concept

IL-1BETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-1BETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

53Connections

0Hypotheses

1Analyses

35Outgoing

17Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	IL-1BETA
Key Genes/Proteins	PARKINSON, TNF, INFLAMMATION, AND, NEURODEGENERATIVE DISEASES, PARKINSON'S DISEASE
Related Diseases	Neurodegeneration, Als, Parkinson, Neuroinflammation, Tumor

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IL_1BETA["IL-1BETA"]
    IL_1BETA -->|"activates"| Neurodegeneration["Neurodegeneration"]
    IL_1BETA -->|"activates"| Als["Als"]
    IL_1BETA -->|"activates"| Parkinson["Parkinson"]
    IL_1BETA -->|"activates"| Neuroinflammation["Neuroinflammation"]
    IL_1BETA -->|"activates"| Tumor["Tumor"]
    IL_1BETA -->|"activates"| ALS["ALS"]
    IL_1BETA -->|"activates"| Inflammation["Inflammation"]
    IL_1BETA -->|"activates"| PARKINSON["PARKINSON"]
    MICROGLIA["MICROGLIA"] -->|"activates"| IL_1BETA
    NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| IL_1BETA
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| IL_1BETA
    PARKINSON -->|"activates"| IL_1BETA
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| IL_1BETA
    CYTOKINES["CYTOKINES"] -->|"activates"| IL_1BETA
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| IL_1BETA
    BCL2["BCL2"] -->|"regulates"| IL_1BETA

Outgoing (35)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Parkinson	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	activates	disease	0.65
PARKINSON	activates	gene	0.60
TNF	associated_with	gene	0.60
Microglia	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
INFLAMMATION	activates	gene	0.60
AND	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
Il-1	associated_with	protein	0.60
App	associated_with	protein	0.60
Substantia Nigra	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
MICROGLIA	activates	cell_type	0.50
SQSTM1	regulates	gene	0.45
IL6	regulates	gene	0.45
TNF	regulates	gene	0.35
TNF	expressed_in	gene	0.35
IL-6	expressed_in	gene	0.35
TNF	activates	gene	0.35
INFLAMMATION	regulates	process	0.30
NF-KB	regulates	gene	0.30
IL6	therapeutic_target	gene	0.30
NEUROGENESIS	activates	process	0.30
IL6	activates	gene	0.30
TNF	protects_against	gene	0.30
OXIDATIVE STRESS	regulates	process	0.30
TP53	regulates	gene	0.30

Incoming (18)

Source	Relation	Type	Str
MICROGLIA	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
TNF	associated_with	gene	0.60
APOPTOSIS	regulates	process	0.45
CYTOKINES	activates	protein	0.35
AUTOPHAGY	regulates	process	0.30
BCL2	regulates	gene	0.30
APOPTOSIS	activates	process	0.30
APOPTOSIS	protects_against	process	0.30
CYTOKINES	protects_against	protein	0.30
CASP3	protects_against	gene	0.30
BCL2	protects_against	gene	0.30
BAX	protects_against	gene	0.30
CYTOKINES	regulates	protein	0.30
FADD	regulates	gene	0.30

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.780

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL-1BETA

Understanding Entity Pages

Wiki Pages (20)

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Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

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Blood-Brain Barrier Biology and Crossing Strategies

Infectious Triggers in Alzheimer's Disease

prion-disease

Neuronal Ceroid Lipofuscinosis (NCL)

Curcumin for Neurodegeneration

creatine-supplementation-neurodegeneration

Neuroinflammation-Mitochondria Crosstalk Pathway

GBA1→GCase→Lysosome→PD Causal Chain

Microglial Senescence Pathway in Neurodegeneration

Gut-Brain Axis in Neurodegeneration

Notch Signaling Pathway in Neurodegeneration

NF-kB Signaling Pathway in Neurodegeneration

Pannexin 1 and P2X7 Receptor Signaling in Neurodegeneration