concept

DONEPEZIL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DONEPEZIL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

100Connections

0Hypotheses

0Analyses

41Outgoing

19Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	DONEPEZIL
Key Genes/Proteins	PP2A, CHRNA7, TAU, AKT
Related Diseases	NEUROINFLAMMATION, CYTOKINES
Related Pathways	AMPK

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DONEPEZIL["DONEPEZIL"]
    DONEPEZIL -->|"inhibits"| oxidative_stress["oxidative stress"]
    DONEPEZIL -->|"activates"| PP2A["PP2A"]
    DONEPEZIL -->|"binds"| LRPPRC["LRPPRC"]
    DONEPEZIL -->|"inhibits"| Acetylcholine["Acetylcholine"]
    DONEPEZIL -->|"inhibits"| MAPK["MAPK"]
    DONEPEZIL -->|"inhibits"| NF_kB["NF-kB"]
    DONEPEZIL -->|"inhibits"| NLRP3["NLRP3"]
    DONEPEZIL -->|"treats"| Alzheimer_s_disease["Alzheimer's disease"]
    Chinese_herbal_medicine["Chinese herbal medicine"] -->|"interacts"| DONEPEZIL
    CHRNA7["CHRNA7"] -->|"indirectly_activated_by"| DONEPEZIL
    AMPK["AMPK"] -->|"activates"| DONEPEZIL

Outgoing (78)

Target	Relation	Type	Str
AMPK	activates	pathway	0.80
PP2A	activates	gene	0.80
NEUROINFLAMMATION	activates	phenotype	0.70
NEUROINFLAMMATION	regulates	phenotype	0.70
NEURON	activates	cell_type	0.65
NEURON	phosphorylates	cell_type	0.65
TAU	phosphorylates	gene	0.65
MEMANTINE	promotes	drug	0.65
NEURON	promotes	cell_type	0.65
NEURONS	promotes	cell_type	0.65
NEURONS	activates	cell_type	0.65
CYTOKINES	activates	phenotype	0.65
AKT	activates	gene	0.65
NEUROINFLAMMATION	inhibits	phenotype	0.65
COGNITIVE DECLINE	degrades	phenotype	0.65
MICROGLIAL ACTIVATION	inhibits	phenotype	0.65
MICROGLIAL ACTIVATION	activates	phenotype	0.65
ALZHEIMER	associated_with	disease	0.50
NLRP3	associated_with	gene	0.50
STAT3	associated_with	gene	0.50
MAPK	associated_with	gene	0.50
AMPK	associated_with	gene	0.45
TAU	associated_with	protein	0.45
MEMANTINE	associated_with	drug	0.45
GLUTAMATE	associated_with	phenotype	0.45
NEURONS	associated_with	cell_type	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
RESVERATROL	associated_with	drug	0.45
EXCITOTOXICITY	associated_with	phenotype	0.45
GALANTAMINE	associated_with	drug	0.45
RIVASTIGMINE	associated_with	drug	0.45
CYTOKINES	associated_with	phenotype	0.45
AKT	associated_with	gene	0.45
APP	associated_with	gene	0.45
DONANEMAB	associated_with	drug	0.45
OXIDATIVE STRESS	activates	process	0.35
RESVERATROL	activates	drug	0.35
TAU	activates	protein	0.35
EXCITOTOXICITY	activates	process	0.35
MEMANTINE	activates	drug	0.35
ad_clinical_trial_failures:donepezil	data_in	dataset_row	0.00

Incoming (22)

Source	Relation	Type	Str
CHRNA7	indirectly_activated_by	gene	0.70
CHOLINERGIC	promotes	cell_type	0.65
APP	treats	gene	0.65
APP	regulates	gene	0.65
ALZHEIMER'S DISEASE	associated_with	disease	0.50
NEUROINFLAMMATION	associated_with	phenotype	0.50
OXIDATIVE STRESS	associated_with	phenotype	0.45
AMPK PATHWAY	associated_with	pathway	0.45
RESVERATROL	associated_with	drug	0.45
EXCITOTOXICITY	associated_with	phenotype	0.45
RIVASTIGMINE	associated_with	drug	0.45
GALANTAMINE	associated_with	drug	0.45
AMPK	associated_with	gene	0.45
GLUTAMATE EXCITOTOXICITY	associated_with	phenotype	0.45
ASTROCYTES	associated_with	cell_type	0.45
COGNITIVE DECLINE	associated_with	phenotype	0.45
MICROGLIAL ACTIVATION	associated_with	phenotype	0.45
AMPK	activates	gene	0.35
ad_clinical_trial_failures:donepezil	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DONEPEZIL

Understanding Entity Pages

Wiki Pages (20)

Clinical Management Guide for CBS/PSP

Corticobasal Syndrome (CBS)

calcium-dysregulation-comparison

Therapeutics

CBS/PSP Treatment Rankings

Alzheimer's Disease

APOC4 — Apolipoprotein C-IV

Huntington's Disease

Vascular Cognitive Impairment (VCI)

A Phase 3, Randomised, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy, Tolerability, and Safety of Combined Metabolic Activator Supplementation in Subjects Diagnosed With Alzheimer's Disease

cognitive-reserve-cbs-psp

Excitotoxicity in Neurodegeneration

Synucleinopathies

Protein Aggregation Comparison in Neurodegeneration

KarXT for Alzheimer's Disease Cognitive Impairment - MINDSET 2 (NCT06976203)

Pedunculopontine Nucleus Cholinergic Neurons in Neurodegeneration

Benfotiamine Phase 2 Alzheimer's Disease Trial (NCT06223360)

Bepranemab (UCB0107)

APP Flemish Mutation (APP Flemish)