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gene 1,625 words KG: CDKN2A
Contents

CDKN2A Gene

🧬 Gene Info
Gene SymbolCDKN2A
Chromosome9p21.3
Functionis a 156-amino acid protein composed of ankyrin repeat domains that adopt a highly twisted, left-handed helix structure[@li2019].
Molecular Weight16 kDa
Amino Acids156 aa
PathwaysGlycolysis, Tgf-Β
UniProt IDP42771
NCBI Gene ID1029
Ensembl IDENSG00000147883
GeneCardsCDKN2A
Human Protein AtlasCDKN2A
p12^INK4a^Alternatively spliced variant with truncated N-terminus
Associated DiseasesAging, Als, Alzheimer, Atherosclerosis, Cancer, Carcinoma
Known Drugs/Compoundsrapamycin
InteractionsAGING, AKT, AKT3, AND, APC, APOPTOSIS
SciDEX HypothesesSenescence-Tau Decoupling Therapy
Hippocampal-Cortical Transcriptomic Divergence Rev
KG Connections458 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (20)

p16^INK4a-CCF Axis as Senolytic Timing Biomarker
Score: 0.81Pericyte-targeted senolysis or senomorphic therapy will bene
Score: 0.70Dasatinib plus Quercetin Senolytic Clearance of p16Ink4a-Hig
Score: 0.68Metabolic Checkpoint Failure in NG2+ Oligodendrocyte Progeni
Score: 0.68OPC exhaustion and failed remyelination in progressive multi
Score: 0.67Pericyte senescence is sufficient to weaken the BBB even wit
Score: 0.63Epigenetic Bivalency at CDKN2A Locus Distinguishes Senescent
Score: 0.63H1: Senolytic Clearance of Senescent APOE4 Astrocytes
Score: 0.61Senescence-Tau Decoupling Therapy
Score: 0.59H7: Dual-Target Strategy (Senolytics + APOE4→3 Conversion)
Score: 0.58Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc
Score: 0.56CyclinD1-Tagged Partial Cellular Reprogramming via Modified
Score: 0.53Telomere Attrition and DNA Damage Response Activation Induce
Score: 0.52Hippocampal-Cortical Transcriptomic Divergence Reveals Accel
Score: 0.52Astrocyte senescence and SASP-driven neuroinflammation in AL
Score: 0.51miR-33 Antisense-Enhanced APOE4 Lipidation as Senolytic Timi
Score: 0.38Senescent Cell-Derived SPM Antagonist Neutralization
Score: 0.00Selective Microglial Senescence Targeting via P16INK4A-Guide
Score: 0.00Senescence-Induced Tau Propagation Blockade
Score: 0.00Circadian-Timed Senolytic Therapy
Score: 0.00

Knowledge Graph (12 edges)

CDKN2A inhibits cell cycle progression
FGFR1 therapeutic_target CDKN2A
SOX2 therapeutic_target CDKN2A
CDK4 inhibits CDKN2A
RB1 inhibits CDKN2A
CDKN2A therapeutic_target EZH2
CDKN2A therapeutic_target NSD3
PTEN associated_with CDKN2A
EGR4 associated_with CDKN2A
EGFR associated_with CDKN2A

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