concept

ZFP36

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ZFP36: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

152Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

ZFP36 is a concept in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Als, Alzheimer, Atherosclerosis. Connected to 119 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ZFP36
Key Genes/Proteins	TXNIP, ATG16L1, FBXW7, RNA
Related Diseases	Hypoxic-Ischemic Brain Damage, Carcinoma, Tumor
Related Pathways	Nlrp3 Inflammasome, ferroptosis, autophagy, Txnip/Nlrp3 Inflammasome Pathway

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ZFP36["ZFP36"]
    ZFP36 -.protects against.-> ferroptosis["ferroptosis"]
    ZFP36 -->|"inhibits"| ATG16L1["ATG16L1"]
    ZFP36 -->|"inhibits"| autophagy["autophagy"]
    ZFP36 -->|"interacts"| Ms["Ms"]
    ZFP36 -->|"expressed in"| Tumor["Tumor"]
    ZFP36 -->|"regulates"| Leukemia["Leukemia"]
    ZFP36 -->|"activates"| Inflammation["Inflammation"]
    ZFP36 -->|"activates"| Stroke["Stroke"]
    ZFP36 -->|"activates"| Als["Als"]
    FBXW7["FBXW7"] -->|"inhibits"| ZFP36
    DMSO["DMSO"] -->|"expressed in"| ZFP36
    TNF["TNF"] -->|"expressed in"| ZFP36
    BCL2["BCL2"] -->|"regulates"| ZFP36
    APOPTOSIS["APOPTOSIS"] -->|"regulates"| ZFP36
    ANXA2["ANXA2"] -->|"activates"| ZFP36
    ICAM1["ICAM1"] -->|"activates"| ZFP36
    CD44["CD44"] -->|"activates"| ZFP36
    HMOX1["HMOX1"] -->|"activates"| ZFP36
    SPP1["SPP1"] -->|"activates"| ZFP36

Outgoing (81)

Target	Relation	Type	Str
TXNIP	binds	gene	0.95
TXNIP	downregulates	gene	0.95
Nlrp3 Inflammasome	inhibits	pathway	0.95
Hypoxic-Ischemic Brain Damage	protects_against	disease	0.95
ferroptosis	protects_against	pathway	0.90
ATG16L1	inhibits	gene	0.90
autophagy	inhibits	pathway	0.90
Neuronal Apoptosis	inhibits	process	0.90
Pyroptosis	inhibits	process	0.90
Hippocampal Neurons	expressed_in	cell_type	0.85
Carcinoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Ms	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Leukemia	regulates	disease	0.65
Ms	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Ischemia	activates	disease	0.65
Ms	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Lymphoma	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Tumor	inhibits	disease	0.65
Hepatocellular Carcinoma	associated_with	disease	0.65
Sepsis	therapeutic_target	disease	0.65
FTH1	associated_with	gene	0.60
P62	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60
FBXW7	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
P53	associated_with	gene	0.60
TP53	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
Autophagy	interacts_with	pathway	0.60
Ferroptosis	regulates	pathway	0.60
IL12B	expressed_in	gene	0.60
Apoptosis	regulates	pathway	0.60
FERROPTOSIS	associated_with	gene	0.60
NOD2	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
NEAT1	regulates	gene	0.60
CTSD	associated_with	gene	0.60

Incoming (71)

Source	Relation	Type	Str
FBXW7	inhibits	gene	0.90
Txnip/Nlrp3 Inflammasome Pathway	therapeutic_target	pathway	0.90
RNA	interacts_with	gene	0.70
SQSTM1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
ELAVL1	associated_with	gene	0.60
GPX4	associated_with	gene	0.60
ATG	associated_with	gene	0.60
FN1	associated_with	gene	0.60
SLC7A11	associated_with	gene	0.60
DMSO	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
ZFP36L2	associated_with	gene	0.60
BCL2	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
PYCARD	associated_with	gene	0.60
HMOX1	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
NAMPT	associated_with	gene	0.60
ANXA2	activates	gene	0.60
ICAM1	activates	gene	0.60
CD44	activates	gene	0.60
HMOX1	activates	gene	0.60
SPP1	activates	gene	0.60
MICROGLIA	activates	gene	0.60
TIMP1	activates	gene	0.60
LGALS3	activates	gene	0.60
CD14	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
RGS1	activates	gene	0.60
ICAM1	therapeutic_target	gene	0.60
CXCL1	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
SOCS3	therapeutic_target	gene	0.60
IL6	therapeutic_target	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
C5AR1	expressed_in	gene	0.60
TNF	therapeutic_target	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
IL7R	inhibits	gene	0.60
TP53	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
BECN1	associated_with	gene	0.60
COL1A1	associated_with	gene	0.60
P62	associated_with	gene	0.60
MAP1LC3A	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ZFP36

Understanding Entity Pages

Summary

Wiki Pages (5)

ZFP36L2 — Zinc Finger Protein L2

Stress Granule-Associated Neurons

ENDOU — Endonuclease Poly(U) Polypeptide