| Gene Symbol | CDKN1A |
| Full Name | Cyclin-Dependent Kinase Inhibitor 1A |
| Chromosome | 6p21.31 |
| Function | is a key cell cycle regulator that mediates p53-dependent cell cycle arrest. |
| Amino Acids | 164 aa |
| Pathways | TGF-β |
| UniProt ID | P38936 |
| NCBI Gene ID | 1026 |
| Ensembl ID | ENSG00000100994 |
| GeneCards | CDKN1A |
| Human Protein Atlas | CDKN1A |
| N-terminal domain | binds and inhibits CDK2/cyclin E and CDK1/cyclin B complexes |
| C-terminal domain | interacts with PCNA (proliferating cell nuclear antigen), blocking DNA replication |
| p53-binding region | contains p53-responsive elements for transcriptional activation |
| Neurons | particularly in post-mitotic differentiated neurons |
| Associated Diseases | Aging, Als, Alzheimer, Cancer, Cellular Senescence |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACTB, AGING, AGO2, AKT, AND, APOPTOSIS |
| SciDEX Hypotheses | p21-Targeted Proteolysis-Targeting Chimeras (PROTA |
| KG Connections | 470 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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