gene

DDC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

116Connections

1Hypotheses

1Analyses

50Outgoing

34Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	DDC
Chromosome	7p12.2
Protein Type	Enzyme
Function	This is critical for PD treatment, as the efficacy of L-DOPA therapy depends on residual AADC activity in surviving nigrostriatal neurons[@lerner2020].
Primary Expression	the substantia nigra pars compacta (SNc), ventral tegmental area (VTA), locus coeruleus, and raphe nuclei—regions critical for movement control, rewar
Molecular Weight	54 kDa
Amino Acids	466 aa
Pathways	NF-kB signaling, circadian regulation, glymphatic clearance, oxidative stress response
Ensembl ID	ENSG00000132437
GeneCards	DDC
Human Protein Atlas	DDC
Associated Diseases	Alzheimer's disease, Parkinson, Parkinson's Disease, als, alzheimer
Known Drugs/Compounds	levodopa
Interactions	GBA, LRRK2, MT1, TH, AQP4, APOE
SciDEX Hypotheses	Correcting Gut Microbial Dopamine Imbalance to Sup
KG Connections	116 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DDC["DDC"]
    Als["Als"]
    Parkinson["Parkinson"]
    AQP4["AQP4"]
    ALZHEIMER["ALZHEIMER"]
    Parkinson_s_disease["Parkinson's disease"]
    neurodegeneration["neurodegeneration"]
    DAT["DAT"]
    SUMF1["SUMF1"]
    GBA["GBA"]
    AADC["AADC"]
    PARKINSON["PARKINSON"]
    LRRK2["LRRK2"]
    GPR109A["GPR109A"]
    CHRNA7["CHRNA7"]
    AGER["AGER"]
    CSGA["CSGA"]
    Genes["Genes"]
    DDC -->|"biomarker_for"| Als
    DDC -->|"biomarker_for"| Parkinson
    AQP4 -.-|"associated"| DDC
    ALZHEIMER -.-|"associated"| DDC
    DDC -->|"biomarker_for"| Parkinson_s_disease
    DDC -->|"studied_in"| neurodegeneration
    DDC -->|"biomarker_for"| DAT
    DDC -->|"biomarker_for"| SUMF1
    DDC -->|"biomarker_for"| GBA
    DDC -->|"biomarker_for"| AADC
    DDC -->|"biomarker_for"| PARKINSON
    DDC -->|"biomarker_for"| LRRK2
    DDC -->|"activates"| GBA
    DDC -->|"activates"| LRRK2
    DDC -.-|"associated"| neurodegeneration
    DDC -.-|"discussed with"| GPR109A
    DDC -.-|"discussed with"| CHRNA7
    DDC -.-|"discussed with"| AGER
    DDC -.-|"discussed with"| CSGA
    Genes -->|"references"| DDC
    style DDC fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (82)

Target	Relation	Type	Str
Dementia with Lewy Bodies	biomarker_for	disease	0.95
dopamine biosynthesis	involved_in	process	0.95
Parkinson's Disease	biomarker_for	disease	0.92
PARKINSON'S DISEASE	treats	disease	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
TH	associated_with	gene	0.70
spinal muscular atrophy	biomarker_for	disease	0.70
neurons	regulates	cell_type	0.70
TAU	treats	protein	0.65
Als	biomarker_for	disease	0.65
Parkinson	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
SUMF1	biomarker_for	gene	0.60
GBA	biomarker_for	gene	0.60
AADC	biomarker_for	gene	0.60
LRRK2	biomarker_for	gene	0.60
GBA	activates	gene	0.60
LRRK2	activates	gene	0.60
Rb	biomarker_for	protein	0.60
GBA	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
L-DOPA	converts	drug	0.60
serotonin	inhibits	neurotransmitter	0.60
serotonin	upstream_of	neurotransmitter	0.60
TH	regulates	gene	0.60
TH	transported_by	gene	0.60
dementia with Lewy bodies	treats	disease	0.60
dementia with Lewy bodies	biomarker_for	disease	0.60
dementia with Lewy bodies	regulates	disease	0.60
dementia with Lewy bodies	colocalizes_in	disease	0.60
substantia nigra	expressed_in	brain_region	0.60
TH	interacts_with	gene	0.60
DRD1	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
Parkinson's disease	biomarker_for	disease	0.60
DAT	biomarker_for	gene	0.60
PARKINSON	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
PARKINSON'S DISEASE	biomarker_for	gene	0.60
App	biomarker_for	protein	0.60
oxidative stress response	participates_in	pathway	0.60
DOPAMINE	converts	phenotype	0.60
neurons	protects_against	cell_type	0.60
Parkinson's disease	treats	disease	0.60
spinal muscular atrophy	treats	disease	0.60
spinal muscular atrophy	regulates	disease	0.60
dementia	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Alzheimer's disease	regulates	disease	0.60
MAO	associated_with	gene	0.60

