concept

POR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about POR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

102Connections

21Hypotheses

28Analyses

50Outgoing

42Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	POR
Related Diseases	Als, Ms, ALS, Parkinson, Alzheimer
Related Pathways	Ferroptosis
Linked Hypotheses	38 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

Lipid Peroxidation in Neurodegeneration

mechanism · 1938 words

→

Pathway Diagram

graph TD
    POR["POR"]
    POR -->|"activates"| Als["Als"]
    POR -->|"activates"| Ms["Ms"]
    POR -->|"activates"| ALS["ALS"]
    POR -->|"target for"| Parkinson["Parkinson"]
    POR -->|"target for"| Dementia["Dementia"]
    LPCAT3["LPCAT3"] -->|"regulates"| POR
    ACSL4["ACSL4"] -->|"regulates"| POR
    NOX["NOX"] -->|"activates"| POR
    SPHK1["SPHK1"] -->|"interacts"| POR
    SOAT1["SOAT1"] -->|"interacts"| POR
    AUTOPHAGY["AUTOPHAGY"] -->|"interacts"| POR

Outgoing (60)

Target	Relation	Type	Str
Als	activates	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
ALS	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Dementia	therapeutic_target	disease	0.65
Vascular Dementia	associated_with	disease	0.65
Dementia	transports	disease	0.65
ALS	associated_with	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Als	transports	disease	0.65
LIPID_PEROXIDATION	activates	phenotype	0.64
Ferroptosis	regulates	pathway	0.60
Autophagy	interacts_with	pathway	0.60
NOX	activates	gene	0.60
ACSL4	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
LPCAT3	regulates	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
Complement	associated_with	pathway	0.60
LPCAT3	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
SOAT1	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AND	activates	gene	0.60
ROS	activates	gene	0.60
CYP3A5	therapeutic_target	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CHAT	therapeutic_target	gene	0.60
CYP3A4	therapeutic_target	gene	0.60
APOE	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
CYP2D6	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
ACE	therapeutic_target	gene	0.60
NR1I2	therapeutic_target	gene	0.60
CHRNA7	therapeutic_target	gene	0.60
PPAR	therapeutic_target	gene	0.60
Neuron	therapeutic_target	cell_type	0.60
BCHE	transports	gene	0.60
CYP3A5	transports	gene	0.60
NR1I2	transports	gene	0.60
AND	transports	gene	0.60
CHRNA7	transports	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
CYP2D6	transports	gene	0.60

Incoming (42)

Source	Relation	Type	Str
LPCAT3	regulates	gene	0.60
ACSL4	regulates	gene	0.60
NOX	activates	gene	0.60
NOX	regulates	gene	0.60
SPHK1	interacts_with	gene	0.60
LPCAT3	interacts_with	gene	0.60
SOAT1	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
MLKL	interacts_with	gene	0.60
GPX4	interacts_with	gene	0.60
ROS	activates	gene	0.60
AND	interacts_with	gene	0.60
PPAR	transports	gene	0.60
DEMENTIA	transports	gene	0.60
GENES	transports	gene	0.60
APOE	transports	gene	0.60
ABCB1	transports	gene	0.60
CHAT	transports	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ACE	transports	gene	0.60
FERROPTOSIS	regulates	gene	0.60
APOE	therapeutic_target	gene	0.60
CHRNA7	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
NR1I2	therapeutic_target	gene	0.60
PPAR	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
CHAT	therapeutic_target	gene	0.60
CYP2D6	therapeutic_target	gene	0.60
CYP3A5	therapeutic_target	gene	0.60
CYP3A4	therapeutic_target	gene	0.60
ABCB1	regulates	gene	0.60
ACE	regulates	gene	0.60
CHAT	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
CYP2D6	regulates	gene	0.60
CYP3A4	regulates	gene	0.60
CYP3A5	regulates	gene	0.60
NR1I2	regulates	gene	0.60
APOE	interacts_with	gene	0.60
CYP2C19	regulates	gene	0.60

