concept

LIPID PEROXIDATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIPID PEROXIDATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

138Connections

1Hypotheses

0Analyses

43Outgoing

41Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	LIPID PEROXIDATION
Key Genes/Proteins	TH, HMGCR, GPX4, ACSL4, UBIQUITIN
Related Diseases	OXIDATIVE STRESS, NEUROINFLAMMATION, SENESCENCE, GLUTAMATE, FERROPTOSIS
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LIPID_PEROXIDATION["LIPID PEROXIDATION"]
    LIPID_PEROXIDATION -->|"involved_in"| Ferroptosis["Ferroptosis"]
    LIPID_PEROXIDATION -->|"causes"| Cellular_Membrane_Destruction["Cellular Membrane Destruction"]
    LIPID_PEROXIDATION -->|"causes"| Ferroptotic_Cell_Death["Ferroptotic Cell Death"]
    LIPID_PEROXIDATION -->|"causes"| Lysosomal_Damage["Lysosomal Damage"]
    LIPID_PEROXIDATION -->|"causes"| Lipofuscinosis["Lipofuscinosis"]
    NADPH["NADPH"] -->|"inhibits"| LIPID_PEROXIDATION
    Ferroptosis -->|"mediates"| LIPID_PEROXIDATION
    ZnONPs["ZnONPs"] -->|"causes"| LIPID_PEROXIDATION
    GPX4["GPX4"] -->|"inhibits"| LIPID_PEROXIDATION
    Ferrostatin_1["Ferrostatin-1"] -->|"inhibits"| LIPID_PEROXIDATION
    AMPK["AMPK"] -->|"inhibits"| LIPID_PEROXIDATION

Outgoing (61)

Target	Relation	Type	Str
OXIDATIVE STRESS	activates	phenotype	0.70
NEUROINFLAMMATION	inhibits	phenotype	0.70
HMGCR	treats	gene	0.65
GLUTAMATE	inhibits	phenotype	0.65
FERROPTOSIS	protects_against	phenotype	0.65
NEURONS	treats	cell_type	0.65
ROS	treats	phenotype	0.65
GPX4	regulates	gene	0.65
ACSL4	activates	gene	0.65
ACSL4	regulates	gene	0.65
GPX4	causes	gene	0.65
UBIQUITIN	activates	protein	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
OXIDATIVE STRESS	biomarker_for	phenotype	0.65
OXIDATIVE STRESS	inhibits	phenotype	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
NEUROINFLAMMATION	regulates	phenotype	0.65
ATP	regulates	phenotype	0.65
FERROPTOSIS	treats	phenotype	0.65
INSULIN RESISTANCE	treats	phenotype	0.65
ALZHEIMER'S DISEASE	degrades	disease	0.65
MICROGLIAL ACTIVATION	regulates	phenotype	0.65
APOPTOSIS	inhibits	phenotype	0.65
TAU	phosphorylates	protein	0.65
CALCIUM SIGNALING	protects_against	pathway	0.65
NEURONS	protects_against	cell_type	0.65
NEURONS	activates	cell_type	0.65
NEURODEGENERATION	implicated_in	disease	0.55
ALZHEIMER'S DISEASE	implicated_in	disease	0.55
NEURODEGENERATION	participates_in	disease	0.55
QUERCETIN	associated_with	drug	0.50
WHITE MATTER	associated_with	brain_region	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
CORTEX	associated_with	brain_region	0.50
NICOTINAMIDE	associated_with	drug	0.45
KAEMPFEROL	associated_with	drug	0.45
SUBSTANTIA NIGRA	associated_with	brain_region	0.45
BRAINSTEM	associated_with	brain_region	0.45
DEFEROXAMINE	associated_with	drug	0.45
STRIATUM	associated_with	brain_region	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
CALCIUM SIGNALING	associated_with	pathway	0.45

Incoming (77)

Source	Relation	Type	Str
TH	activates	gene	0.70
SENESCENCE	regulates	phenotype	0.70
WHITE MATTER	causes	brain_region	0.70
CELL DEATH	causes	phenotype	0.65
BECN1	treats	gene	0.65
BECN1	activates	gene	0.65
APOE	interacts_with	gene	0.65
GPX4	treats	gene	0.65
CELL DEATH	activates	phenotype	0.65
GPX4	activates	gene	0.65
FERROPTOSIS	inhibits	phenotype	0.65
CELL DEATH	regulates	phenotype	0.65
FERROPTOSIS	regulates	phenotype	0.65
GPX4	exacerbates	gene	0.65
SEPSIS	targets	disease	0.65
SEPSIS	regulates	disease	0.65
ATG5	causes	gene	0.65
ATG5	activates	gene	0.65
NEURONS	causes	cell_type	0.65
STROKE	causes	disease	0.65
STROKE	activates	disease	0.65
OXIDATIVE STRESS	exacerbates	phenotype	0.65
NRF2	regulates	gene	0.65
NRF2	activates	gene	0.65
KEAP1	inhibits	gene	0.65
KEAP1	activates	gene	0.65
DOPAMINE	causes	phenotype	0.65
TNF	phosphorylates	gene	0.65
DEFEROXAMINE	treats	drug	0.65
LRRK2	protects_against	gene	0.65
UBIQUITIN	inhibits	protein	0.65
APOE4	inhibits	gene	0.65
APOE4	interacts_with	gene	0.65
FERROPTOSIS	degrades	phenotype	0.65
OXIDATIVE STRESS	interacts_with	phenotype	0.65
KYNURENINE	causes	phenotype	0.65
ASTROCYTE	causes	cell_type	0.65
NRF2	inhibits	gene	0.65
TH	depleted_in	gene	0.60
SENESCENCE	activates	phenotype	0.60
SENESCENCE	synergizes_with	phenotype	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Senescence-Induced Lipid Peroxidation Spreading	0.533	neurodegeneration	Senolytic therapy for age-related neurod

