Protein 43 (TDP-43)

TDP-43 Protein

HNRNPA1 Protein

Update TDP-43 protein page with comprehensive content

TIAL1 — TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1

HNRNPR Gene

RBM25 Protein

HNRNPA1 Protein

HNRNPG — Heterogeneous Nuclear Ribonucleoprotein G

TIA1 Protein

TIA1L (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like)

U2AF1 — U2AF Auxiliary Factor 1

HNRNPL Gene