gene

UBR5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBR5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

18Outgoing

9Incoming

Summary

Page for UBR5 - Ubiquitin-Protein Ligase E3 Component N-Recognin 5

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🧬 Gene Info

Gene Symbol	UBR5
Full Name	Ubiquitin-Protein Ligase E3 Component N-Recognin 5
Aliases	Page for UBR5
Chromosome	8q22.3
Protein Type	Ligase
Function	UBR5 is a HECT-domain E3 ubiquitin ligase with multiple cellular functions:
Primary Expression	Ubiquitous, Brain (high), Testis
Pathways	Chemoresistance, Circadian Rhythm, Ferroptosis, Proteasome, Ubiquitin-Proteasome
UniProt ID	O95071
NCBI Gene ID	51366
Ensembl ID	ENSG00000146233
GeneCards	UBR5
Human Protein Atlas	UBR5
Interactions	PER2, CLOCK, BMAL1, UBIQUITIN, SLC7A11, TNF
KG Connections	27 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: UBR5 — AlphaFold O95071 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    UBR5["<b>UBR5</b>"]
    PER2["PER2"]
    UBR5 -->|"inhibits"| PER2
    CLOCK["CLOCK"]
    UBR5 -->|"inhibits"| CLOCK
    BMAL1["BMAL1"]
    UBR5 -->|"inhibits"| BMAL1
    CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    UBR5 -->|"regulates"| CIRCADIAN_RHYTHM
    Proteasome(["Proteasome"])
    UBR5 -->|"regulates"| Proteasome
    Ubiquitin_Proteasome(["Ubiquitin-Proteasome"])
    UBR5 -->|"regulates"| Ubiquitin_Proteasome
    Circadian_Rhythm(["Circadian Rhythm"])
    UBR5 -->|"regulates"| Circadian_Rhythm
    neurodegeneration["neurodegeneration"]
    UBR5 -->|"implicated in"| neurodegeneration
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"inhibits"| UBR5
    style UBR5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (18)

Target	Relation	Type	Str
Proteasome	activates	pathway	0.70
Colorectal Cancer	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	activates	disease	0.65
Als	therapeutic_target	disease	0.65
PER2	inhibits	gene	0.60
CLOCK	inhibits	gene	0.60
BMAL1	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
ATF3	therapeutic_target	gene	0.60
UBIQUITIN	causes	gene	0.60
CIRCADIAN RHYTHM	regulates	gene	0.60
Proteasome	regulates	pathway	0.60
Ubiquitin-Proteasome	regulates	pathway	0.60
Circadian Rhythm	regulates	pathway	0.60
Ferroptosis	regulates	pathway	0.60
Chemoresistance	regulates	pathway	0.60
Nf-Κb	activates	pathway	0.60

Incoming (9)

Source	Relation	Type	Str
UBIQUITIN	inhibits	gene	0.60
SLC7A11	inhibits	gene	0.60
SMAD3	regulates	gene	0.60
TNF	activates	gene	0.60
OTUD5	associated_with	gene	0.60
FERROPTOSIS	regulates	gene	0.60
CANCER	inhibits	gene	0.60
NF-ΚB	activates	gene	0.60
TNF-Α	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found