gene

SLC22A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC22A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections
0Hypotheses
0Analyses
12Outgoing
31Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolSLC22A1
Full NameSolute Carrier Family 22 Member 1 (OCT1)
Chromosome11q13.4
Functionencodes a polytopic membrane protein with 12 predicted transmembrane domains, characteristic of the major facilitator superfamily (MFS).
Molecular Weight~61 kDa
Amino Acids554 aa
Exons12
UniProt IDO15245
NCBI Gene ID6579
Ensembl IDENSG00000175084
OMIM607607
GeneCardsSLC22A1
Human Protein AtlasSLC22A1
Protein NameOrganic Cation Transporter 1
Protein Size554 amino acids
Associated Diseasesneurodegeneration
InteractionsCHRNA7, PPAR, CYP3A4, DEMENTIA, Proteins, ABCB1
KG Connections43 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SLC22A1 — AlphaFold O15245 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

slc22a1

gene · 2913 words

GPR161 — G Protein-Coupled Receptor 161

gene · 2976 words

slc22a5

gene · 2245 words

Section 216: Advanced Pharmacogenomics for CBS/PSP

therapeutic · 2181 words

Section 160: Pharmacogenomics and Personalized Medicine in CBS/PSP

therapeutic · 2046 words

Ethnicity-Specific Genetic Architecture Hypothesis in Parkinson's Disease

hypothesis · 1749 words

Pathway Diagram

graph TD
    SLC22A1["<b>SLC22A1</b>"]
    Vascular_Dementia["Vascular Dementia"]
    SLC22A1 -->|"transports"| Vascular_Dementia
    Alzheimer["Alzheimer"]
    SLC22A1 -->|"transports"| Alzheimer
    Dementia["Dementia"]
    SLC22A1 -->|"transports"| Dementia
    ALS["ALS"]
    SLC22A1 -->|"transports"| ALS
    Frontotemporal_Dementia["Frontotemporal Dementia"]
    SLC22A1 -->|"transports"| Frontotemporal_Dementia
    CYP3A4["CYP3A4"]
    SLC22A1 -->|"transports"| CYP3A4
    PPAR["PPAR"]
    PPAR -->|"transports"| SLC22A1
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"transports"| SLC22A1
    GENES["GENES"]
    GENES -->|"transports"| SLC22A1
    APOE["APOE"]
    APOE -->|"transports"| SLC22A1
    ABCB1["ABCB1"]
    ABCB1 -->|"transports"| SLC22A1
    CHAT["CHAT"]
    CHAT -->|"transports"| SLC22A1
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"transports"| SLC22A1
    ACE["ACE"]
    ACE -->|"transports"| SLC22A1
    POR["POR"]
    POR -->|"transports"| SLC22A1
    BCHE["BCHE"]
    BCHE -->|"transports"| SLC22A1
    CYP3A5["CYP3A5"]
    CYP3A5 -->|"transports"| SLC22A1
    NR1I2["NR1I2"]
    NR1I2 -->|"transports"| SLC22A1
    AND["AND"]
    AND -->|"transports"| SLC22A1
    CHRNA7["CHRNA7"]
    CHRNA7 -->|"transports"| SLC22A1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"transports"| SLC22A1
    CYP2D6["CYP2D6"]
    CYP2D6 -->|"transports"| SLC22A1
    Neuron["Neuron"]
    SLC22A1 -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    SLC22A1 -->|"implicated in"| neurodegeneration

Outgoing (12)

TargetRelationTypeStr
Vascular Dementiatransportsdisease0.65
Alzheimertransportsdisease0.65
Dementiatransportsdisease0.65
ALStransportsdisease0.65
Frontotemporal Dementiatransportsdisease0.65

Incoming (31)

SourceRelationTypeStr
PPARtransportsgene0.60
APOEtransportsgene0.60
ABCB1transportsgene0.60
CHATtransportsgene0.60
ACEtransportsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found