Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB5A is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, interacts with. Associated with ALS, Als, Ms. Connected to 31 entities in the SciDEX knowledge graph.
| Gene Symbol | RAB5A |
| Full Name | Ras-Related Protein Rab-5A |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 24 kDa |
| Amino Acids | 218 aa |
| Pathways | MAPK signaling |
| Ensembl ID | ENSG00000108510 |
| GeneCards | RAB5A |
| Human Protein Atlas | RAB5A |
| EEA1 | Master organizer of early endosome docking |
| Rabenosyn-5 | Cargo sorting and transport |
| FYCO1 | Lysosomal trafficking and autophagosome-lysosome fusion |
| P38α | MAPK signaling scaffold |
| SAND-1/Mon1 | HOPS complex recruitment |
| Associated Diseases | ALS |
| Interactions | NEURODEGENERATIVE DISEASES |
| KG Connections | 32 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAB5A["<b>RAB5A</b>"]
Als{"Als"}
RAB5A -->|"associated with"| Als
RAB5A -->|"therapeutic target"| Als
Ms{"Ms"}
RAB5A -->|"interacts with"| Ms
ALS{"ALS"}
RAB5A -->|"associated with"| ALS
RAB11B["RAB11B"]
RAB5A -->|"associated with"| RAB11B
RAB10["RAB10"]
RAB5A -->|"associated with"| RAB10
RAB3A["RAB3A"]
RAB5A -->|"associated with"| RAB3A
Exocytosis(["Exocytosis"])
RAB5A -->|"associated with"| Exocytosis
RAB5["RAB5"]
RAB5A -->|"associated with"| RAB5
RAB27B["RAB27B"]
RAB5A -->|"associated with"| RAB27B
HSPA1A["HSPA1A"]
RAB5A -->|"therapeutic target"| HSPA1A
RAB8A["RAB8A"]
RAB5A -->|"therapeutic target"| RAB8A
RAB4B["RAB4B"]
RAB4B -->|"associated with"| RAB5A
RAB27B -->|"associated with"| RAB5A
RAB3C["RAB3C"]
RAB3C -->|"associated with"| RAB5A
RAB5 -->|"associated with"| RAB5A
RAB3B["RAB3B"]
RAB3B -->|"associated with"| RAB5A
RAB3A -->|"associated with"| RAB5A
RAB10 -->|"associated with"| RAB5A
RAB11B -->|"associated with"| RAB5A
RAB7A["RAB7A"]
RAB7A -->|"therapeutic target"| RAB5A
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
NEURODEGENERATIVE_DISEASES -->|"interacts with"| RAB5A
IGF2R["IGF2R"]
IGF2R -->|"therapeutic target"| RAB5A
CAPZB["CAPZB"]
CAPZB -->|"therapeutic target"| RAB5A
style RAB5A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| RAB11B | associated_with | gene | 0.60 |
| RAB10 | associated_with | gene | 0.60 |
| RAB3A | associated_with | gene | 0.60 |
| RAB5 | associated_with | gene | 0.60 |
| RAB27B | associated_with | gene | 0.60 |
| HSPA1A | therapeutic_target | gene | 0.60 |
| RAB8A | therapeutic_target | gene | 0.60 |
| CANX | therapeutic_target | gene | 0.60 |
| HSPA5 | therapeutic_target | gene | 0.60 |
| RAB3B | associated_with | gene | 0.60 |
| RAB3C | associated_with | gene | 0.60 |
| RAB4B | associated_with | gene | 0.60 |
| Synaptic Vesicle | associated_with | pathway | 0.60 |
| Exocytosis | associated_with | pathway | 0.60 |
| AND | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RAB4B | associated_with | gene | 0.60 |
| RAB27B | associated_with | gene | 0.60 |
| RAB3C | associated_with | gene | 0.60 |
| RAB5 | associated_with | gene | 0.60 |
| RAB3B | associated_with | gene | 0.60 |
| RAB3A | associated_with | gene | 0.60 |
| RAB10 | associated_with | gene | 0.60 |
| RAB11B | associated_with | gene | 0.60 |
| RAB7A | therapeutic_target | gene | 0.60 |
| IGF2R | therapeutic_target | gene | 0.60 |
| CAPZB | therapeutic_target | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | interacts_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||