gene

UBB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections
0Hypotheses
0Analyses
11Outgoing
6Incoming

Summary

UBB is a gene implicated in neurodegeneration research. Key relationships include: regulates, therapeutic target, implicated in. Associated with Inflammation, Osteoarthritis. Connected to 18 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolUBB
Full NameUbiquitin B
Protein TypeLigase
FunctionUBB produces polyubiquitin chains that are processed into单体 ubiquitin
PathwaysMitophagy
Ensembl IDENSG00000104140
GeneCardsUBB
Human Protein AtlasUBB
Protein degradationUbiquitin tags proteins for proteasomal or lysosomal degradation<sup>[1]</sup>
Signal transductionUbiquitin serves as a signaling molecule
DNA repairUbiquitin participates in DNA damage response
EndocytosisUbiquitin marks membrane proteins for endocytosis
Quality controlUbiquitin targets misfolded and damaged proteins
Associated Diseasesneurodegeneration
KG Connections17 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

UBB — Ubiquitin B

gene · 592 words

Ubiquitin-Proteasome System Dysfunction in Parkinson's Disease

mechanism · 3071 words

PINK1-Parkin Mitophagy Pathway in Parkinson's Disease

mechanism · 2896 words

Ubiquitin-Proteasome System Dysfunction in Alzheimer's Disease

mechanism · 2210 words

Proteasomal Pathway in Neurodegeneration

mechanism · 1803 words

UBC Protein

protein · 1620 words

Pathway Diagram

graph TD
    UBB["<b>UBB</b>"]
    neurodegeneration{"neurodegeneration"}
    UBB -->|"implicated_in"| neurodegeneration
    UBC["UBC"]
    UBB -->|"regulates"| UBC
    GENES["GENES"]
    UBB -->|"therapeutic_target"| GENES
    LC3["LC3"]
    UBB -->|"regulates"| LC3
    MAP1LC3B["MAP1LC3B"]
    UBB -->|"regulates"| MAP1LC3B
    TOMM40["TOMM40"]
    UBB -->|"regulates"| TOMM40
    ATG12["ATG12"]
    UBB -->|"regulates"| ATG12
    ULK1["ULK1"]
    UBB -->|"regulates"| ULK1
    Osteoarthritis{"Osteoarthritis"}
    UBB -->|"therapeutic_target"| Osteoarthritis
    Inflammation{"Inflammation"}
    UBB -->|"therapeutic_target"| Inflammation
    Oxidative_Stress["Oxidative Stress"]
    UBB -->|"therapeutic_target"| Oxidative_Stress
    Mitophagy["Mitophagy"]
    UBB -->|"regulates"| Mitophagy
    GFP["GFP"]
    GFP -->|"therapeutic_target"| UBB
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"regulates"| UBB
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"therapeutic_target"| UBB
    CSNK2B["CSNK2B"]
    CSNK2B -->|"regulates"| UBB
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"therapeutic_target"| UBB
    TOMM20["TOMM20"]
    TOMM20 -->|"therapeutic_target"| UBB
    style UBB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (11)

TargetRelationTypeStr
Osteoarthritistherapeutic_targetdisease0.65
Inflammationtherapeutic_targetdisease0.65
UBCregulatesgene0.60
LC3regulatesgene0.60
MAP1LC3Bregulatesgene0.60

Incoming (6)

SourceRelationTypeStr
CSNK2Bregulatesgene0.60
TOMM20therapeutic_targetgene0.60
GFPtherapeutic_targetgene0.60
MITOPHAGYregulatesgene0.60
OXIDATIVE STRESStherapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found