Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GSR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GSR is a gene implicated in neurodegeneration research. Key relationships include: regulates, inhibits, therapeutic target. Associated with ALS, Als, Alzheimer. Connected to 26 entities in the SciDEX knowledge graph.
| Gene Symbol | GSR |
| Full Name | Glutathione Reductase |
| Chromosome | 8p12 |
| Protein Type | Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | all tissues |
| Pathways | Epigenetic |
| UniProt ID | P16455 |
| NCBI Gene ID | 2935 |
| Ensembl ID | ENSG00000100647 |
| GeneCards | GSR |
| Human Protein Atlas | GSR |
| Glutathione (GSH/GSSG) | Tripeptide antioxidant substrate and product |
| Glutathione Peroxidase (GPX) | Enzyme utilizing GSH for hydrogen peroxide reduction |
| Superoxide Dismutase (SOD) | Complementary antioxidant enzyme |
| Associated Diseases | ALS |
| Interactions | CNO, GPX4, VDAC2, DMT1, CYBB, ATF4 |
| KG Connections | 100 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GSR["<b>GSR</b>"]
Dementia{"Dementia"}
GSR -->|"therapeutic target"| Dementia
Als{"Als"}
GSR -->|"therapeutic target"| Als
Anxiety{"Anxiety"}
GSR -->|"therapeutic target"| Anxiety
Alzheimer{"Alzheimer"}
GSR -->|"therapeutic target"| Alzheimer
Ms{"Ms"}
GSR -->|"therapeutic target"| Ms
GSR -->|"activates"| Als
GSR -->|"activates"| Anxiety
GSR -->|"activates"| Dementia
GSR -->|"regulates"| Als
GSR -->|"regulates"| Ms
ALS{"ALS"}
GSR -->|"inhibits"| ALS
GSR -->|"inhibits"| Anxiety
CNO["CNO"]
CNO -->|"therapeutic target"| GSR
CNO -->|"activates"| GSR
MFN1["MFN1"]
MFN1 -->|"regulates"| GSR
CDK1["CDK1"]
CDK1 -->|"regulates"| GSR
SOD1["SOD1"]
SOD1 -->|"regulates"| GSR
ANTIOXIDANT_GENES["ANTIOXIDANT GENES"]
ANTIOXIDANT_GENES -->|"regulates"| GSR
CAT["CAT"]
CAT -->|"regulates"| GSR
style GSR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Lipid Peroxidation | inhibits | process | 0.90 |
| Dementia | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Anxiety | therapeutic_target | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Anxiety | activates | disease | 0.65 |
| Dementia | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Anxiety | inhibits | disease | 0.65 |
| Dementia | inhibits | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| Ferroptosis | activates | disease | 0.65 |
| Diabetes | activates | disease | 0.65 |
| CNO | inhibits | gene | 0.60 |
| CNO | therapeutic_target | gene | 0.60 |
| GPX4 | inhibits | gene | 0.60 |
| VDAC2 | activates | gene | 0.60 |
| DMT1 | activates | gene | 0.60 |
| CYBB | activates | gene | 0.60 |
| ATF4 | inhibits | gene | 0.60 |
| Rb | therapeutic_target | protein | 0.60 |
| HIF1A | activates | gene | 0.60 |
| HUWE1 | activates | gene | 0.60 |
| IL1B | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| MUL1 | activates | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| OPA1 | activates | gene | 0.60 |
| PARL | activates | gene | 0.60 |
| PINK1 | activates | gene | 0.60 |
| PRKN | activates | gene | 0.60 |
| PTEN | activates | gene | 0.60 |
| SLC7A11 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| TXN | activates | gene | 0.60 |
| VCP | activates | gene | 0.60 |
| SOD1 | activates | gene | 0.60 |
| SOD1 | regulates | gene | 0.60 |
| Epigenetic | regulates | pathway | 0.60 |
| ANXIETY | inhibits | gene | 0.60 |
| DEMENTIA | inhibits | gene | 0.60 |
| AND | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| ANXIETY | therapeutic_target | gene | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CNO | therapeutic_target | gene | 0.60 |
| CNO | activates | gene | 0.60 |
| MFN1 | regulates | gene | 0.60 |
| CDK1 | regulates | gene | 0.60 |
| SOD1 | regulates | gene | 0.60 |
| CAT | regulates | gene | 0.60 |
| NRF2 | inhibits | gene | 0.60 |
| HMOX1 | activates | gene | 0.60 |
| APP | activates | gene | 0.60 |
| AMBRA1 | activates | gene | 0.60 |
| BAK1 | activates | gene | 0.60 |
| BAX | activates | gene | 0.60 |
| BCL2 | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| BNIP3 | activates | gene | 0.60 |
| BNIP3L | activates | gene | 0.60 |
| CASP1 | activates | gene | 0.60 |
| CAT | activates | gene | 0.60 |
| CNP | activates | gene | 0.60 |
| DNM1L | activates | gene | 0.60 |
| DRP1 | activates | gene | 0.60 |
| FUNDC1 | activates | gene | 0.60 |
| GSK3B | activates | gene | 0.60 |
| CAT | expressed_in | gene | 0.60 |
| ANTIOXIDANT GENES | regulates | gene | 0.60 |
| ANXIETY | inhibits | gene | 0.60 |
| DEMENTIA | inhibits | gene | 0.60 |
| ANXIETY | therapeutic_target | gene | 0.60 |
| DEMENTIA | therapeutic_target | gene | 0.60 |
| LPCAT3 | activates | gene | 0.60 |
| ROS | activates | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| G6PD | activates | gene | 0.60 |
| GSH | activates | gene | 0.60 |
| ATP | activates | gene | 0.60 |
| FUNDC1 | co_expressed_with | gene | 0.50 |
| GSK3B | co_expressed_with | gene | 0.50 |
| CNO | associated_with | gene | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||