entity

nicotinic receptor

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about nicotinic receptor: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

11Outgoing

32Incoming

Wiki Pages (20)

Knowledge base pages for this entity

Outgoing (11)

Target	Relation	Type	Str
neurons	expressed_in	cell_type	0.90
cortex	expressed_in	brain_region	0.80
unfolded protein response	activates	pathway	0.70
synaptic plasticity	activates	pathway	0.70
interneurons	expressed_in	cell_type	0.60
glutamate signaling	activates	pathway	0.60
prefrontal cortex	expressed_in	brain_region	0.60
oligodendrocytes	expressed_in	cell_type	0.60
T cells	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60
pyroptosis	activates	pathway	0.60

Incoming (32)

Source	Relation	Type	Str
CHRNA7	expressed_in	gene	0.80
neurodegeneration	involves	disease	0.80
Alzheimer's disease	involves	disease	0.80
depression	involves	disease	0.70
schizophrenia	involves	disease	0.70
CHRNA7	implicated_in	gene	0.70
HMGB1	activates	gene	0.60
RAGE	activates	gene	0.60
HMGB1	expressed_in	gene	0.60
RAGE	expressed_in	gene	0.60
HMGB1	promotes	gene	0.60
neuropathic pain	involves	disease	0.60
donepezil	activates	compound	0.60
donepezil	protects_against	compound	0.60
CHRNA7	regulates	gene	0.60
CHRNA7	associated_with	gene	0.60
APP	modulates	gene	0.60
APP	activates	gene	0.60
APP	regulates	gene	0.60
NLRP3	activates	gene	0.60
stroke	involves	disease	0.60
NLRP3	protects_against	gene	0.60
neuroinflammation	involves	disease	0.60
NLRP3	inhibits	gene	0.60
DRD2	regulates	gene	0.60
DRD2	interacts_with	gene	0.60
ERK	associated_with	gene	0.60
RNA	regulates	gene	0.60
MAPK	activates	gene	0.60
multiple sclerosis	involves	disease	0.60
YAP	regulates	gene	0.60
YAP	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

nicotinic receptor

Understanding Entity Pages

Wiki Pages (20)

ventral-anterior-thalamic-nucleus

Hypera Pharma

visual-cortex-layer-2-3-neurons

Kynurenine Pathway Dysregulation in 4R-Tauopathies

Ion Channel Dysfunction in Alzheimer's Disease

Lateropontine Nucleus Neurons

gut-brain-axis-tauopathy

Neurons

Calcium Signaling Dysregulation in Alzheimer's Disease

Synaptic Loss and Dysfunction Pathway

CHRNB2 Protein — Nicotinic Receptor Beta 2 Subunit

CHRNB3 Gene

Dementia with Lewy Bodies (DLB)

rivastigmine

Dopaminergic Neurons (SNpc)

Vascular Risk Factors in Alzheimer's Disease

EX039 Phase 2 (NCT05413655) — Oral Therapeutic for Alzheimer's Disease

Section 244: Advanced Autophagy Induction and TFEB Activation in CBS/PSP

Striatal Cholinergic Interneurons

donepezil

Outgoing (11)

Incoming (32)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)