gene

SREBF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SREBF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

573Connections

2Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

15Debates

Summary

Page for SREBF2 — Sterol Regulatory Element Binding Transcription Factor 2

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🧬 Gene Info

Gene Symbol	SREBF2
Full Name	Sterol Regulatory Element Binding Transcription Factor 2
Chromosome	22
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	SREBF2 plays a critical role in cholesterol metabolism, which is intimately connected to Alzheimer's disease pathogenesis through multiple mechanisms:
Mechanism of Action	Small molecule modulators of transcriptional activity or protein-protein interactions
Druggability	Undruggable (0.20)
Clinical Stage	Phase II
Pathways	Amyloid, Autophagy, Cholesterol, Cholesterol Metabolism, Mitophagy
UniProt ID	A0AA34QVX2
Ensembl ID	ENSG00000198911
GeneCards	SREBF2
Human Protein Atlas	SREBF2
Associated Diseases	Als, Alzheimer, neurodegeneration
Known Drugs/Compounds	rapamycin, RAPAMYCIN
Interactions	ABCA1, ACOX1, Adiponectin, ADIPOQ, AGING, AKT3
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	APOE4-associated inflammatory signaling amplifies
KG Connections	573 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SREBF2 — AlphaFold A0AA34QVX2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SREBF2 — Sterol Regulatory Element Binding Transcription Factor 2

gene · 604 words

→

SREBF2 Protein — Sterol Regulatory Element Binding Factor 2 (SREBP-2)

protein · 670 words

→

Pathway Diagram

graph TD
    SREBF2["SREBF2"] -->|"associated"| neurodegeneration["neurodegeneration"]
    SREBF2["SREBF2"] -->|"interacts"| ABCA1["ABCA1"]
    SREBF2["SREBF2"] -->|"interacts"| LDLR["LDLR"]
    SREBF2["SREBF2"] -->|"interacts"| Tumor["Tumor"]
    SREBF2["SREBF2"] -->|"interacts"| Hepatitis["Hepatitis"]
    SREBF2["SREBF2"] -->|"regulates"| Alzheimer["Alzheimer"]
    h_9d29bfe5["h-9d29bfe5"] -->|"therapeutic target"| SREBF2["SREBF2"]
    ABCA1_1["ABCA1"] -->|"interacts"| SREBF2["SREBF2"]
    LDLR_2["LDLR"] -->|"interacts"| SREBF2["SREBF2"]
    PPARA["PPARA"] -->|"interacts"| SREBF2["SREBF2"]
    style SREBF2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (284)

Target	Relation	Type	Str
fatty acid synthesis	activates	process	0.90
triglyceride synthesis	activates	process	0.90
phospholipid synthesis	activates	process	0.90
cholesterol homeostasis	regulates	process	0.90
lipid homeostasis	regulates	process	0.90
cholesterol biosynthesis	activates	process	0.90
triglycerides	regulates	chemical	0.90
fatty acids	regulates	chemical	0.90
phospholipids	regulates	chemical	0.90
cholesterol	regulates	chemical	0.90
INSIG1	phosphorylates	gene	0.80
NLRP3 inflammasome	activates	entity	0.80
INSIG2	phosphorylates	gene	0.80
CYP51A1	upregulates	gene	0.80
cholesterol biosynthesis	upregulates	process	0.80
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
SQLE	activates	gene	0.70
HMGCR	activates	gene	0.70
lipid metabolism	participates_in	pathway	0.70
Parkinson's disease	risk_factor_for	disease	0.70
Alzheimer's disease	risk_factor_for	disease	0.70
LDLR	interacts_with	gene	0.68
neurodegeneration	associated_with	disease	0.68
ABCA1	interacts_with	gene	0.68
Cancer	regulates	disease	0.65
ALS	activates	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Dementia	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Aging	activates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
Tumor	interacts_with	disease	0.65
Frontotemporal Dementia	regulates	disease	0.65
Hepatitis	interacts_with	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	activates	disease	0.65
PRESENILIN	regulates	gene	0.60
Myelination	involved_in	pathway	0.60
AMPK	interacts_with	gene	0.60
RUBCNL	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
CREB	interacts_with	gene	0.60

Incoming (289)

Source	Relation	Type	Str
TDP-43	binds	protein	1.00
h-9d29bfe5	targets	hypothesis	0.90
LDLR	expressed_in	gene	0.70
OPTN	interacts_with	gene	0.70
ABCA1	interacts_with	gene	0.68
LDLR	interacts_with	gene	0.68
RAPAMYCIN	activates	drug	0.65
P53	activates	gene	0.65
MTOR	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
BECN1	co_discussed	gene	0.60
LAMP2	co_discussed	gene	0.60
MTOR	co_discussed	gene	0.60
SIRT1	co_discussed	gene	0.60
SQSTM1	co_discussed	gene	0.60
TAU	regulates	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
BECN1	associated_with	gene	0.60
SREBF1	contributes_to	gene	0.60
ABCA1	associated_with	gene	0.60
DHCR24	associated_with	gene	0.60
OPTN	protects_against	gene	0.60
PARKIN	promotes	gene	0.60
PINK1	promotes	gene	0.60
PINK1	co_discussed	gene	0.60
RUBCNL	activates	gene	0.60
rapamycin	targets	drug	0.60
ASTROCYTE	inhibits	cell_type	0.60
CYP46A1	expresses	gene	0.60
CYP46A1	inhibits	gene	0.60
CYP46A1	activates	gene	0.60
AD	expresses	gene	0.60
APP	expresses	gene	0.60
MITOPHAGY	protects_against	pathway	0.60
PINK1	enhances	gene	0.60
PSEN1	expresses	gene	0.60
LDLR	causes	gene	0.60
NFE2L2	regulates	gene	0.60
OPTN	co_discussed	gene	0.60
FASN	regulates	gene	0.60
PRKN	co_discussed	gene	0.60
AKT3	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
EGR1	interacts_with	gene	0.60
FGF14	interacts_with	gene	0.60
PLD3	interacts_with	gene	0.60
MITOPHAGY	regulates	gene	0.60
AMYLOID-BETA	regulates	gene	0.60
VESICLE TRAFFICKING	regulates	gene	0.60
ATG	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
APOE4-associated inflammatory signaling amplifies SREBP2 act	0.470	molecular-biology	Does APOE4's reduced lipid-binding direc
SREBF2 Direct Activator Hyper-Lipidation Strategy	0.380	molecular-biology	Is APOE4's reduced lipid binding pathoge