gene

CD38

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD38: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

581Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

CD38 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, Aging, Als. Connected to 290 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD38
Chromosome	4p15.32
Protein Type	Enzyme
Target Class	Enzyme
Function	cADPR acts as a potent second messenger that releases calcium from intracellular stores (endoplasmic reticulum) through ryanodine receptors[@guse2005].
Mechanism of Action	Monoclonal antibody targeting or small molecule inhibitor of NAD+ consuming activity
Primary Expression	various tissues including brain cells (neurons, astrocytes, microglia) and plays important roles in neuro
Druggability	Medium (0.61)
Clinical Stage	Approved
Amino Acids	301 aa
Pathways	Cerebrovascular, Circadian Rhythm, Differentiation, Immune Response, Mitochondrial Function
UniProt ID	H0Y950
Ensembl ID	ENSG00000104419
GeneCards	CD38
Human Protein Atlas	CD38
Associated Diseases	ALS, ALZHEIMER, Aging, Alzheimer's disease
Known Drugs/Compounds	NICOTINAMIDE, nicotinamide
Interactions	NAMPT, PARP1, EGR2, SIRT6, STAT3, SIRT1
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	572 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure: CD38 — PDB 1YH3 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CD38["CD38"] -->|"associated"| neurodegeneration["neurodegeneration"]
    CD38["CD38"] -->|"interacts"| NAMPT["NAMPT"]
    CD38["CD38"] -->|"co discussed"| C1Q["C1Q"]
    CD38["CD38"] -->|"co discussed"| NAMPT_1["NAMPT"]
    CD38["CD38"] -->|"co discussed"| GPX4["GPX4"]
    CD38["CD38"] -->|"co discussed"| PLA2G6["PLA2G6"]
    NAMPT_2["NAMPT"] -->|"interacts"| CD38["CD38"]
    MMP9["MMP9"] -->|"co discussed"| CD38["CD38"]
    SLC7A11["SLC7A11"] -->|"co discussed"| CD38["CD38"]
    AQP4["AQP4"] -->|"co discussed"| CD38["CD38"]
    style CD38 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (435)

Target	Relation	Type	Str
Lysosomal Cholesterol Efflux	promotes	process	0.95
Neurons	expressed_in	cell_type	0.90
Microglial Cells	expressed_in	cell_type	0.90
Lysosomal Cholesterol Efflux	associated_with	process	0.90
Astrocytes	expressed_in	cell_type	0.90
Nad	regulates	compound	0.85
Nad	catalyzes	compound	0.85
ADENOSINERGIC PATHWAY	involved_in	entity	0.85
purinergic signaling	regulates	pathway	0.85
mitochondrial transfer	mediates	process	0.85
mitochondrial transfer	associated_with	process	0.85
Mitochondrial Transfer	mediates	mechanism	0.85
Immune Response	involved_in	process	0.85
Neurodegeneration	involved_in	process	0.85
Neuroinflammation	involved_in	process	0.85
NAD metabolism	involved_in	pathway	0.80
NAMPT	co_mentioned_with	gene	0.80
programmed cell death	inhibits	process	0.80
Neurodegeneration	contributes_to	disease	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
APOPTOSIS	suppresses	process	0.80
NAD+ metabolism	regulates	pathway	0.80
ATP production	regulates	process	0.75
MIRO1	interacts_with	gene	0.75
Inflammation	associated_with	disease	0.75
Cancer	associated_with	disease	0.75
Aging	inhibits	disease	0.75
Inflammation	activates	disease	0.75
SIRT1	activates	gene	0.70
Parkinson's disease	protects_against	disease	0.70
Immune Response	regulates	pathway	0.70
unfolded protein response	participates_in	pathway	0.70
NAD	implicated_in	gene	0.70
macrophages	activates	cell_type	0.70
neural stem cells	expressed_in	cell_type	0.70
stem cells	expressed_in	cell_type	0.70
PARP1	reduces	gene	0.65
SIRT6	reduces	gene	0.65
Als	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Aging	regulates	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Longevity	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Als	activates	disease	0.65
Tumor	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65

Incoming (146)

Source	Relation	Type	Str
GJ-PD	upregulates	drug	0.90
h-cb833ed8	targets_gene	hypothesis	0.90
h-cb833ed8	targets	hypothesis	0.80
SDA-2026-04-01-gap-013	targets	analysis	0.80
GJ-PD herbal pair	upregulates	drug	0.80
Geum japonicum Thunb. var. chinense-Potentilla decorata H. Andres	upregulates	drug	0.80
Aging	upregulates	process	0.80
CANCER	associated_with	gene	0.70
NAD	inhibits	gene	0.70
NAD	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
NAMPT	interacts_with	gene	0.64
ADORA2B	associated_with	gene	0.60
P2RY12	associated_with	gene	0.60
P2RX1	associated_with	gene	0.60
P2RX4	associated_with	gene	0.60
P2RX7	associated_with	gene	0.60
NAMPT	inhibits	gene	0.60
SIRT6	inhibits	gene	0.60
EGR2	activates	gene	0.60
PARP1	inhibits	gene	0.60
P2RY1	associated_with	gene	0.60
PANX1	associated_with	gene	0.60
NAMPT	regulates	gene	0.60
SIRT1	regulates	gene	0.60
NAMPT	associated_with	gene	0.60
TFEB	activates	gene	0.60
LRRK2	regulates	gene	0.60
SIRT1	activates	gene	0.60
SLAMF7	therapeutic_target	gene	0.60
CCR1	regulates	gene	0.60
MRC1	regulates	gene	0.60
C1QB	regulates	gene	0.60
CXCL12	expressed_in	gene	0.60
SRC	expressed_in	gene	0.60
KIF5B	regulates	gene	0.60
RORA	associated_with	gene	0.60
BMP7	associated_with	gene	0.60
CX3CR1	associated_with	gene	0.60
AHR	associated_with	gene	0.60
EP300	associated_with	gene	0.60
JUN	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
CCL20	associated_with	gene	0.60
P2RX5	associated_with	gene	0.60
BAX	treats	gene	0.60
NLRP3	inhibits	gene	0.60
APOE	activates	gene	0.60
STAT3	activates	gene	0.60
CXCR4	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Mitochondrial transfer between astrocytes and neurons

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.570

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CD38

Understanding Entity Pages

Summary

Wiki Pages (21)

CD38 Molecule (CD38)

Novel Therapy Index

Neuroprotection Strategies in Neurodegeneration

uni-pittsburgh

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

NAD+ Precursors for Neurodegeneration

Cellular Senescence in Neurodegeneration

Section 103: Sirtuin Pathway and NAD+-Dependent Deacetylases in CBS/PSP

Nicotinamide Riboside

NAD+ Metabolism in Neurodegeneration

Neurons

Section 99: Purinergic Signaling and P2X/P2Y Receptors in CBS/PSP

Aging and Rejuvenation Knowledge Gaps

NNMT Gene

Sirtuin Modulators for Parkinson's Disease

SIRT1 Signaling Pathway in Alzheimer's Disease

NMNAT1 Gene

FC Gamma Receptor IIIA

SARM1 NADase Inhibition for Axonal Preservation

Mitochondrial NAD Redox Swing Protocol with Temporal Dosing Windows

NAD Signaling in Neurodegeneration