| Gene Symbol | HDAC6 |
| Full Name | Histone Deacetylase 6 |
| Chromosome | Xp11.23 |
| Protein Type | Protein |
| Function | is a unique class IIb histone deacetylase that predominantly localizes to the cytoplasm rather than the nucleus. |
| Primary Expression | Ubiquitous, highest in brain, liver, kidney |
| Subcellular Localization | the cytoplasm. Unlike other HDACs, HDAC6 predominantly t |
| Molecular Weight | 131 kDa |
| Amino Acids | 1215 aa |
| Pathways | AUTOPHAGY, Amyloid, Autophagy, Dna Repair, Inflammasome |
| UniProt ID | Q9UQR8 |
| NCBI Gene ID | 10013 |
| Ensembl ID | ENSG00000094631 |
| GeneCards | HDAC6 |
| Human Protein Atlas | HDAC6 |
| Associated Diseases | Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Cancer, Cardiovascular, Diabetes |
| Known Drugs/Compounds | curcumin, lithium, Ramalin, rapamycin |
| Interactions | ACAT1, ACTB, Actin, ADCY3, AGING, AGO2 |
| SciDEX Hypotheses | HDAC6 Inhibition for Charcot-Marie-Tooth Disease a HDAC6 Selective Inhibition to Restore Acetylation HDAC6 Inhibition for Dual Restoration of Microtubu (+1 more) |
| KG Connections | 1123 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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