gene

RAB5A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections
0Hypotheses
0Analyses
19Outgoing
13Incoming

Summary

RAB5A is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, interacts with. Associated with ALS, Als, Ms. Connected to 31 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRAB5A
Full NameRas-Related Protein Rab-5A
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight24 kDa
Amino Acids218 aa
PathwaysMAPK signaling
Ensembl IDENSG00000108510
GeneCardsRAB5A
Human Protein AtlasRAB5A
EEA1Master organizer of early endosome docking
Rabenosyn-5Cargo sorting and transport
FYCO1Lysosomal trafficking and autophagosome-lysosome fusion
P38αMAPK signaling scaffold
SAND-1/Mon1HOPS complex recruitment
Associated DiseasesALS
InteractionsNEURODEGENERATIVE DISEASES
KG Connections32 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

RAB5A — Ras-Related Protein Rab-5A

gene · 1852 words

RAB4B Gene

gene · 2951 words

synaptic-vesicle-trafficking-pathway

mechanism · 2944 words

RABEP1

gene · 2731 words

Endosomal-Lysosomal Pathway in Neurodegeneration

mechanism · 2413 words

Rab5 Protein

protein · 2270 words

Pathway Diagram

graph TD
    RAB5A["<b>RAB5A</b>"]
    Als{"Als"}
    RAB5A -->|"associated with"| Als
    RAB5A -->|"therapeutic target"| Als
    Ms{"Ms"}
    RAB5A -->|"interacts with"| Ms
    ALS{"ALS"}
    RAB5A -->|"associated with"| ALS
    RAB11B["RAB11B"]
    RAB5A -->|"associated with"| RAB11B
    RAB10["RAB10"]
    RAB5A -->|"associated with"| RAB10
    RAB3A["RAB3A"]
    RAB5A -->|"associated with"| RAB3A
    Exocytosis(["Exocytosis"])
    RAB5A -->|"associated with"| Exocytosis
    RAB5["RAB5"]
    RAB5A -->|"associated with"| RAB5
    RAB27B["RAB27B"]
    RAB5A -->|"associated with"| RAB27B
    HSPA1A["HSPA1A"]
    RAB5A -->|"therapeutic target"| HSPA1A
    RAB8A["RAB8A"]
    RAB5A -->|"therapeutic target"| RAB8A
    RAB4B["RAB4B"]
    RAB4B -->|"associated with"| RAB5A
    RAB27B -->|"associated with"| RAB5A
    RAB3C["RAB3C"]
    RAB3C -->|"associated with"| RAB5A
    RAB5 -->|"associated with"| RAB5A
    RAB3B["RAB3B"]
    RAB3B -->|"associated with"| RAB5A
    RAB3A -->|"associated with"| RAB5A
    RAB10 -->|"associated with"| RAB5A
    RAB11B -->|"associated with"| RAB5A
    RAB7A["RAB7A"]
    RAB7A -->|"therapeutic target"| RAB5A
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| RAB5A
    IGF2R["IGF2R"]
    IGF2R -->|"therapeutic target"| RAB5A
    CAPZB["CAPZB"]
    CAPZB -->|"therapeutic target"| RAB5A
    style RAB5A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

TargetRelationTypeStr
Alsassociated_withdisease0.65
Alstherapeutic_targetdisease0.65
Msinteracts_withdisease0.65
ALSassociated_withdisease0.65
RAB11Bassociated_withgene0.60

Incoming (14)

SourceRelationTypeStr
RAB4Bassociated_withgene0.60
RAB27Bassociated_withgene0.60
RAB3Cassociated_withgene0.60
RAB5associated_withgene0.60
RAB3Bassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found