cell 1,490 words KG: astrocytes 2026-03-24
kind:cell-typesection:cell-typesstate:published
Contents

Astrocytes in Amyotrophic Lateral Sclerosis

🧫 Cell Type Info
Cell Typeastrocytes
Definition<table class="infobox infobox-celltype">
Key MarkersCHI3L1, BMAL1, IL-6, Connexin43, YKL-40, AMYLOID-BETA, CONNEXIN43, ALKBH5
Key Pathwaysinsulin signaling, oxidative stress response, unfolded protein response, neurotrophin signaling, complement cascade
Associated DiseasesNREM Sleep, Parkinson's Disease, Postoperative Cognitive Dysfunction, Alzheimer Disease, Parkinson Disease, Huntington Disease
Linked Hypotheses157 hypotheses

Knowledge Graph

Related Hypotheses (30)

Multiplexed Base Editing for Simultaneous Neuroprotective Ge
Score: 0.53
Heterogeneous astrocyte activation states differentially imp
Score: 0.52
Acid-Degradable LNP-Mediated Prenatal CRISPR Intervention fo
Score: 0.47
Astrocyte-Mediated Microglial Memory Erasure
Score: 0.46
Adenosine-Astrocyte Metabolic Reset
Score: 0.56

Related Analyses (30)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archived
Microglial subtypes in neurodegeneration — friend vs foe
neuroscience · failed
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed

Related Experiments (21)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40
Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40
Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
ADNP Gene
gene · KG edge: inhibits
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: activates
ABCG4 Gene — ATP-Binding Cassette Subfamily G Member 4
gene · KG edge: regulates
ABCG1 Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

astrocytes associated_with neuroinflammation
astrocytes regulates α-synuclein
astrocytes regulates neuroinflammation
astrocytes produces GFAP
astrocytes regulates NRF2
astrocytes regulates CNS function
astrocytes expressed_in MMP9
astrocytes activates neuroinflammation
astrocytes activates proinflammatory cytokines
astrocytes activates mutant Huntingtin clearance