concept

VESICLE TRAFFICKING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VESICLE TRAFFICKING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

281Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

VESICLE TRAFFICKING is a concept in neurodegeneration research. Key relationships include: regulates, activates, interacts with. Associated with ALS, Aging, Als. Connected to 161 entities in the SciDEX knowledge graph.

View on Wiki →

💡 Concept Info

Name	VESICLE TRAFFICKING
Related Diseases	Neurodegeneration, Als, Ms, Amyotrophic Lateral Sclerosis, Dementia
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    VESICLE_TRAFFICKING["VESICLE TRAFFICKING"]
    VESICLE_TRAFFICKING -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    VESICLE_TRAFFICKING -->|"expressed in"| Ms["Ms"]
    VESICLE_TRAFFICKING -->|"expressed in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    VESICLE_TRAFFICKING -->|"expressed in"| Dementia["Dementia"]
    VESICLE_TRAFFICKING -->|"activates"| Cancer["Cancer"]
    VESICLE_TRAFFICKING -->|"activates"| Tumor["Tumor"]
    C9ORF72["C9ORF72"] -->|"regulates"| VESICLE_TRAFFICKING
    RAB5["RAB5"] -->|"activates"| VESICLE_TRAFFICKING
    OPTN["OPTN"] -->|"participates in"| VESICLE_TRAFFICKING
    SQSTM1["SQSTM1"] -->|"participates in"| VESICLE_TRAFFICKING
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| VESICLE_TRAFFICKING
    MOTOR_NEURONS["MOTOR NEURONS"] -->|"interacts"| VESICLE_TRAFFICKING
    ATG14["ATG14"] -->|"interacts"| VESICLE_TRAFFICKING
    UVRAG["UVRAG"] -->|"interacts"| VESICLE_TRAFFICKING
    MAP1LC3["MAP1LC3"] -->|"interacts"| VESICLE_TRAFFICKING

Outgoing (171)

Target	Relation	Type	Str
Neurodegeneration	regulates	disease	0.75
Als	associated_with	disease	0.75
Als	regulates	disease	0.75
Ms	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
ALS	regulates	disease	0.65
Frontotemporal Dementia	regulates	disease	0.65
Dementia	regulates	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Dementia	causes	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Parkinson	regulates	disease	0.65
Als	causes	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Insulin Resistance	activates	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Inflammation	contributes_to	disease	0.65
Ftd	causes	disease	0.65
Ms	causes	disease	0.65
Ms	contributes_to	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
ALS	activates	disease	0.65
Stroke	activates	disease	0.65
LYSOSOMAL BIOGENESIS	interacts_with	gene	0.60
C9ORF72 REPEAT EXPANSION	regulates	gene	0.60
CHMP2B	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60

Incoming (110)

Source	Relation	Type	Str
C9ORF72	regulates	gene	0.90
NEURODEGENERATION	regulates	gene	0.70
MOTOR NEURONS	interacts_with	gene	0.60
ATG14	interacts_with	gene	0.60
UVRAG	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
FASN	contributes_to	gene	0.60
RAB7A	interacts_with	gene	0.60
C9ORF72	transports	gene	0.60
MOTOR NEURONS	activates	gene	0.60
GAIN	activates	gene	0.60
CHMP2B	causes	gene	0.60
FIG4	causes	gene	0.60
C9ORF72 REPEAT EXPANSION	regulates	gene	0.60
ALS2	causes	gene	0.60
NEURON	interacts_with	gene	0.60
GAIN	causes	gene	0.60
RAB5	causes	gene	0.60
ENDOSOMES	interacts_with	gene	0.60
RAB7L1	regulates	gene	0.60
RAB5	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
ALS	associated_with	gene	0.60
FIG4	associated_with	gene	0.60
ALS2	associated_with	gene	0.60
GAIN	expressed_in	gene	0.60
LYSOSOMAL BIOGENESIS	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
SQSTM1	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
NEUROTOXICITY	regulates	gene	0.60
FERROPTOSIS	regulates	gene	0.60
ALS	causes	gene	0.60
SQSTM1	causes	gene	0.60
DEMENTIA	causes	gene	0.60
OPTN	causes	gene	0.60
CBL	activates	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
PI3K	activates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
BAX	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
AUTOPHAGY	contributes_to	gene	0.60
INFLAMMATION	contributes_to	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	0.60
AND	interacts_with	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
AND	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

VESICLE TRAFFICKING

Understanding Entity Pages

Summary

Wiki Pages (20)

Novel Therapy Index

Parkinson's Disease

Frontotemporal Dementia (FTD)

Synucleinopathy Mechanism