gene

SREBF2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SREBF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

557Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

Page for SREBF2 — Sterol Regulatory Element Binding Transcription Factor 2

View on Wiki →

🧬 Gene Info

Gene Symbol	SREBF2
Full Name	Sterol Regulatory Element Binding Transcription Factor 2
Chromosome	22
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	SREBF2 plays a critical role in cholesterol metabolism, which is intimately connected to Alzheimer's disease pathogenesis through multiple mechanisms:
Mechanism of Action	Small molecule modulators of transcriptional activity or protein-protein interactions
Druggability	Undruggable (0.20)
Clinical Stage	Phase II
Pathways	Amyloid, Autophagy, Cholesterol, Cholesterol Metabolism, Mitophagy
UniProt ID	A0AA34QVX2
Ensembl ID	ENSG00000198911
GeneCards	SREBF2
Human Protein Atlas	SREBF2
Associated Diseases	ALS, Alzheimer, neurodegeneration
Known Drugs/Compounds	RAPAMYCIN, rapamycin
Interactions	ABCA1, LDLR, NFE2L2, C1Q, HTRA2, MTOR
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	557 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SREBF2 — AlphaFold A0AA34QVX2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SREBF2["SREBF2"] -->|"associated"| neurodegeneration["neurodegeneration"]
    SREBF2["SREBF2"] -->|"interacts"| ABCA1["ABCA1"]
    SREBF2["SREBF2"] -->|"interacts"| LDLR["LDLR"]
    SREBF2["SREBF2"] -->|"interacts"| Tumor["Tumor"]
    SREBF2["SREBF2"] -->|"interacts"| Hepatitis["Hepatitis"]
    SREBF2["SREBF2"] -->|"regulates"| Alzheimer["Alzheimer"]
    h_9d29bfe5["h-9d29bfe5"] -->|"therapeutic target"| SREBF2["SREBF2"]
    ABCA1_1["ABCA1"] -->|"interacts"| SREBF2["SREBF2"]
    LDLR_2["LDLR"] -->|"interacts"| SREBF2["SREBF2"]
    PPARA["PPARA"] -->|"interacts"| SREBF2["SREBF2"]
    style SREBF2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (288)

Target	Relation	Type	Str
cholesterol	regulates	chemical	0.90
fatty acids	regulates	chemical	0.90
triglycerides	regulates	chemical	0.90
phospholipids	regulates	chemical	0.90
cholesterol biosynthesis	activates	biological_process	0.90
fatty acid synthesis	activates	biological_process	0.90
triglyceride synthesis	activates	biological_process	0.90
phospholipid synthesis	activates	biological_process	0.90
cholesterol homeostasis	regulates	biological_process	0.90
lipid homeostasis	regulates	biological_process	0.90
INSIG1	phosphorylates	gene	0.80
INSIG2	phosphorylates	gene	0.80
NLRP3 inflammasome	activates	entity	0.80
CYP51A1	upregulates	gene	0.80
cholesterol biosynthesis	upregulates	biological_process	0.80
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
lipid metabolism	participates_in	pathway	0.70
neurodegeneration	associated_with	disease	0.68
ABCA1	interacts_with	gene	0.68
LDLR	interacts_with	gene	0.68
Tumor	interacts_with	disease	0.65
Hepatitis	interacts_with	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	activates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Dementia	regulates	disease	0.65
ALS	activates	disease	0.65
ALS	regulates	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Frontotemporal Dementia	regulates	disease	0.65
NFE2L2	interacts_with	gene	0.60
C1Q	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
SIRT3	interacts_with	gene	0.60
PLIN2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60

Incoming (269)

Source	Relation	Type	Str
TDP-43	binds	protein	1.00
h-9d29bfe5	targets_gene	hypothesis	0.90
h-9d29bfe5	targets	hypothesis	0.80
ABCA1	interacts_with	gene	0.68
LDLR	interacts_with	gene	0.68
LDLR	expressed_in	gene	0.65
P53	activates	gene	0.65
RAPAMYCIN	activates	drug	0.65
PPARA	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
STX17	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NOS3	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
GLP1R	interacts_with	gene	0.60
SREBF1	interacts_with	gene	0.60
SIRT1	interacts_with	gene	0.60
KDM6B	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
PRKAA2	interacts_with	gene	0.60
LAMP2	interacts_with	gene	0.60
PLIN3	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
GRK2	interacts_with	gene	0.60
FOXO1	interacts_with	gene	0.60
NR1H3	interacts_with	gene	0.60
MAP3K5	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
HTRA2	interacts_with	gene	0.60
NFE2L2	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60
APP	activates	gene	0.60
OPTN	activates	gene	0.60
PINK1	regulates	gene	0.60
PARKIN	regulates	gene	0.60
HDAC6	activates	gene	0.60
BECN1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
BECN1	co_discussed	gene	0.60
LAMP2	co_discussed	gene	0.60
MTOR	co_discussed	gene	0.60
SIRT1	co_discussed	gene	0.60
SQSTM1	co_discussed	gene	0.60
PSEN1	activates	gene	0.60
FASN	regulates	gene	0.60
SREBF1	contributes_to	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

neurodegeneration | 2026-04-03 | 17 hypotheses Top: 0.662

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SREBF2

Understanding Entity Pages

Summary

Wiki Pages (21)

SREBF2 — Sterol Regulatory Element Binding Transcription Factor 2

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Therapeutics

coq10-neurodegeneration

Growth Factor Therapies

omega-3-fatty-acids-neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Coenzyme Q10 for Neurodegeneration

deferiprone-neurodegeneration

vitamin-d-therapy-neurodegeneration

Neuroprotection Strategies in Neurodegeneration

Curcumin for Neurodegeneration

Mediterranean and MIND Diets for Neurodegeneration

creatine-supplementation-neurodegeneration

Ambroxol for Neurodegeneration (GCase Chaperone Strategy)

rapamycin-tauopathy

NAD+ Precursors for Neurodegeneration

Exosome and Extracellular Vesicle Brain Delivery

tudca-udca-neurodegeneration

alpha-lipoic-acid-neurodegeneration

Exosome-Based Drug Delivery for CBS/PSP