gene

OTUD5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OTUD5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

73Connections

0Hypotheses

0Analyses

50Outgoing

20Incoming

Summary

OTUD5 (OTU Deubiquitinase 5) - a deubiquitinase enzyme implicated in Parkinson's disease and dopaminergic neuron protection through regulation of alpha-synuclein degradation

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🧬 Gene Info

Gene Symbol	OTUD5
Aliases	OTU Deubiquitinase 5
Chromosome	Chromosome Xp11.23
Protein Type	Protease
Function	is a member of the ovarian tumor (OTU) family of deubiquitinating enzymes that catalyzes the removal of ubiquitin from target proteins.
Molecular Weight	~48 kDa
Amino Acids	446 aa
Exons	7
Pathways	Ferroptosis
GeneCards	OTUD5
Human Protein Atlas	OTUD5
Official Name	OTU Deubiquitinase 5
Previous Symbols	SARS, DEXR1
genomic coordinates	X: 48,934,288-48,971,633
Strand	Positive strand
Associated Diseases	neurodegeneration
Interactions	GPX4, S100B, Rb, THBS1, NF-ΚB, TNF-Α
KG Connections	73 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    OTUD5["<b>OTUD5</b>"]
    Ischemia{"Ischemia"}
    OTUD5 -->|"protects against"| Ischemia
    Ms{"Ms"}
    OTUD5 -->|"therapeutic target"| Ms
    Tumor{"Tumor"}
    OTUD5 -->|"inhibits"| Tumor
    ALDH2["ALDH2"]
    OTUD5 -->|"therapeutic target"| ALDH2
    Ferroptosis(["Ferroptosis"])
    OTUD5 -->|"therapeutic target"| Ferroptosis
    neurodegeneration["neurodegeneration"]
    OTUD5 -->|"implicated in"| neurodegeneration
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"therapeutic target"| OTUD5
    GPX4["GPX4"]
    GPX4 -->|"therapeutic target"| OTUD5
    style OTUD5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (53)

Target	Relation	Type	Str
Ischemia	protects_against	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Tumor	regulates	disease	0.65
Parkinson	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ischemia	activates	disease	0.65
Stroke	activates	disease	0.65
ALDH2	therapeutic_target	gene	0.60
UBR5	associated_with	gene	0.60
UBIQUITIN	causes	gene	0.60
GPX4	inhibits	gene	0.60
S100B	activates	gene	0.60
Podocyte	inhibits	cell_type	0.60
Rb	activates	protein	0.60
ferroptosis	participates_in	pathway	0.60
ubiquitination	activates	process	0.60
ubiquitination	inhibits	process	0.60
THBS1	activates	gene	0.60
THBS1	inhibits	gene	0.60
THBS1	regulates	gene	0.60
Ferroptosis	therapeutic_target	pathway	0.60
NF-ΚB	activates	gene	0.60
TNF-Α	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
Proteasome	activates	pathway	0.60
NEURODEGENERATION	regulates	gene	0.60
PARKINSON	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
Lysosomal Degradation	activates	pathway	0.60
EXOSOMES	activates	gene	0.60
BRAIN INJURY	regulates	gene	0.60
RNA	activates	gene	0.60
AND	inhibits	gene	0.60
FERROPTOSIS	regulates	gene	0.60
STROKE	activates	gene	0.60
Ferroptosis	regulates	pathway	0.60
Endothelial	activates	cell_type	0.60
Macrophage	regulates	cell_type	0.60
Monocyte	activates	cell_type	0.60
Ubiquitin	inhibits	protein	0.60
Fus	activates	protein	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
macrophages	expressed_in	cell_type	0.60
neurons	expressed_in	cell_type	0.60
Endothelial Cell	expressed_in	cell_type	0.55
Macrophage	expressed_in	cell_type	0.55
ferroptosis	regulates	phenotype	0.50
ENDOTHELIAL	activates	concept	0.50

Incoming (20)

Source	Relation	Type	Str
THBS1	binds	protein	0.90
GPX4	therapeutic_target	gene	0.60
TNF	activates	gene	0.60
GPX4	degrades	entity	0.60
GPX4	mediates	entity	0.60
GPX4	inhibits	gene	0.60
S100B	activates	gene	0.60
TAK1	inhibits	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
AND	associated_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
PARKINSON	activates	gene	0.60
STROKE	activates	gene	0.60
EXOSOMES	activates	gene	0.60
RNA	activates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
BRAIN INJURY	regulates	gene	0.60
GPX4	activates	gene	0.50
GPX4	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

OTUD5

Understanding Entity Pages

Summary

Wiki Pages (6)

OTUD5 Gene

Parkinson's Disease

TDP-43 Proteinopathy

SNCA→Alpha-synuclein→Parkinson's Disease Causal Chain