concept

RRM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RRM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

54Connections

0Hypotheses

0Analyses

33Outgoing

21Incoming

0Experiments

0Debates

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💡 Concept Info

Name	RRM1
Key Genes/Proteins	AND, APOPTOSIS, BCL2, CANCER, CTNNB1, DNA
Related Diseases	Cancer, Carcinoma, DRUG_RESISTANCE
Related Pathways	Apoptosis, Cell Cycle, Immune Response

Pathway Diagram

graph TD
    RRM1["RRM1"]
    RRM1 -->|"activates"| DRUG_RESISTANCE["DRUG_RESISTANCE"]
    RRM1 -->|"activates"| Carcinoma["Carcinoma"]
    RRM1 -->|"target for"| Cancer["Cancer"]
    RRM1 -->|"target for"| Tumor["Tumor"]
    RRM1 -->|"target for"| YBX1["YBX1"]
    CTNNB1["CTNNB1"] -->|"activates"| RRM1
    TCF3["TCF3"] -->|"activates"| RRM1
    LRP1["LRP1"] -->|"target for"| RRM1
    APOPTOSIS["APOPTOSIS"] -->|"target for"| RRM1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| RRM1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| RRM1
    AND["AND"] -->|"activates"| RRM1
    GENE_MUTATIONS["GENE MUTATIONS"] -->|"activates"| RRM1

Outgoing (33)

Target	Relation	Type	Str
DRUG_RESISTANCE	activates	phenotype	0.72
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
TDP-43	interacts_with	gene	0.65
TDP-43	activates	gene	0.60
Oxidative Stress	stabilizes	pathway	0.60
Tdp-43	stabilizes	protein	0.60
CANCER	expressed_in	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
DNA	inhibits	gene	0.60
Cell Cycle	expressed_in	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
BCL2	therapeutic_target	gene	0.60
Immune Response	therapeutic_target	pathway	0.60
GENES	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
GENE MUTATIONS	activates	gene	0.60
AND	activates	gene	0.60
YBX1	therapeutic_target	gene	0.60
LRP1	therapeutic_target	gene	0.60
TCF3	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
Protein Aggregation	activates	pathway	0.60
Tdp-43	activates	pathway	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
YBX1	activates	gene	0.60
LRP1	activates	gene	0.60
CANCER	activates	gene	0.60
TDP-43	regulates	gene	0.55

Incoming (21)

Source	Relation	Type	Str
LRP1	regulates	gene	0.80
CTNNB1	activates	protein	0.72
RNA	interacts_with	gene	0.65
RNA	regulates	gene	0.65
TCF3	activates	protein	0.64
APOPTOSIS	therapeutic_target	gene	0.60
LRP1	therapeutic_target	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
AND	activates	gene	0.60
GENE MUTATIONS	activates	gene	0.60
YBX1	activates	gene	0.60
LRP1	activates	gene	0.60
TDP-43	activates	gene	0.60
TDP-43	stabilizes	gene	0.60
CANCER	activates	gene	0.60
HNRNPA2B1	associated_with	gene	0.55
RNA	associated_with	gene	0.55
RNA	expressed_in	gene	0.55
RNA	activates	gene	0.55
AND	interacts_with	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity