concept

ACACA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACACA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

32Outgoing

9Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ACACA
Key Genes/Proteins	SREBF1, LDLR, SREBF2, FASN, LDL
Related Diseases	Lactation, Lactation Dysfunction, Als, Cancer, ALS
Related Pathways	Lipid Metabolism

Wiki Pages (2)

Knowledge base pages for this entity

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

gene · 1883 words

→

SREBP1 Protein (Sterol Regulatory Element-Binding Protein 1)

protein · 1058 words

→

Pathway Diagram

graph TD
    ACACA["ACACA"]
    ACACA -.biomarker for.-> Lactation_Dysfunction["Lactation Dysfunction"]
    ACACA -->|"regulates"| Als["Als"]
    ACACA -->|"regulates"| Cancer["Cancer"]
    ACACA -->|"regulates"| ALS["ALS"]
    ACACA -->|"contributes to"| SREBF1["SREBF1"]
    ACACA -->|"contributes to"| LDLR["LDLR"]
    ACACA -->|"contributes to"| SREBF2["SREBF2"]
    ACACA -->|"regulates"| FASN["FASN"]
    GENES["GENES"] -->|"contributes to"| ACACA
    LDL["LDL"] -->|"contributes to"| ACACA
    SREBF1 -->|"contributes to"| ACACA
    SREBF2 -->|"contributes to"| ACACA
    LDLR -->|"contributes to"| ACACA
    FASN -->|"regulates"| ACACA

Outgoing (32)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
triglyceride synthesis	involved_in	process	0.90
Lactation	involved_in	phenotype	0.85
Lactation Dysfunction	biomarker_for	phenotype	0.80
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
ALS	regulates	disease	0.65
SREBF1	contributes_to	gene	0.60
LDLR	contributes_to	gene	0.60
SREBF2	contributes_to	gene	0.60
FASN	regulates	gene	0.60
LDL	contributes_to	gene	0.60
Lipid Metabolism	contributes_to	pathway	0.60
T Cell	regulates	cell_type	0.60
AND	contributes_to	gene	0.60
VESICLE TRAFFICKING	regulates	gene	0.60
CANCER	regulates	gene	0.60
Raf	regulates	protein	0.60
App	regulates	protein	0.60
LDLR	implicated_in	gene	0.60
SREBF1	implicated_in	gene	0.60
SREBF2	implicated_in	gene	0.60
lipid metabolism	participates_in	pathway	0.60
ALDH2	activates	gene	0.60
CPT1A	activates	gene	0.60
FASN	activates	gene	0.60
IL1B	activates	gene	0.60
IL6	activates	gene	0.60
PPARA	activates	gene	0.60
SREBF1	activates	gene	0.60
T Cell	expressed_in	cell_type	0.55
benchmark_ot_ad_answer_key:ACACA	data_in	dataset_row	0.00

Incoming (9)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
Mi-891	downregulates	drug	0.85
GENES	contributes_to	gene	0.60
LDL	contributes_to	gene	0.60
SREBF1	contributes_to	gene	0.60
SREBF2	contributes_to	gene	0.60
LDLR	contributes_to	gene	0.60
FASN	regulates	gene	0.60
benchmark_ot_ad_answer_key:ACACA	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found