Incoming (34)

Source	Relation	Type	Str
h-d3a64f5c	targets_gene	hypothesis	0.90
SNCA	interacts_with	protein	0.85
TH	interacts_with	gene	0.70
Alzheimer's Disease	associated_with	disease	0.70
AQP4	associated_with	gene	0.65
ALZHEIMER	associated_with	gene	0.65
LRRK2	biomarker_for	gene	0.60
AADC	biomarker_for	gene	0.60
SUMF1	biomarker_for	gene	0.60
GBA	biomarker_for	gene	0.60
levodopa	inhibits	compound	0.60
levodopa	upstream_of	compound	0.60
APOE	associated_with	gene	0.60
APOE	interacts_with	gene	0.60
COMT	associated_with	gene	0.60
GBA MUTATIONS	biomarker_for	gene	0.60
PARKINSON	biomarker_for	gene	0.60
DAT	biomarker_for	gene	0.60
DAT	regulates	gene	0.60
AQP4	activates	gene	0.55
AQP4	co_mentioned	gene	0.55
levodopa	targets	drug	0.55
L-DOPA	associated_with	drug	0.50
MELATONIN	associated_with	drug	0.50
LEVODOPA	associated_with	drug	0.50
DEMENTIA	associated_with	disease	0.50
AGER	debate_co_mention	gene	0.45
CHRNA7	debate_co_mention	gene	0.45
CSGA	debate_co_mention	gene	0.45
PARKINSON	associated_with	disease	0.45
TDC	co_discussed	gene	0.40
TLR4	co_discussed	gene	0.40
AADC	co_mentioned	gene	0.40
HDAC	co_discussed	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Correcting Gut Microbial Dopamine Imbalance to Support Syste	0.412	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617

Related Papers (9)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Striatal Dysregulation of Angpt2 and Circadian Gene Expression in a Rotenone Rat [PMID:41925987]	Al Saeedy DY, Hawkins E, Dozmorov MG, Tr	J Mol Neurosci	2026
A quantitative DOPA decarboxylase biomarker for diagnosis in Lewy body disorders [PMID:41699128]	["Bolsewig K", "Bellomo G", "Hok-A-Hin Y	Nature medicine	2026
Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by [PMID:39881147]	["Bolsewig K", "Willemse E", "S\u00e1nch	Nature communications	2025
Characterization of Vps13b-mutant mice reveals neuroanatomical and behavioral ph [PMID:37573958]	["Montillot C", "Skutunova E", "Ayushma"	Neurobiology of disease	2023
Interplay between the catecholaminergic enzymatic axis and neurodegeneration/neu [PMID:36692274]	["Motta C", "Assogna M", "Bonomi C", "Di	European journal of neurology	2023
Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425]	Lieberwirth JK, Joset P, Heinze A, Hents	European journal of human gene	2021
Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174]	Liu J, Xie J	International journal of envir	2020
Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582]	Karas M, Marinsek N, Goldhahn J, Foschin	Digital biomarkers	2020
DOPA Decarboxylase Modulates Tau Toxicity. [PMID:28751068]	["Kow R", "Sikkema C", "Wheeler J", "Wil	Biological psychiatry	2018

DDC

Understanding Entity Pages

Wiki Pages (21)

DDC Gene

Locus Coeruleus Alpha Neurons

Dopamine Signaling Pathway

lmx1b

PITX3 Protein

Dopamine Pathway

Serotonin Signaling Pathway in Neurodegeneration

Korean Biotech Companies in Neurodegeneration

FOXA2 — Forkhead Box A2

Neuromelanin Synthesis

Amino Acid Supplementation in Parkinson's Disease

pharmacogenomics-cbs-psp

Dopamine Metabolism in PD

Selective Neuronal Vulnerability in Corticobasal Syndrome

Dopaminergic Substantia Nigra Neurons in Parkinson's Disease

Substantia Nigra Pars Compacta (SNc)

levodopa

Serotonin Signaling Pathway

COMT Inhibitors

SATB2 - Special AT-Rich Sequence Binding Protein 2