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (18)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Klebsiella pneumoniae Induces Ferroptosis and Lactation Dysfunction in Bovine Ma [PMID:40937759]	Mao P, Wang Z, Duan J, Dong P, Yuan C, L	J Agric Food Chem	2025	1
Targeting ferroptosis: novel therapeutic approaches and intervention strategies [PMID:41425591]	Luo Y, Long M, Wu X, Zeng L	Front Immunol	2025	1
Trimetazidine attenuates Ischemia/Reperfusion-Induced myocardial ferroptosis by [PMID:39134283]	Tan M, Yin Y, Chen W, Zhang J, Jin Y, Zh	Biochem Pharmacol	2024	1
Discovery of a glycosylated colchicine derivative as a neuroprotective agent for [PMID:41455281]	["Jash M", "Gupta S", "Garg S", "Khan J"	European journal of medicinal	2026	0
The NADPH oxidase inhibitor Vas2870 prevents myocyte ferroptosis and improves ca [PMID:41671579]	Wang J, Li CM, Yang B, Tantai RN, Guo HX	British journal of pharmacolog	2026	0
From association to mechanism: Prenatal PFAS Co-exposures induces fetal neural t [PMID:41485332]	Chen Y, Cheng Q, Yang C, Li S, Lin H, Li	Journal of hazardous materials	2026	0
Silencing myeloid cell leukemia-1 improves apoptotic and ferroptotic responses i [PMID:41540498]	Fang F, Xu Q, Shen S, Wang S, Bao C	European journal of medical re	2026	0
Traditional Chinese Herbal Formula XuMingZhuSan Alleviates Neuronal Ferroptosis [PMID:41822239]	Liu X, Wang C, Han L, Xiao Y, Yu H, Hu Z	Food science & nutrition	2026	0
Psoraleae Fructus combined with Walnut kernels improves postmenopausal osteoporo [PMID:41016294]	["Hu L", "Luo M", "Zhu X", "Wang Z", "Ya	Phytomedicine : international	2025	0
Polystyrene microplastics induced spermatogenesis disorder via disrupting mitoch [PMID:39577614]	["Jin H", "Xue B", "Chen X", "Ma T", "Ma	Environmental pollution (Barki	2025	0
Yi-Nao-Jie-Yu Prescription Relieves Post-Stroke Depression by Mitigating Ferropt [PMID:40214929]	["Zhang Y", "Tang Q", "Yao J", "Liu H",	Journal of neuroimmune pharmac	2025	0
Light-triggered carbon monoxide-induced activation of enhanced ferritinophagy-me [PMID:41080723]	["Liu Q", "Zhang J", "Yu L", "Chen Y", "	Materials today. Bio	2025	0
Triptolide induces hepatotoxicity by promoting ferroptosis through Nrf2 degradat [PMID:39503881]	["Guo L", "Yang Y", "Ma J", "Xiao M", "C	Cell biology and toxicology	2024	0
Mifepristone protects acetaminophen induced liver injury through NRF2/GSH/GST me [PMID:38906233]	["Shi Y", "Xu N", "Liu B", "Ma Y", "Fu X	Free radical biology & medicin	2024	0
Use of Deep-Learning Assisted Assessment of Cardiac Parameters in Zebrafish to D [PMID:37679058]	["Liu C", "Wang Y", "Zeng Y", "Kang Z",	Advanced science (Weinheim, Ba	2023	0
In Vivo Assessment of Ferroptosis and Ferroptotic Stress in Mice. [PMID:35384401]	["Ide K", "Souma T"]	Current protocols	2022	0
En masse DNA Electroporation for in vivo Transcriptional Assay in Ascidian Embry [PMID:34692910]	Darras S	Bio-protocol	2021	0
Management of primary aldosteronism and mineralocorticoid receptor-associated hy [PMID:32424201]	["Morimoto S", "Ichihara A"]	Hypertension research : offici	2020	0

LIPID PEROXIDATION

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Alpha-Synuclein Pathology

Alzheimer's Disease Mechanism Index

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

NRF2 Oxidative Stress Pathway

coq10-neurodegeneration

oxidative-stress-comparison

APOC4 — Apolipoprotein C-IV

omega-3-fatty-acids-neurodegeneration

Vascular Cognitive Impairment (VCI)

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

substantia-nigra

deferiprone-neurodegeneration

dimethyl-fumarate-nrf2-ad-nct06850597

A Phase 3, Randomised, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy, Tolerability, and Safety of Combined Metabolic Activator Supplementation in Subjects Diagnosed With Alzheimer's Disease