Targeting Hypotheses (21)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Temporal SPP1 Inhibition During Critical Windows	0.650	neuroinflammation	What molecular mechanisms mediate SPP1-i
SASP-Driven Aquaporin-4 Dysregulation	0.590	neurodegeneration	Senolytic therapy for age-related neurod
Parvalbumin Interneuron Vulnerability Links Lactate Transpor	0.569	neurodegeneration	What is the molecular mechanism by which
ER Stress Reduction as Adjunctive Therapy to Support Autopha	0.566	neurodegeneration	Why does iron chelation therapy worsen o
Temporal Decoupling via Circadian Clock Reset	0.516	neurodegeneration	Microglia-astrocyte crosstalk amplificat

Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mi	0.511	neurodegeneration	CRISPR-based therapeutic approaches for
Aquaporin-4 Polarization Rescue	0.507	neurodegeneration	4R-tau strain-specific spreading pattern
Temporal Metabolic Window Therapy	0.506	neurodegeneration	How do astrocyte-neuron metabolic intera
SIRT1-Mediated Epigenetic Restoration of MFSD2A Expression R	0.498	neuropharmacology	What determines blood-brain barrier pene
FcRn Transport Bypass Strategy	0.480	neuropharmacology	What is the actual quantitative contribu
Temporal Microglial State Switching	0.462	-	Neuroinflammation and microglial priming
BMP4 Pathway Inhibition for Oligodendrocyte Myelination Supp	0.454	neurodegeneration	Cell type vulnerability in Alzheimer's D
Axonal RNA Transport Reconstitution	0.446	neurodegeneration	RNA binding protein dysregulation across
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu	0.437	neurodegeneration	Perivascular spaces and glymphatic clear
AP1S1-Mediated Vesicular Transport Restoration	0.416	neurodegeneration	Gene expression changes in aging mouse b
Correcting Gut Microbial Dopamine Imbalance to Support Syste	0.412	neurodegeneration	What are the mechanisms by which gut mic
Temporal TET2-Mediated Hydroxymethylation Cycling	0.408	neurodegeneration	Epigenetic reprogramming in aging neuron
Brain Insulin Resistance with Glucose Transporter Dysfunctio	0.398	neurodegeneration	Metabolic reprogramming in neurodegenera
Temporal Gating of Microglial Responses	0.389	Alzheimer's disease	Neuroinflammation and microglial priming
Temporal TFEB Modulation Therapy	0.366	neurodegeneration	Does TFEB dysfunction cause neurodegener
Synthetic Biology Approach: Designer Mitochondrial Export Sy	0.358	neurodegeneration	Mitochondrial transfer between neurons a

Mentioning Analyses (28)

Scientific analyses that reference this entity

What determines the GPX4/ACSL4 balance that switches microglia from protective t

immunology | 2026-04-15 | 0 hypotheses

What is the temporal sequence of TREM2 signaling transition from protective to i

neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674

What are the precise temporal dynamics of astrocyte ketone production decline du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.645

