concept

SUBSTANTIA NIGRA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SUBSTANTIA NIGRA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

731Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

SUBSTANTIA NIGRA is a concept in neurodegeneration research. Key relationships include: co discussed, associated with, regulates. Associated with PARKINSON, PARKINSON'S, PARKINSON'S DISEASE. Connected to 79 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SUBSTANTIA NIGRA
Key Genes/Proteins	PARKIN, NF-KB, TNF, BDNF, TFEB
Related Diseases	PARKINSON'S DISEASE, STROKE, AUTOPHAGY

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SUBSTANTIA_NIGRA["SUBSTANTIA NIGRA"]
    SUBSTANTIA_NIGRA -->|"interacts"| Dopamine["Dopamine"]
    dopaminergic_neurons["dopaminergic neurons"] -->|"expressed in"| SUBSTANTIA_NIGRA
    Dopamine -->|"interacts"| SUBSTANTIA_NIGRA
    lipopolysaccharide["lipopolysaccharide"] -->|"activates"| SUBSTANTIA_NIGRA
    GCASE["GCASE"] -->|"expressed in"| SUBSTANTIA_NIGRA
    NEURON["NEURON"] -->|"expressed in"| SUBSTANTIA_NIGRA
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"expressed in"| SUBSTANTIA_NIGRA
    PARKINSON["PARKINSON"] -->|"expressed in"| SUBSTANTIA_NIGRA
    PLIN2["PLIN2"] -->|"expressed in"| SUBSTANTIA_NIGRA
    NEURODEGENERATION["NEURODEGENERATION"] -->|"expressed in"| SUBSTANTIA_NIGRA
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"expressed in"| SUBSTANTIA_NIGRA

Outgoing (154)

Target	Relation	Type	Str
L-DOPA	inhibits	drug	0.70
STROKE	regulates	disease	0.70
DOPAMINERGIC NEURONS	stabilizes	cell_type	0.70
GLIOSIS	inhibits	phenotype	0.65
PARKINSON'S DISEASE	treats	disease	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
TH	causes	gene	0.65
BASAL GANGLIA	causes	brain_region	0.65
GLIOSIS	interacts_with	phenotype	0.65
NEURODEGENERATION	activates	disease	0.65
UBIQUITIN	transports	protein	0.65
SYNAPTIC PLASTICITY	regulates	phenotype	0.65
TH	regulates	gene	0.60
THALAMUS	co_discussed	entity	0.50
TNF	co_discussed	entity	0.50
TREM2	co_discussed	entity	0.50
VENTRAL TEGMENTAL AREA	activates	brain_region	0.50
DEMENTIA	associated_with	disease	0.50
APP	associated_with	gene	0.50
EXCITOTOXICITY	associated_with	phenotype	0.50
ULK1	associated_with	gene	0.50
L-DOPA	associated_with	drug	0.50
AMPK SIGNALING	associated_with	pathway	0.50
ASTROCYTE	associated_with	cell_type	0.50
CYTOKINES	associated_with	phenotype	0.50
GLUTAMATE	associated_with	phenotype	0.50
STROKE	associated_with	disease	0.50
AMPK	associated_with	gene	0.50
GDNF	associated_with	gene	0.50
ROS	associated_with	phenotype	0.50
TET2	associated_with	gene	0.50
MACROPHAGE	associated_with	cell_type	0.50
AMYLOID	associated_with	protein	0.50
SIRT1	associated_with	gene	0.50
TFEB	associated_with	gene	0.50
TLR4	associated_with	gene	0.50
METFORMIN	associated_with	drug	0.50
NICOTINAMIDE	associated_with	drug	0.50
CELL DEATH	associated_with	phenotype	0.50
CURCUMIN	associated_with	drug	0.50
GLIOSIS	associated_with	phenotype	0.50
LAG3	associated_with	gene	0.50
CSF	associated_with	phenotype	0.50
LACTATE	associated_with	phenotype	0.50
CHLOROQUINE	associated_with	drug	0.45
RAPAMYCIN	associated_with	drug	0.45
SQSTM1	associated_with	gene	0.45
NLRP3	associated_with	gene	0.45
BECN1	associated_with	gene	0.45
CASP1	associated_with	gene	0.45

Incoming (577)

Source	Relation	Type	Str
PARKINSON'S DISEASE	associated_with	disease	1.00
MICROGLIA	associated_with	cell_type	1.00
DOPAMINERGIC NEURONS	expressed_in	entity	0.95
DOPAMINERGIC NEURONS	depletes	cell_type	0.95
PARKINSON'S DISEASE	depletes	disease	0.95
DOPAMINERGIC NEURONS	causes	cell_type	0.95
PARKIN	associated_with	gene	0.82
NF-KB	associated_with	protein	0.74
TNF	associated_with	gene	0.74
AUTOPHAGY	causes	phenotype	0.70
BDNF	protects_against	gene	0.70
TFEB	protects_against	gene	0.70
TFEB	regulates	gene	0.70
PARKINSON'S DISEASE	causes	disease	0.66
IL-1B	associated_with	gene	0.66
MTOR	associated_with	gene	0.66
ASTROCYTES	associated_with	cell_type	0.66
TREM2	associated_with	gene	0.66
AUTOPHAGY	inhibits	process	0.66
DOPAMINERGIC	reduces	cell_type	0.65
NEURON	reduces	cell_type	0.65
NEURONS	reduces	cell_type	0.65
STRIATUM	increases	brain_region	0.65
AKT	activates	gene	0.65
MTOR	activates	gene	0.65
PI3K	activates	gene	0.65
STRIATUM	expressed_in	brain_region	0.65
NEURON	sensitizes_to	cell_type	0.65
NEURONS	sensitizes_to	cell_type	0.65
PARKIN	sensitizes_to	gene	0.65
PARKINSON	sensitizes_to	disease	0.65
PARKINSON'S	sensitizes_to	disease	0.65
PARKINSON'S DISEASE	sensitizes_to	disease	0.65
DOPAMINERGIC	accumulates_in	cell_type	0.65
NEURON	accumulates_in	cell_type	0.65
DOPAMINERGIC	associated_with	cell_type	0.65
PARKIN	reduces	gene	0.65
PARKINSON	reduces	disease	0.65
PARKINSON'S	reduces	disease	0.65
PARKINSON'S DISEASE	reduces	disease	0.65
NEURON	inhibits	cell_type	0.65
ALPHA-SYNUCLEIN	causes	gene	0.65
PARKINSON'S DISEASE	implicated_in	disease	0.65
DOPAMINERGIC NEURONS	contributes_to	cell_type	0.65
ALPHA-SYNUCLEIN	contributes_to	gene	0.65
DOPAMINERGIC NEURONS	activates	cell_type	0.65
NEURON	implicated_in	cell_type	0.65
PARKIN	activates	gene	0.65
PREFRONTAL CORTEX	causes	brain_region	0.65
NEURON	treats	cell_type	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SUBSTANTIA NIGRA

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Parkinson's Disease

CBS/PSP Supplements Guide

Atypical Parkinsonism

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

NPM1 Gene

PI-2620 Tau PET in PSP

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Neurons — Cell Type Hierarchy