concept

NICOTINIC RECEPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NICOTINIC RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

42Connections

3Hypotheses

0Analyses

11Outgoing

31Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	NICOTINIC RECEPTOR

Pathway Diagram

graph TD
    NICOTINIC_RECEPTOR[NICOTINIC RECEPTOR]
    NICOTINIC_RECEPTOR -->|expressed in| neurons[neurons]
    NICOTINIC_RECEPTOR -->|expressed in| cortex[cortex]
    NICOTINIC_RECEPTOR -->|activates| unfolded_protein_response[unfolded protein response]
    NICOTINIC_RECEPTOR -->|activates| synaptic_plasticity[synaptic plasticity]
    NICOTINIC_RECEPTOR -->|expressed in| interneurons[interneurons]
    NICOTINIC_RECEPTOR -->|activates| glutamate_signaling[glutamate signaling]
    NICOTINIC_RECEPTOR -->|expressed in| prefrontal_cortex[prefrontal cortex]
    NICOTINIC_RECEPTOR -->|expressed in| oligodendrocytes[oligodendrocytes]
    NICOTINIC_RECEPTOR -->|expressed in| T_cells[T cells]
    NICOTINIC_RECEPTOR -->|expressed in| microglia[microglia]
    CHRNA7[CHRNA7] -->|expressed in| NICOTINIC_RECEPTOR
    neurodegeneration[neurodegeneration] -->|involves| NICOTINIC_RECEPTOR
    Alzheimer_s_disease[Alzheimer's disease] -->|involves| NICOTINIC_RECEPTOR
    depression[depression] -->|involves| NICOTINIC_RECEPTOR
    schizophrenia[schizophrenia] -->|involves| NICOTINIC_RECEPTOR
    HMGB1[HMGB1] -->|activates| NICOTINIC_RECEPTOR
    RAGE[RAGE] -->|activates| NICOTINIC_RECEPTOR

Outgoing (11)

Target	Relation	Type	Str
neurons	expressed_in	cell_type	0.90
cortex	expressed_in	brain_region	0.80
synaptic plasticity	activates	pathway	0.70
unfolded protein response	activates	pathway	0.70
oligodendrocytes	expressed_in	cell_type	0.60
T cells	expressed_in	cell_type	0.60
microglia	expressed_in	cell_type	0.60
pyroptosis	activates	pathway	0.60
interneurons	expressed_in	cell_type	0.60
glutamate signaling	activates	pathway	0.60
prefrontal cortex	expressed_in	brain_region	0.60

Incoming (31)

Source	Relation	Type	Str
Alzheimer's disease	involves	disease	0.80
neurodegeneration	involves	disease	0.80
CHRNA7	expressed_in	gene	0.80
CHRNA7	associated_with	gene	0.70
schizophrenia	involves	disease	0.70
depression	involves	disease	0.70
HMGB1	activates	gene	0.60
RAGE	activates	gene	0.60
HMGB1	expressed_in	gene	0.60
RAGE	expressed_in	gene	0.60
HMGB1	promotes	gene	0.60
ERK	associated_with	gene	0.60
RNA	regulates	gene	0.60
MAPK	activates	gene	0.60
multiple sclerosis	involves	disease	0.60
CHRNA7	regulates	gene	0.60
APP	modulates	gene	0.60
APP	activates	gene	0.60
APP	regulates	gene	0.60
NLRP3	activates	gene	0.60
stroke	involves	disease	0.60
NLRP3	protects_against	gene	0.60
neuroinflammation	involves	disease	0.60
NLRP3	inhibits	gene	0.60
DRD2	regulates	gene	0.60
DRD2	interacts_with	gene	0.60
YAP	regulates	gene	0.60
YAP	interacts_with	gene	0.60
neuropathic pain	involves	disease	0.60
donepezil	activates	compound	0.60
donepezil	protects_against	compound	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Amyloid first impairs cholinergic terminals through alpha7 n	0.450	neurodegeneration	What determines the temporal sequence of
Nicotinic Receptor-Lipid Raft Co-Modulators	0.000	-	Lipid raft composition changes in synapt
Cholinergic Modulation via α7 Nicotinic Receptors	0.000	-	Selective vulnerability of entorhinal co

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NICOTINIC RECEPTOR in their description or question text

No additional research found