How does pericyte senescence mechanistically promote glioma cell growth and inva

neurodegeneration | 2026-04-14 | 0 hypotheses

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.614

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Aquaporin-4 in glymphatic system, and its implication for central nervous system [PMID:36796590]	Peng S, Liu J, Liang C, Yang L, Wang G	Neurobiol Dis	2023	2
Uncommon inflammatory/immune-related myelopathies. [PMID:34715593]	Valencia-Sanchez C, Flanagan EP	J Neuroimmunol	2021	2
Circadian Rhythms in Gastroenterology: The Biological Clock's Impact on Gut Heal [PMID:40588189]	Bishehsari F, Post Z, Swanson GR, Keshav	Gastroenterology	2025	1
From geroscience to precision geromedicine: Understanding and managing aging. [PMID:40250404]	Kroemer G, Maier AB, Cuervo AM, Gladyshe	Cell	2025	1
Circadian disruption, clock genes, and metabolic health. [PMID:39007272]	Schrader LA, Ronnekleiv-Kelly SM, Hogene	J Clin Invest	2024	1
B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. [PMID:38383779]	Afzali AM, Nirschl L, Sie C, Pfaller M,	Nature	2024	1
Biomarkers of aging for the identification and evaluation of longevity intervent [PMID:37657418]	Moqri M, Herzog C, Poganik JR, Biomarker	Cell	2023	1
Clocks, cancer, and chronochemotherapy. [PMID:33384351]	Sancar A, Van Gelder RN	Science	2021	1
Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressu [PMID:31959516]	Reeves BC, Karimy JK, Kundishora AJ, Mes	Trends Mol Med	2020	1
Inebilizumab-cdon. [PMID:32936251]	Unknown	American journal of health-sys	2020	1
The glymphatic pathway in neurological disorders. [PMID:30353860]	Rasmussen MK, Mestre H, Nedergaard M	Lancet Neurol	2018	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Epigenetics and the gut-brain axis: Insights into DNA methylation, aging, and Al [PMID:41886887]	Kumar V, Shukla R, Gangani S, Joseph R,	The Journal of pharmacology an	2026	0
Effects of circadian rhythms on antimicrobial peptide concentrations in lactatin [PMID:41923233]	Liang ZL, Nii T, Sugino T, Isobe N	BMC veterinary research	2026	0
Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646]	Lin L, Liang X, Xu Z, Li Y, Guo Z et al.	Biomaterials	2026	0
Pharmacological modulation of circadian rhythms in brain microvasculature. [PMID:41355044]	Yang Z, Kim M, Montgomery M, Lewandowski	J Cereb Blood Flow Metab	2026	0
The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525]	Sica V, Sato T, Tsialtas I, Hernandez S,	J Biol Rhythms	2026	0
When Clocks Go Rogue: Circadian Rhythms and the Rise of Cancer. [PMID:41520235]	Robinson AS, Bennett S, Sato S	J Biol Rhythms	2026	0
Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008]	Tsameret S, Froy O, Matz Y, Landau Z, Tw	Diabetologia	2026	0
Circadian locomotor activity-rest rhythm in Drosophila is regulated by microRNA- [PMID:41632758]	Anna G, Tharayil Jayalal N, Jayan A, Ran	Genetics	2026	0

POR

Understanding Entity Pages

Wiki Pages (1)

Lipid Peroxidation in Neurodegeneration

Pathway Diagram

Outgoing (60)

Incoming (42)

Targeting Hypotheses (21)

Mentioning Analyses (28)

What determines the GPX4/ACSL4 balance that switches microglia from protective t

What is the temporal sequence of TREM2 signaling transition from protective to i

What are the precise temporal dynamics of astrocyte ketone production decline du

How does pericyte senescence mechanistically promote glioma cell growth and inva

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

What determines blood-brain barrier penetration kinetics for specialized pro-res

What is the actual quantitative contribution of FcRn-mediated transcytosis to BB

What is the temporal sequence of sleep disruption versus amyloid-beta accumulati

What validated biomarkers can determine optimal TFEB activity windows during dis

What is the optimal BBB opening duration and spatial precision to maximize thera

What are the optimal timing windows for TREM2 inhibition vs activation in Alzhei

What are the optimal temporal windows for TREM2 inhibition vs activation in Alzh

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

Are autophagy-lysosome defects primary drivers or downstream consequences in spo

Why does prolonged anesthesia cause both cognitive dysfunction and anxiety throu

How does chronic cGAS/STING activation downstream of TDP-43 contribute to progre

What is the optimal therapeutic window timing for autophagy enhancement versus s

Which tau propagation mechanism predominates in different brain regions and dise

What are the specific molecular mechanisms by which AQP4 dysfunction contributes

What is the optimal therapeutic window during preclinical AD for epigenetic repr

How can AQP4 be effectively targeted therapeutically to improve neurological out

APOE4-driven lipid metabolism dysregulation in astrocytes and its role in AD

How do astrocyte-neuron metabolic interactions change during disease progression

Lipid metabolism dysregulation and membrane integrity in Alzheimer disease

Blood-brain barrier antibody transport mechanisms

Blood-brain barrier transport mechanisms for antibody therapeutics

Related Papers (20)