gene

GSR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

100Connections
0Hypotheses
0Analyses
50Outgoing
38Incoming

Summary

GSR is a gene implicated in neurodegeneration research. Key relationships include: regulates, inhibits, therapeutic target. Associated with ALS, Als, Alzheimer. Connected to 26 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolGSR
Full NameGlutathione Reductase
Chromosome8p12
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionall tissues
PathwaysEpigenetic
UniProt IDP16455
NCBI Gene ID2935
Ensembl IDENSG00000100647
GeneCardsGSR
Human Protein AtlasGSR
Glutathione (GSH/GSSG)Tripeptide antioxidant substrate and product
Glutathione Peroxidase (GPX)Enzyme utilizing GSH for hydrogen peroxide reduction
Superoxide Dismutase (SOD)Complementary antioxidant enzyme
Associated DiseasesALS
InteractionsCNO, GPX4, VDAC2, DMT1, CYBB, ATF4
KG Connections100 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: GSR — AlphaFold P16455 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

GSR — Glutathione Reductase

gene · 628 words

Golgi Apparatus Stress Comparison Across Neurodegenerative Diseases

mechanism · 3286 words

Reactive Oxygen Species (ROS) Pathway

mechanism · 3211 words

Glutathione Metabolism Pathway

mechanism · 3056 words

GSS Gene (Glutathione Synthetase)

gene · 2275 words

Shimmer

company · 2189 words

Pathway Diagram

graph TD
    GSR["<b>GSR</b>"]
    Dementia{"Dementia"}
    GSR -->|"therapeutic target"| Dementia
    Als{"Als"}
    GSR -->|"therapeutic target"| Als
    Anxiety{"Anxiety"}
    GSR -->|"therapeutic target"| Anxiety
    Alzheimer{"Alzheimer"}
    GSR -->|"therapeutic target"| Alzheimer
    Ms{"Ms"}
    GSR -->|"therapeutic target"| Ms
    GSR -->|"activates"| Als
    GSR -->|"activates"| Anxiety
    GSR -->|"activates"| Dementia
    GSR -->|"regulates"| Als
    GSR -->|"regulates"| Ms
    ALS{"ALS"}
    GSR -->|"inhibits"| ALS
    GSR -->|"inhibits"| Anxiety
    CNO["CNO"]
    CNO -->|"therapeutic target"| GSR
    CNO -->|"activates"| GSR
    MFN1["MFN1"]
    MFN1 -->|"regulates"| GSR
    CDK1["CDK1"]
    CDK1 -->|"regulates"| GSR
    SOD1["SOD1"]
    SOD1 -->|"regulates"| GSR
    ANTIOXIDANT_GENES["ANTIOXIDANT GENES"]
    ANTIOXIDANT_GENES -->|"regulates"| GSR
    CAT["CAT"]
    CAT -->|"regulates"| GSR
    style GSR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (62)

TargetRelationTypeStr
Lipid Peroxidationinhibitsprocess0.90
Dementiatherapeutic_targetdisease0.65
Alstherapeutic_targetdisease0.65
Anxietytherapeutic_targetdisease0.65
Alzheimertherapeutic_targetdisease0.65

Incoming (38)

SourceRelationTypeStr
CNOtherapeutic_targetgene0.60
CNOactivatesgene0.60
MFN1regulatesgene0.60
CDK1regulatesgene0.60
SOD1regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found